公开(公告)号：US06828323B2

公开(公告)日：2004-12-07

申请号：US09777727

申请日：2001-02-05

申请人： Matthew Stewart Platz ,  Raymond Paul Goodrich, Jr.

发明人： Matthew Stewart Platz ,  Raymond Paul Goodrich, Jr.

IPC分类号： A01N102

CPC分类号： A61L2/0076 ,  A61L2/0088 ,  A61L2/10 ,  A61L2202/22 ,  C07D475/14

摘要： Methods are provided for neutralization of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an activation-effective amount of a microorganism neutralizer with an isoalloxazine backbone to a fluid and exposing the fluid to a triggering event. Preferred triggering events include light of a suitable wavelength and intensity to activate the microorganism neutralizer or a pH sufficient to activate the microorganism neutralizer. Other fluids, including juices, water and the like, may also be decontaminated by these methods as may surfaces of foods, animal carcasses, wounds, food preparation surfaces and bathing and washing vessel surfaces. Compounds with an isoalloxazine backbone are also provided.

摘要翻译： 提供了用于中和流体或表面上的微生物的方法。 优选地，流体含有血液或血液制品并且包含生物活性蛋白质。 优选的方法包括以下步骤：将活化有效量的微生物中和剂与异吲嗪骨架加入流体中，并将​​流体暴露于触发事件。 优选的触发事件包括合适的波长和强度的光以激活微生物中和剂或足以活化微生物中和剂的pH。 其他流体，包括果汁，水等也可以通过这些方法，如食品，动物屠体，伤口，食物制备表面和洗浴和洗涤容器表面的表面进行去污染。 还提供了具有异吲哚啉主链的化合物。

公开(公告)号：US06268120B1

公开(公告)日：2001-07-31

申请号：US09420652

申请日：1999-10-19

申请人： Matthew Stewart Platz ,  Raymond Paul Goodrich, Jr.

发明人： Matthew Stewart Platz ,  Raymond Paul Goodrich, Jr.

IPC分类号： A01N102

CPC分类号： A61L2/0076 ,  A61L2/0088 ,  A61L2/10 ,  A61L2202/22 ,  C07D475/14

摘要： Methods are provided for neutralization of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an activation-effective amount of a microorganism neutralizer with an isoalloxazine backbone to a fluid and exposing the fluid to a triggering event. Preferred triggering events include light of a suitable wavelength and intensity to activate the microorganism neutralizer or a pH sufficient to activate the microorganism neutralizer. Other fluids, including juices, water and the like, may also be decontaminated by these methods as may surfaces of foods, animal carcasses, wounds, food preparation surfaces and bathing and washing vessel surfaces. Compounds with an isoalloxazine backbone are also provided.

摘要翻译： 提供了用于中和流体或表面上的微生物的方法。 优选地，流体含有血液或血液制品并且包含生物活性蛋白质。 优选的方法包括以下步骤：将活化有效量的微生物中和剂与异吲嗪骨架加入流体中，并将​​流体暴露于触发事件。 优选的触发事件包括合适的波长和强度的光以激活微生物中和剂或足以活化微生物中和剂的pH。 其他流体，包括果汁，水等也可以通过这些方法，如食品，动物屠体，伤口，食物制备表面和洗浴和洗涤容器表面的表面进行去污染。 还提供了具有异吲哚啉主链的化合物。