公开(公告)号：US12089589B2

公开(公告)日：2024-09-17

申请号：US17702586

申请日：2022-03-23

申请人： Hemanext Inc.

发明人： Tatsuro Yoshida ,  Paul Vernucci

IPC分类号： A01N1/02 ,  A61K35/18 ,  A61J1/10 ,  A61L2/08

CPC分类号： A01N1/0242 ,  A01N1/0205 ,  A01N1/0263 ,  A01N1/0278 ,  A01N1/0294 ,  A61K35/18 ,  A61J1/10 ,  A61L2/081 ,  A61L2/082 ,  A61L2202/181 ,  A61L2202/22

摘要： A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon dioxide depletion device to the storage vessel; and a gamma or X-ray irradiating device is used to irradiate red blood cells stored in the vessel, storing red blood cells under anaerobic conditions.

公开(公告)号：US20240148872A1

公开(公告)日：2024-05-09

申请号：US18417268

申请日：2024-01-19

申请人： Hemanext Inc.

发明人： Samuel O. SOWEMIMO-COKER ,  Jeffrey SUTTON ,  Tatsuro YOSHIDA

IPC分类号： A61K41/17 ,  A61K35/18 ,  A61L2/00

CPC分类号： A61K41/17 ,  A61K35/18 ,  A61L2/0047 ,  A61L2/0076 ,  A61L2/0082 ,  A61L2202/22

摘要： A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.

公开(公告)号：US20240131062A1

公开(公告)日：2024-04-25

申请号：US18467063

申请日：2023-09-14

申请人： Velico Medical, Inc.

发明人： Mark A. Popovsky ,  Lisa A. Buckley ,  Jihae Sohn ,  Evan P. Ordway ,  Qiyong Peter Liu ,  Robert R. Andrews ,  Herman E. Snyder ,  William J. Merritt ,  Clair Strohl ,  Russell J Barron

IPC分类号： A61K35/16 ,  A61L2/00

CPC分类号： A61K35/16 ,  A61L2/0023 ,  A61L2202/22

摘要： The spray dried plasma by the nature of its characteristics and the process by which it is made allows for a dried plasma with reduced pathogens. It has at least three aspects of pathogen reduction that results in a plasma product with reduced or no pathogens. The first aspect relates to a spray drying disposable and machine that eliminates or minimizes the introduction of pathogens into the spray drying process and is referred to as the anti-contamination process. The second aspect of pathogen reduction relates to the spray drying process and parameters that reduces pathogens that may be present in the donor plasma, and/or inhibit pathogen growth and/or pathogen proliferation introduced by the donor plasma. The third aspect results in reduced pathogens occurring during storage of the dried plasma wherein the manufacturing and storage conditions are such that pathogens are reduced, and/or pathogen growth and/or pathogen proliferation are inhibited.

公开(公告)号：US20240108767A1

公开(公告)日：2024-04-04

申请号：US18536905

申请日：2023-12-12

申请人： Cerus Corporation

发明人： Daniel CHURCH ,  LIoyd ISON ,  Seyhan AKKOYUN

IPC分类号： A61L2/00 ,  A61L2/24 ,  B01F31/00 ,  B01F35/221 ,  B01F35/32

CPC分类号： A61L2/007 ,  A61L2/24 ,  B01F31/00 ,  B01F35/2214 ,  B01F35/3204 ,  A61L2202/11 ,  A61L2202/14 ,  A61L2202/22 ,  B01F2101/23

摘要： Electronic devices for treating a biological fluid and methods of operating the devices are disclosed. In some embodiments, the electronic device includes a plurality of non-safety critical components, a first controller communicatively coupled to the plurality of non-safety critical components, a plurality of safety critical components, and a second controller communicatively coupled to the plurality of safety critical components. In some embodiments, the electronic device includes a treatment interface.

公开(公告)号：US20240024556A1

公开(公告)日：2024-01-25

申请号：US17814537

申请日：2022-07-25

申请人： William M. Gosney ,  Dale B. Nixon

发明人： William M. Gosney ,  Dale B. Nixon

IPC分类号： A61M1/36 ,  A61L2/00

CPC分类号： A61M1/3681 ,  A61L2/0047 ,  A61M2205/3306 ,  A61M2205/702 ,  A61L2202/22

摘要： An operational unit for locating and neutralizing pathogen cells in blood includes a cassette which has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates the holding chambers and passes light to an underlying sensor array such that the cells in the blood selectively block the light to produce shadow images of the cells. A processor performs pattern recognition to locate the pathogen cells by use of an image library. After the pathogen cells are located, a source of ultraviolet light is activated and UV light is passed through selectively controlled shutters to illuminate only the limited areas that have the identified pathogen cells. Sufficient ultraviolet light energy is applied to destroy the identified cells. A pump refills the cassette holding chambers, returns the neutralized-pathogen blood to the patient, and the process is repeated.

公开(公告)号：US11801336B1

公开(公告)日：2023-10-31

申请号：US17814542

申请日：2022-07-25

申请人： William M. Gosney ,  Dale B. Nixon

发明人： William M. Gosney ,  Dale B. Nixon

IPC分类号： A61M1/36 ,  A61L2/00 ,  A61M60/113 ,  A61M60/36 ,  A61M60/279

CPC分类号： A61M1/36226 ,  A61L2/0011 ,  A61M1/3672 ,  A61M60/113 ,  A61M60/279 ,  A61M60/36 ,  A61L2202/22

摘要： An operational unit for locating and neutralizing pathogen cells in blood includes a time use cassette which has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood selectively block the light to produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, an electric field is activated in the cassette chamber areas that include the identified pathogen cells. Sufficient electric field energy is applied to destroy the identified pathogen cells. A pump refills the cassette holding chambers, returns the neutralized-pathogen blood to the patient, and the process is repeated for a period of time.

公开(公告)号：US20230226232A1

公开(公告)日：2023-07-20

申请号：US18084344

申请日：2022-12-19

申请人： Cerus Corporation

发明人： Daniel CHURCH ,  Peter BRINGMANN ,  Grace CASTRO ,  Thea LU ,  Shelby REINHARDT ,  Felicia SANTA MARIA ,  Adonis STASSINOPOULOS

IPC分类号： A61L2/00 ,  A61K31/37 ,  A01N1/02 ,  B01J19/12 ,  H01L25/075 ,  A61K41/17 ,  A61M1/36 ,  A61L2/26

CPC分类号： A61L2/0047 ,  A01N1/0215 ,  A01N1/0294 ,  A61K31/37 ,  A61K41/17 ,  A61L2/26 ,  A61L2/0076 ,  A61M1/3683 ,  B01J19/123 ,  H01L25/0753 ,  A61L2/24 ,  A61L2202/11 ,  A61L2202/14 ,  A61L2202/22

摘要： Provided are systems and methods for treating a biological fluid, e.g., to inactivate pathogens.

公开(公告)号：US20230190935A1

公开(公告)日：2023-06-22

申请号：US18085597

申请日：2022-12-21

申请人： Institute of Blood Transfusion CAMS

发明人： Zhong LIU ,  Yundi YIN ,  Ling LI ,  Haixia XU

IPC分类号： A61K41/17

CPC分类号： A61K41/17 ,  A61L2202/22

摘要： The present disclosure provides a pathogen inactivation method, which is low-frequency sonication together with illumination of a photosensitizer-containing blood sample; and the low-frequency sonication is conducted at a frequency of 15-500 KHz. Through the combination of sonication and photochemical pathogen inactivation technology that enhance and complement each other, the blood pathogen inactivation method provided by the present disclosure enhances a pathogen inactivation effect, reduces a dosage of the photosensitizer, photosensitizer-related blood quality damage, energy demand for the illumination, and pathogen inactivation treatment time, increases the blood illumination thickness for effective pathogen inactivation, saves illumination bag materials, shortens the size of illumination equipment, saves costs, and helps the pathogen inactivation technology go to the market.

公开(公告)号：US11642487B2

公开(公告)日：2023-05-09

申请号：US17060970

申请日：2020-10-01

申请人： Applied Research Associates, Inc.

发明人： Brian K. Heimbuch ,  Delbert A. Harnish ,  Geoffrey A. Kibble ,  Thomas B. Stephenson ,  Sheila J. Nogueira-Prewitt ,  Christopher G. Estkowski ,  Johnnie H. Copley ,  Graham Wilson ,  Chris Ward

IPC分类号： A61M16/10 ,  A61M16/06 ,  A61L2/20 ,  A61L2/00

CPC分类号： A61M16/1065 ,  A61L2/0035 ,  A61L2/206 ,  A61M16/0605 ,  A61M16/0683 ,  A61L2202/22 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2209/088

摘要： A reusable respirator including a mask adapted for covering and conforming to the face around the nose and a mouth of a user, a strap configured to secure the mask to a face of the user, and a filter component. All components of the respirator are capable of being cleaned, disinfected and sterilized at temperatures in excess of 50° C. An outer surface of the mask is substantially smooth and wettable for easily disinfecting and is shaped with a pair of outer shield portions for housing particulate air filters. The outer shield portions each include a closeable vent through the outer surface that is adapted to provide a user seal check and direct air flow through the outer surface for filtering by the respective particulate air filter, which is adapted to filter at least 95% of airborne particles.

公开(公告)号：US20180353629A9

公开(公告)日：2018-12-13

申请号：US15645480

申请日：2017-07-10

申请人： S. Edward Neister ,  John James Rowsey

发明人： S. Edward Neister ,  John James Rowsey

IPC分类号： A61L2/00 ,  A61N5/06

CPC分类号： A61L2/0047 ,  A23B7/015 ,  A23L3/26 ,  A23L3/28 ,  A61L2/0011 ,  A61L2/10 ,  A61L9/20 ,  A61L2202/22 ,  A61N5/0624 ,  A61N2005/063 ,  A61N2005/0654 ,  A61N2005/0661 ,  B08B17/00

摘要： This invention relates to a method, process and apparatus for disinfecting and sterilizing all types of surfaces contaminated with microorganisms and toxic substances to render both inactive. Furthermore, this invention relates to both a method and apparatus for disinfecting and/or sterilizing breathable air and then using this air to protect a confined space from external contamination. The apparatus consists of a new ultra-violet (NUV) source that is more effective than mercury based 254 nm light for destroying DNA of virus, bacteria, spores and cists. It is most effective in breaking chemical bonds in toxic gases and Biotoxins that are useful to terrorists. It is combined with other apparatus that remove particulates and byproducts sometimes produced by the NUV source and maintains positive pressure of the confined space so as to prevent the influx of air from outside the protected zone.