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    Identification of Hla-A2-Presented T-Cell Epitopes Derived from the Oncofoetal Antigen-Immature Laminin Receptor Protein and Uses Thereof
    1.
    发明申请
    Identification of Hla-A2-Presented T-Cell Epitopes Derived from the Oncofoetal Antigen-Immature Laminin Receptor Protein and Uses Thereof 有权
    鉴定从原生抗原不成体层粘连蛋白受体蛋白衍生的Hla-A2呈递的T细胞表位及其用途

    公开(公告)号：US20090041794A1

    公开(公告)日：2009-02-12

    申请号：US11912668

    申请日：2006-04-26

    申请人： Matthias Zeis

    发明人： Matthias Zeis

    IPC分类号： A61K39/00 ,  A61K38/08 ,  C07K7/06 ,  C07K7/08 ,  C12N5/08 ,  C07K14/47 ,  C12N15/63 ,  C12P21/02

    CPC分类号： C07K14/4748

    摘要： The present invention relates to the immunotherapB of cancer, in particular several tumor entities including hematological malignancies. The present invention relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. In particular, the present invention relates to two novel peptide sequences derived from HLA class I or II molecules of human oncofoetal antigen immature laminin receptor (OFA/iLR), which can be used in vaccine compositions for eliciting anti-tumor immune responses.

    摘要翻译： 本发明涉及癌症的免疫疗法，尤其涉及包括血液恶性肿瘤在内的几种肿瘤实体。 本发明涉及用作刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的单独或与其它肿瘤相关肽组合的肿瘤相关T辅助细胞肽表位。 特别地，本发明涉及可以用于诱导抗肿瘤免疫应答的疫苗组合物中的两种来源于人类抗原成熟层粘连蛋白受体（OFA / iLR）的I类或II类HLA分子的新型肽序列。

    Identification of Hla-A2-presented T-cell epitopes derived from the oncofoetal antigen-immature laminin receptor protein and uses thereof
    2.
    发明授权
    Identification of Hla-A2-presented T-cell epitopes derived from the oncofoetal antigen-immature laminin receptor protein and uses thereof 有权
    鉴定来源于oncofoetal抗原 - 未成熟层粘连蛋白受体蛋白的Hla-A2呈递的T细胞表位及其用途

    公开(公告)号：US07968097B2

    公开(公告)日：2011-06-28

    申请号：US11912668

    申请日：2006-04-26

    申请人： Matthias Zeis

    发明人： Matthias Zeis

    IPC分类号： A61K38/00 ,  A61K38/04 ,  A61K39/00 ,  C07K7/00 ,  C07K17/00

    CPC分类号： C07K14/4748

    摘要： The present invention relates to the immunotherapB of cancer, in particular several tumor entities including hematological malignancies. The present invention relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. In particular, the present invention relates to two novel peptide sequences derived from HLA class I or II molecules of human oncofoetal antigen immature laminin receptor (OFA/iLR), which can be used in vaccine compositions for eliciting anti-tumor immune responses.

    摘要翻译： 本发明涉及癌症的免疫疗法，尤其涉及包括血液恶性肿瘤在内的几种肿瘤实体。 本发明涉及用作刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的单独或与其它肿瘤相关肽组合的肿瘤相关T辅助细胞肽表位。 特别地，本发明涉及可以用于诱导抗肿瘤免疫应答的疫苗组合物中的两种来源于人类抗原成熟层粘连蛋白受体（OFA / iLR）的I类或II类HLA分子的新型肽序列。