公开(公告)号：US5053407A

公开(公告)日：1991-10-01

申请号：US876623

申请日：1986-06-20

申请人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

发明人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

IPC分类号： A61K31/50 ,  C07B57/00 ,  C07D265/36 ,  C07D413/06 ,  C07D498/06

CPC分类号： C07D413/06 ,  C07D265/36

摘要： An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.

公开(公告)号：US4985557A

公开(公告)日：1991-01-15

申请号：US327653

申请日：1989-03-23

申请人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

发明人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

IPC分类号： A61K31/50 ,  C07B57/00 ,  C07D265/36 ,  C07D413/06 ,  C07D498/06

CPC分类号： C07D413/06 ,  C07D265/36

摘要： An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.

摘要翻译： 公开了光学活性吡啶并苯并恶嗪衍生物，其制备方法和可用于制备光学活性吡啶并苯并恶嗪衍生物的新型中间体。 光学活性的吡啶并苯并恶嗪衍生物具有增加的抗微生物活性和降低的毒性。 中间体可用于制备诸如氧氟沙星和anolog化合物之类的光学活性吡啶并苯并恶嗪衍生物。

公开(公告)号：US5142046A

公开(公告)日：1992-08-25

申请号：US754198

申请日：1991-08-28

申请人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

发明人： Isao Hayakawa ,  Shohgo Atarashi ,  Masazumi Imamura ,  Shuichi Yokohama ,  Nobuyuki Higashihashi ,  Katsuichi Sakano ,  Masayuki Ohshima

IPC分类号： A61K31/50 ,  C07B57/00 ,  C07D265/36 ,  C07D413/06 ,  C07D498/06

CPC分类号： C07D413/06 ,  C07D265/36

摘要： An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.

摘要翻译： 公开了光学活性吡啶并苯并恶嗪衍生物，其制备方法和可用于制备光学活性吡啶并苯并恶嗪衍生物的新型中间体。 光学活性的吡啶并苯并恶嗪衍生物具有增加的抗微生物活性和降低的毒性。 中间体可用于制备诸如氧氟沙星和anolog化合物之类的光学活性吡啶并苯并恶嗪衍生物。