公开(公告)号：US20180353629A9

公开(公告)日：2018-12-13

申请号：US15645480

申请日：2017-07-10

申请人： S. Edward Neister ,  John James Rowsey

发明人： S. Edward Neister ,  John James Rowsey

IPC分类号： A61L2/00 ,  A61N5/06

CPC分类号： A61L2/0047 ,  A23B7/015 ,  A23L3/26 ,  A23L3/28 ,  A61L2/0011 ,  A61L2/10 ,  A61L9/20 ,  A61L2202/22 ,  A61N5/0624 ,  A61N2005/063 ,  A61N2005/0654 ,  A61N2005/0661 ,  B08B17/00

摘要： This invention relates to a method, process and apparatus for disinfecting and sterilizing all types of surfaces contaminated with microorganisms and toxic substances to render both inactive. Furthermore, this invention relates to both a method and apparatus for disinfecting and/or sterilizing breathable air and then using this air to protect a confined space from external contamination. The apparatus consists of a new ultra-violet (NUV) source that is more effective than mercury based 254 nm light for destroying DNA of virus, bacteria, spores and cists. It is most effective in breaking chemical bonds in toxic gases and Biotoxins that are useful to terrorists. It is combined with other apparatus that remove particulates and byproducts sometimes produced by the NUV source and maintains positive pressure of the confined space so as to prevent the influx of air from outside the protected zone.

公开(公告)号：US09987409B2

公开(公告)日：2018-06-05

申请号：US14722756

申请日：2015-05-27

申请人： Nipro Corporation

发明人： Kimihiro Mabuchi ,  Noriko Monden ,  Noriaki Kato ,  Yuuki Hatakeyama ,  Takashi Sunohara ,  Toshiaki Masuda

IPC分类号： B01D39/00 ,  B01D39/14 ,  A61M1/16 ,  A61L2/08 ,  B01D65/02 ,  B01D67/00 ,  B01D71/68 ,  B01D69/08

CPC分类号： A61M1/168 ,  A61L2/087 ,  A61L2202/22 ,  A61M1/16 ,  A61M1/1682 ,  A61M1/169 ,  A61M2209/06 ,  B01D65/022 ,  B01D67/0011 ,  B01D67/0097 ,  B01D69/08 ,  B01D71/68 ,  B01D2321/34 ,  B01D2323/34 ,  B01D2325/36 ,  B01D2325/38

摘要： The invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The blood purifier comprises selectively permeable separation membranes as a main component and is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.

公开(公告)号：US20170100494A1

公开(公告)日：2017-04-13

申请号：US15292236

申请日：2016-10-13

申请人： Sensor Electronic Technology, Inc.

发明人： Alexander Dobrinsky ,  Timothy James Bettles ,  Michael Shur

IPC分类号： A61L2/10 ,  A61L2/24

CPC分类号： A61L2/10 ,  A23C3/076 ,  A61L2/0047 ,  A61L2/088 ,  A61L2/24 ,  A61L2202/14 ,  A61L2202/21 ,  A61L2202/22 ,  A61L2202/24

摘要： A system for providing ultraviolet treatment to light absorbing liquids, such as biological liquids in a medical instrument, is disclosed. The system can include an ultraviolet impenetrable housing configured to enclose a portion of the medical instrument containing the biological fluid. At least one ultraviolet radiation source is integrated within the housing that emits ultraviolet radiation towards the medical instrument and the biological fluid. A control unit is configured to direct the ultraviolet radiation source to treat the biological fluid with ultraviolet radiation.

公开(公告)号：US09526913B2

公开(公告)日：2016-12-27

申请号：US14168795

申请日：2014-01-30

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC分类号： A61N5/06 ,  A61K49/00 ,  A61L2/08 ,  A61N1/40 ,  A61N5/02

CPC分类号： A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

摘要： A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light, and a metallic structure attached to the phosphorescent material. The metallic structure has a surface plasmon resonance which resonates at a frequency which spectrally overlaps with one or more frequencies of the emitted light.

摘要翻译： 一种用于增强介质内发射光的基于纳米颗粒的系统。 基于纳米颗粒的系统包括磷光材料，其在激活时产生发射的光，以及附着到磷光材料的金属结构。 金属结构具有表面等离子体共振，其以与所发射的光的一个或多个频率光谱重叠的频率谐振。

公开(公告)号：US20160367742A1

公开(公告)日：2016-12-22

申请号：US15122143

申请日：2015-02-27

申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

发明人： Jürgen HÄCKER

IPC分类号： A61M1/16 ,  A61L2/00 ,  A61L2/24

CPC分类号： A61M1/168 ,  A61L2/0017 ,  A61L2/24 ,  A61L2202/14 ,  A61L2202/22 ,  A61M1/14 ,  A61M1/1686 ,  A61M1/3621 ,  A61M2205/12 ,  A61M2205/121 ,  A61M2205/128

摘要： A blood treatment cassette having a cassette body embodied as a hard part and, optionally, a film which is connected to the hard part and at least partially covers the hard part, wherein the hard part comprises at least one sterilization opening, and wherein the sterilization opening comprises a closure device. The invention also relates to a blood treatment apparatus for using the blood treatment cassette.

摘要翻译： 一种血液处理盒，其具有体现为硬部件的盒体，以及可选地连接到硬部件并且至少部分地覆盖硬部件的膜，其中所述硬部件包括至少一个灭菌开口，并且其中所述灭菌 开口包括闭合装置。 本发明还涉及一种使用血液处理盒的血液处理装置。

公开(公告)号：US20160242410A9

公开(公告)日：2016-08-25

申请号：US13289722

申请日：2011-11-04

申请人： TATSURO YOSHIDA ,  Paul Vernucci

发明人： TATSURO YOSHIDA ,  Paul Vernucci

IPC分类号： A01N1/02

CPC分类号： A01N1/0242 ,  A01N1/0205 ,  A01N1/0263 ,  A01N1/0278 ,  A01N1/0294 ,  A61J1/10 ,  A61L2/081 ,  A61L2/082 ,  A61L2202/181 ,  A61L2202/22

摘要： A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon dioxide depletion device to the storage vessel; and a gamma or X-ray irradiating device is used to irradiate red blood cells stored in the vessel, storing red blood cells under anaerobic conditions.

摘要翻译： 一种血液储存系统，包括：用于红细胞的收集容器; 氧气或氧气和二氧化碳消耗装置; 用于红细胞的储存容器; 将收集容器连接到氧气或氧气和二氧化碳消耗装置以及将氧气或氧气和二氧化碳消耗装置连接到储存容器的管道; 并且使用γ或X射线照射装置照射存储在血管中的红细胞，在厌氧条件下储存红细胞。

公开(公告)号：US09421288B2

公开(公告)日：2016-08-23

申请号：US13789848

申请日：2013-03-08

申请人： Thomas J. Lowe

发明人： Thomas J. Lowe

IPC分类号： A61L2/10 ,  A61L2/08 ,  C02F1/32 ,  F15D1/00 ,  F15D1/02 ,  B01F5/00

CPC分类号： A61L2/10 ,  A61L2/084 ,  A61L2202/22 ,  C02F1/325 ,  C02F2201/3222 ,  C02F2201/3227 ,  C02F2201/328 ,  C02F2301/024 ,  C02F2301/026 ,  F15D1/0005 ,  Y10T137/0318

摘要： Blood or other fluid can be treated with UV or other light, such as using an apparatus that can include a cuvette. The cuvette can include an elongated tube configured to permit passage of light of a desired wavelength into the tube, which can include a fluid inlet at a first end and a fluid outlet at a longitudinally opposing second end. A turbulator within the tube can include a helical baffle segment configured to induce mixing and rotation of fluid flow about a longitudinal axis of the tube. The method can include passing a fluid, from a fluid inlet at a first end of an elongated tube to a fluid outlet at a longitudinally opposing second end of the elongated tube. Mixing and rotational flow of the fluid can be induced within the tube about a longitudinal axis of the tube and light of a desired wavelength can be permitted into the tube.

摘要翻译： 血液或其他液体可以用UV或其他光来处理，例如使用可以包括比色杯的装置。 试管可以包括细长管，其配置成允许将期望波长的光通过到管中，该管可包括在第一端处的流体入口和在纵向相对的第二端处的流体出口。 管内的湍流器可以包括螺旋挡板段，其构造成引起围绕管的纵向轴线的流体流动的混合和旋转。 该方法可以包括将流体从细长管的第一端处的流体入口传递到细长管的纵向相对的第二端处的流体出口。 流体的混合和旋转流可以在管内围绕管的纵向轴线诱发，并且可以允许所需波长的光进入管中。

公开(公告)号：US20160195555A1

公开(公告)日：2016-07-07

申请号：US14976950

申请日：2015-12-21

申请人： Fenwal, Inc.

发明人： Christopher J. Wegener ,  Katherine N. Radwanski

IPC分类号： G01N33/80 ,  G01N21/33

CPC分类号： G01N33/80 ,  A61L2/10 ,  A61L2202/22 ,  A61M1/0209 ,  A61M1/3683 ,  A61M1/3693 ,  A61M2205/051 ,  A61M2205/053 ,  A61M2230/207 ,  G01N21/33 ,  G01N2201/061 ,  G01N2201/12

摘要： An irradiation device for photopheresis, comprising an exposure chamber configured to receive an illumination container holding a target cell suspension, an irradiation transmitter configured to irradiate the illumination container and target cell suspension, an irradiation receiver configured to detect absorption of radiation from the irradiation transmitter, and a processing circuit coupled to the irradiation receiver and configured to determine whether a hematocrit of the target cell suspension exceeds a predetermined threshold hematocrit and to treat the target cell suspension with a treatment dosage of radiation if the predetermined threshold is exceeded.

摘要翻译： 一种用于光照射的照射装置，包括：曝光室，被配置为容纳保持靶细胞悬浮液的照明容器;被配置为照射所述照明容器和靶细胞悬浮液的照射发射器;被配置为检测来自所述照射发射器的辐射的吸收的照射接收器， 以及处理电路，其耦合到所述照射接收器并且被配置为确定所述靶细胞悬浮液的血细胞比容是否超过预定阈值血细胞比容，并且如果超过所述预定阈值，则以所述辐射治疗剂量治疗所述靶细胞悬浮液。

公开(公告)号：US09278331B2

公开(公告)日：2016-03-08

申请号：US14635677

申请日：2015-03-02

申请人： IMMUNOLIGHT, LLC.

发明人： Frederic A. Bourke, Jr.

IPC分类号： B01J19/12

CPC分类号： A61N5/10 ,  A23L2/50 ,  A23L3/26 ,  A23L3/263 ,  A23L3/28 ,  A23L5/32 ,  A23V2002/00 ,  A61K41/0057 ,  A61K41/0066 ,  A61L2/0011 ,  A61L2/0047 ,  A61L2/0076 ,  A61L2/082 ,  A61L2/088 ,  A61L2/10 ,  A61L2/16 ,  A61L2202/21 ,  A61L2202/22 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/1098 ,  B01J19/082 ,  B01J19/085 ,  B01J19/12 ,  B01J19/123 ,  B01J19/125 ,  B01J19/127 ,  B01J19/128 ,  B01J23/50 ,  B01J23/52 ,  B01J31/0275 ,  B01J31/2295 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/004 ,  B01J37/0072 ,  B01J37/0221 ,  B01J2219/0877 ,  B01J2219/0879 ,  B01J2219/0892 ,  B01J2219/1203 ,  B01J2231/005 ,  B01J2531/005 ,  B01J2531/008 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C02F1/30 ,  C02F1/302 ,  C02F1/305 ,  C02F1/307 ,  C02F1/32 ,  C02F1/725 ,  C02F2305/10 ,  C08J3/24 ,  C08J3/28 ,  C08J7/18 ,  C08J2300/00 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  C09J2205/31 ,  C12H1/06 ,  G02B5/008 ,  G21K5/00 ,  Y02W10/37 ,  Y10S977/774 ,  Y10S977/777 ,  Y10S977/896 ,  Y10S977/915 ,  Y10T156/10

摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US09259525B2

公开(公告)日：2016-02-16

申请号：US12563958

申请日：2009-09-21

申请人： Derek J. Hei

发明人： Derek J. Hei

IPC分类号： A61M1/36 ,  A61M1/02 ,  A01N1/02 ,  A61L2/00 ,  B01J20/26 ,  B01J20/28 ,  C12N11/08 ,  C07D493/04 ,  C07D219/10 ,  C07D405/12 ,  C07F9/64 ,  B01J20/20

CPC分类号： A61M1/3679 ,  A01N1/0215 ,  A01N1/0231 ,  A61K35/18 ,  A61L2/00 ,  A61L2/0082 ,  A61L2202/22 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/3686 ,  B01J20/20 ,  B01J20/26 ,  B01J20/261 ,  B01J20/28004 ,  B01J20/28014 ,  B01J20/28019 ,  B01J20/28026 ,  B01J20/28028 ,  B01J20/28057 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  C07D219/10 ,  C07D405/12 ,  C07D493/04 ,  C07F9/64 ,  C12N11/08

摘要： Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 100 μm to about 1500 μm. The device can be used to adsorb and remove a pathogen-inactivating compounds from a biological composition such as a blood product.

摘要翻译： 提供的方法和装置用于降低含有细胞的生物组合物中的低分子量化合物的浓度，同时基本保持生物组合物的所需生物活性。 该装置包括高度多孔的吸附剂颗粒，吸附剂颗粒通过惰性基质固定。 含有颗粒的基质包含在壳体中，并且颗粒的直径范围为约100μm至约1500μm。 该装置可用于从诸如血液制品的生物组合物中吸附和去除病原体灭活化合物。