公开(公告)号：US20060263458A1

公开(公告)日：2006-11-23

申请号：US11412659

申请日：2006-04-27

申请人： May Mak ,  Pui-Kwong Chan

发明人： May Mak ,  Pui-Kwong Chan

IPC分类号： A61K36/77

CPC分类号： A61K36/77

摘要： This invention provides a process of producing extract comprises growth-stimulation components from husks, kernels, leaves, fruit-stems, branches, stems, roots, seed's shells and barks and their applications. A use of composition comprising the extract from the husks, kernels, leaves, fruit-stems, branches, stems, roots, seed's shells and barks of Wenguanguo for stimulating the cell aactivities comprising growth-stimulation by administering an appropriate amount of the above composition.

摘要翻译： 本发明提供一种生产提取物的方法，其包括来自果壳，籽粒，叶，果实，分枝，茎，根，种子壳和树皮的生长刺激成分及其应用。 包含通过施用适量的上述组合物来刺激包括生长刺激的细胞活性的组合物的组合物的组合物，其包含来自外壳，籽粒，叶，果实茎，枝，茎，根，种子的壳和贝壳的提取物。

公开(公告)号：US20050276872A1

公开(公告)日：2005-12-15

申请号：US11117760

申请日：2005-04-27

申请人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

IPC分类号： A23L1/30 ,  A61K36/00 ,  A61K36/33 ,  A61K36/77 ,  A61K35/78

CPC分类号： A23L1/3002 ,  A23L33/105 ,  A23L33/11 ,  A23V2002/00 ,  A61K36/00 ,  A61K36/77 ,  C07H15/256 ,  C07J63/00 ,  A61K2300/00 ,  A23V2200/30 ,  A23V2200/308 ,  A23V2250/2116

摘要： This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attache to Carbon 21 or/and 22, or/and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

摘要翻译： 本发明提供了从Xanthoceras sorbifolia生产提取物和纯化合物的组合物，方法和方法。 提取物包括皂苷和其他成分，包括生物碱，香豆素，糖类，蛋白质，多糖，糖苷，单宁，酸，类黄酮等。 该组合物可用于治疗关节炎，风湿病，循环不良，动脉硬化，雷诺综合征，心绞痛，心脏病，冠心病，头痛，肾脏疾病和阳treating等癌症和其他病症。 改善脑功能; 或用于治疗遗尿，频繁排尿，尿失禁，痴呆，弱智能和阿尔茨海默病，自闭症，脑外伤，帕金森病，脑功能障碍和治疗关节炎，风湿病，循环不良，动脉硬化，雷诺综合征，心绞痛，心脏病，头痛 ，头晕，肾脏疾病。 本发明提供了本质上的油酸三萜皂苷的化合物，其特征在于至少一个异酰基与碳21或/和22连接或/并连接至糖。 本发明的化合物具有各种药物和治疗应用。

公开(公告)号：US20050245470A1

公开(公告)日：2005-11-03

申请号：US11117745

申请日：2005-04-27

申请人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

IPC分类号： A61K31/704 ,  C07H15/24

CPC分类号： C07H15/256 ,  A61K36/77 ,  C07H15/24 ,  C07J63/00

摘要： Novel compounds such as compounds designated herein as Y or Y3, Y1, Y2, Y8, Y9 and Y10 are disclosed. These compounds have anticancer activity. The compounds of the present invention are obtainable from plants in the sapindaceae family, such as Xanthoceras sorbifolia, or other natural sources or products. The compounds of the present invention may also be synthesized chemically.

摘要翻译： 公开了本文中称为Y或Y 3，Y 1，Y 2，Y 8，Y 9和Y 10的新化合物。 这些化合物具有抗癌活性。 本发明的化合物可从诸如山楂科的植物中获得，或其它天然来源或产品。 本发明的化合物也可以化学合成。

公开(公告)号：US20050277601A1

公开(公告)日：2005-12-15

申请号：US11131551

申请日：2005-05-17

申请人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

IPC分类号： A61K31/704 ,  C07H15/24

CPC分类号： C07H15/24 ,  A61K36/77 ,  C07H15/256 ,  C07J63/00

摘要： Novel compounds such as compounds designated herein as Xanifolia-Y or -Y3, -Y1, -Y2, -Y8, -Y9 and -Y10 are disclosed. These compounds have anticancer activity. The compounds of the present invention are obtainable from plants in the sapindaceae family, such as Xanthoceras sorbifolia, or other natural sources or products. The compounds of the present invention may also be synthesized chemically.

摘要翻译： 公开了新的化合物，例如本文命名为Xanifolia-Y或-Y3，-Y1，-Y2，-Y8，-Y9和-Y10的化合物。 这些化合物具有抗癌活性。 本发明的化合物可从诸如山楂科的植物中获得，或其它天然来源或产品。 本发明的化合物也可以化学合成。

公开(公告)号：US20070161580A1

公开(公告)日：2007-07-12

申请号：US11683198

申请日：2007-03-07

申请人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

IPC分类号： A61K31/704 ,  C07H15/24

CPC分类号： C07H15/24 ,  C07J63/008

摘要： This invention provides a method for treating cancer by blocking the migration, metastasis of cancer cells, growth of cancers wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer. This invention provides uses of compositions comprising a triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin, comprising at least two side groups selected from the group consisting of angeloyl groups, tigloyl groups and senecioyl groups, wherein the side groups are attached to carbon 21, 22 or/and 28 of triterpenoidal sapogenin, triterpenoid, triterpenoidal compound or other sapongenin backbones.

摘要翻译： 本发明提供了一种通过阻断癌细胞的迁移，转移，癌细胞生长的方法，其中癌症包括乳腺癌，白细胞癌，肝癌，卵巢癌，膀胱癌，前列腺癌，皮肤癌，骨癌，脑 癌症，白血病癌症，肺癌，结肠癌，CNS癌，黑素瘤，肾癌或宫颈癌。 本发明提供了包含三萜皂苷，三萜，三萜化合物或皂甙元的组合物的用途，所述组合物包含至少两个侧基，所述侧基选自阴离子基，二酰基和亚磺酰基，其中所述侧基连接到碳21,22 或/和28的三萜皂苷元，三萜，三萜化合物或其他皂草宁骨架。

公开(公告)号：US20060122129A1

公开(公告)日：2006-06-08

申请号：US11289142

申请日：2005-11-28

申请人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

IPC分类号： A61K31/704 ,  C07H15/24

CPC分类号： A61K31/575 ,  A61K31/7012 ,  A61K31/704 ,  A61K36/77 ,  C07C2603/52 ,  C07H15/24 ,  C07H15/256 ,  C07J9/00

摘要： This invention provides composition comprising a triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin, comprising at least two side groups selected from the group consisting of: angeloyl groups, tigloyl groups and senecioyl groups, wherein the side groups are attached to carbon 21, 22 or/and 28 of triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin backbone. This invention provides a composition for inhibiting tumor cell growth, comprising an appropriate amount of a triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin, wherein the triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin comprises any two side groups selected from the group consisting of: angeloyl groups, tigloyl groups and senecioyl groups, wherein the side groups are attached to carbon 21, 22 or/and 28 of triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin backbone.

摘要翻译： 本发明提供了包含三萜皂苷，三萜，三萜化合物或皂甙元的组合物，其包含至少两个选自以下的侧基基团：阴离子基团，二酰基基团和间甲酰基基团，其中侧基基团连接到碳21,22或 /和28的三萜皂苷，三萜，三萜化合物或皂甙元骨架。 本发明提供了一种抑制肿瘤细胞生长的组合物，其包含适量的三萜皂苷，三萜类，三萜化合物或皂甙元，其中三萜皂苷，三萜类，三萜化合物或皂甙元包括选自以下的任何两个侧基： 正己酰基，二酰基和十一烷酰基，其中侧基连接到三萜皂苷，三萜，三萜化合物或皂甙元主链的碳21,22或/和28上。

公开(公告)号：US20060111310A1

公开(公告)日：2006-05-25

申请号：US11267523

申请日：2005-11-04

申请人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

发明人： Pui-Kwong Chan ,  May Mak ,  Yun Wang

IPC分类号： C07H15/24 ,  A61K31/704

CPC分类号： C07H15/24

摘要： This invention provides a compound comprising a triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin, comprising at least two side groups selected from the group consisting of: angeloyl groups, tigloyl groups and senecioyl groups, wherein the side groups are attached to carbon 21, 22 or/and 28 of triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin backbone. This invention provides a composition for inhibiting tumor cell growth, comprising an appropriate amount of a triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin, wherein the triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin comprises any two side groups selected from the group consisting of: angeloyl groups, tigloyl groups and senecioyl groups, wherein the side groups are attached to carbon 21, 22 or/and 28 of triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin backbone.

摘要翻译： 本发明提供一种包含三萜皂苷，三萜类，三萜化合物或皂甙元的化合物，其包含至少两个选自以下的侧基基团：阴离子基团，二酰基基团和亚磺酰基基团，其中所述侧基连接到碳21,22上 或/和28的三萜皂苷，三萜，三萜化合物或皂甙元骨架。 本发明提供了一种抑制肿瘤细胞生长的组合物，其包含适量的三萜皂苷，三萜类，三萜化合物或皂甙元，其中三萜皂苷，三萜类，三萜化合物或皂甙元包括选自以下的任何两个侧基： 正己酰基，二酰基和十一烷酰基，其中侧基连接到三萜皂苷，三萜，三萜化合物或皂甙元主链的碳21,22或/和28上。