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1.发明授权11-beta, 17-alpha, 21-trihydroxy-1, 4-pregnadiene-3, 20 21-[(E-E)-3,7, 11-trimethyl-2,6,10-dodecatrienoate] 失效11-β，17-α，21-三羟基-1,4-孕二烯-3,201 - [（E-E）-3,7,11-三甲基-2,6,10-十二碳三烯酸酯]
公开(公告)号：US5278156A
公开(公告)日：1994-01-11
申请号：US856858
申请日：1992-03-24
申请人： Yutaka Mizushima , Keiko Hoshi , Rie Igarashi , Hirofusa Ajioka , Noriyuki Yamamoto , Masahito Komuro , Koichi Kanehira , Masayuki Inoue , Takashi Nishida , Michio Terasawa , Kenzo Arizono
发明人： Yutaka Mizushima , Keiko Hoshi , Rie Igarashi , Hirofusa Ajioka , Noriyuki Yamamoto , Masahito Komuro , Koichi Kanehira , Masayuki Inoue , Takashi Nishida , Michio Terasawa , Kenzo Arizono
CPC分类号： C07J5/0053
摘要： 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.
摘要翻译： 11β，17α，21-三羟基-1,4-孕二烯-3,20-二酮21 - [（E，E）-3,7,11-三甲基-2,6,10-十二碳三烯酸酯] IMAGE>其抗炎组合物及其制备方法。 11β，17α，21-三羟基-1,4-孕二烯-3,20-二酮21 - [（E，E）-3,7,11-三甲基-2,6,10-十二碳三烯酸酯] 显示出显着优异的抗炎作用，此外，显示出副作用降低，并且可以以高选择性和良好的产率和方便地制备。
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2.发明授权11.beta., 17.alpha.,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] 失效11β，17α，21-三羟基-1,4-孕二烯-3,20-二酮21 - [（E，E）-3,7,11-三甲基-2,6,10-十二碳三烯酸酯]
公开(公告)号：US5015746A
公开(公告)日：1991-05-14
申请号：US299681
申请日：1989-01-23
申请人： Yutaka Mizushima , Keiko Hoshi , Rie Igarashi , Hirofusa Ajioka , Noriyuki Yamamoto , Masahito Komuro , Koichi Kanehira , Masayuki Inoue , Takashi Nishida , Manzo Shiono , Michio Terasawa , Kenzo Arizono
发明人： Yutaka Mizushima , Keiko Hoshi , Rie Igarashi , Hirofusa Ajioka , Noriyuki Yamamoto , Masahito Komuro , Koichi Kanehira , Masayuki Inoue , Takashi Nishida , Manzo Shiono , Michio Terasawa , Kenzo Arizono
IPC分类号： C07J5/00
CPC分类号： C07J5/0053
摘要： 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.
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