公开(公告)号：US5015746A

公开(公告)日：1991-05-14

申请号：US299681

申请日：1989-01-23

申请人： Yutaka Mizushima ,  Keiko Hoshi ,  Rie Igarashi ,  Hirofusa Ajioka ,  Noriyuki Yamamoto ,  Masahito Komuro ,  Koichi Kanehira ,  Masayuki Inoue ,  Takashi Nishida ,  Manzo Shiono ,  Michio Terasawa ,  Kenzo Arizono

发明人： Yutaka Mizushima ,  Keiko Hoshi ,  Rie Igarashi ,  Hirofusa Ajioka ,  Noriyuki Yamamoto ,  Masahito Komuro ,  Koichi Kanehira ,  Masayuki Inoue ,  Takashi Nishida ,  Manzo Shiono ,  Michio Terasawa ,  Kenzo Arizono

IPC分类号： C07J5/00

CPC分类号： C07J5/0053

摘要： 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.

公开(公告)号：US5278156A

公开(公告)日：1994-01-11

申请号：US856858

申请日：1992-03-24

申请人： Yutaka Mizushima ,  Keiko Hoshi ,  Rie Igarashi ,  Hirofusa Ajioka ,  Noriyuki Yamamoto ,  Masahito Komuro ,  Koichi Kanehira ,  Masayuki Inoue ,  Takashi Nishida ,  Michio Terasawa ,  Kenzo Arizono

发明人： Yutaka Mizushima ,  Keiko Hoshi ,  Rie Igarashi ,  Hirofusa Ajioka ,  Noriyuki Yamamoto ,  Masahito Komuro ,  Koichi Kanehira ,  Masayuki Inoue ,  Takashi Nishida ,  Michio Terasawa ,  Kenzo Arizono

IPC分类号： C07J5/00 ,  A61K31/56

CPC分类号： C07J5/0053

摘要： 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.

摘要翻译： 11β，17α，21-三羟基-1,4-孕二烯-3,20-二酮21 - [（E，E）-3,7,11-三甲基-2,6,10-十二碳三烯酸酯] IMAGE>其抗炎组合物及其制备方法。 11β，17α，21-三羟基-1,4-孕二烯-3,20-二酮21 - [（E，E）-3,7,11-三甲基-2,6,10-十二碳三烯酸酯] 显示出显着优异的抗炎作用，此外，显示出副作用降低，并且可以以高选择性和良好的产率和方便地制备。

公开(公告)号：US4525348A

公开(公告)日：1985-06-25

申请号：US562570

申请日：1983-12-19

申请人： Kenzo Arizono ,  Michio Terasawa ,  Michiharu Nobutoki

发明人： Kenzo Arizono ,  Michio Terasawa ,  Michiharu Nobutoki

IPC分类号： A61K31/44 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K31/78

CPC分类号： A61K47/36 ,  A61K31/44 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  A61K9/0014

摘要： An antiinflammatory and analgesic gelled ointment contains pranoprofen, at least one member selected from the group consisting of lower aliphatic alcohol, polyethylene glycol, methyl ethyl ketone and acetone, a gelling agent selected from the group consisting of carboxyvinyl polymer, hydroxyethyl cellulose, alginic acid and carboxymethyl cellulose, a water-soluble basic substance selected from the group consisting of ammonia, sodium hydroxide, potassium hydroxide, triethanolamine, diethanolamine, diisopropanolamine, triisopropanolamine and triethylamine, and water.

摘要翻译： 抗炎止痛凝胶软膏含有双吡喃丙酸，选自低级脂肪醇，聚乙二醇，甲基乙基酮和丙酮中的至少一种，选自羧乙烯基聚合物，羟乙基纤维素，海藻酸和 羧甲基纤维素，选自氨，氢氧化钠，氢氧化钾，三乙醇胺，二乙醇胺，二异丙醇胺，三异丙醇胺和三乙胺的水溶性碱性物质和水。