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公开(公告)号：US10677806B2
公开(公告)日：2020-06-09
申请号：US16233695
申请日：2018-12-27
申请人： MEDICINAL BIOCONVERGENCE RESEARCH CENTER , THE ASAN FOUNDATION , UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
发明人： Sunghoon Kim , Won Suk Yang , Kyunggon Kim , Won Gu Kim
IPC分类号： G01N33/53 , G01N33/78 , G01N33/573 , G01N33/574
摘要： A method for diagnosing follicular thyroid carcinoma is described. The method measures protein expression levels of an aminoacyl-tRNA synthetase (ARS) or an aminoacyl-tRNA synthetase complex-interacting multifunctional protein (AIMP) in a sample, such as a thyroid tissue sample, from a subject suspected of having follicular thyroid carcinoma. The protein expression levels of ARS or AIMP are compared to the measured protein expression levels in a control.
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公开(公告)号：US20190277865A1
公开(公告)日：2019-09-12
申请号：US16233695
申请日：2018-12-27
申请人： MEDICINAL BIOCONVERGENCE RESEARCH CENTER , THE ASAN FOUNDATION , UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
发明人： Sunghoon Kim , Won Suk Yang , Kyunggon Kim , Won Gu Kim
IPC分类号： G01N33/78 , G01N33/573
摘要： The present invention relates to a method for detecting markers for diagnosis of follicular thyroid carcinoma using an expression level of aminoacyl-tRNA synthetase-related protein. More specifically, the present invention relates to a method for detecting markers of follicular carcinoma in order to provide necessary for the diagnosis of follicular thyroid carcinoma in a patient suspected of having follicular thyroid carcinoma, the method comprising; (a) a step of providing a sample from a subject suspected of having follicular thyroid carcinoma; (b) a step of measuring the protein expression of an aminoacyl-tRNA synthetase or an aminoacyl-tRNA synthetase complex-interacting multifunctional protein in the sample; and (c) a step of comparing the measured protein expression level with that of a control, and determining that the subject having a confirmed change in the protein expression level has follicular thyroid carcinoma. Specifically, the types of proteins disclosed in the present invention can be used to diagnose follicular thyroid carcinoma simply and clearly without surgical tissue retrieval, and have high diagnostic sensitivity and specificity
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公开(公告)号：US09539236B2
公开(公告)日：2017-01-10
申请号：US14727146
申请日：2015-06-01
发明人： Sunghoon Kim , Nam Hoon Kwon , Dae Gyu Kim
IPC分类号： C07D273/01 , A61K31/395
CPC分类号： A61K31/395 , C07D273/01
摘要： Exemplary embodiments relate to a novel anticancer composition including a compound represented by chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient:
摘要翻译： 本发明涉及一种新型抗癌组合物，更具体地涉及：抗癌药物组合物，其包含由化学式1表示的化合物或其药学上可接受的盐; 一种预防或治疗癌症的方法，包括向有需要的个体施用有效量的由化学式1表示的化合物或其药学上可接受的盐的步骤; 以及由化学式1表示的化合物或其药学上可接受的盐在制备用于预防或治疗癌症的药剂中的用途。 本发明的化合物依赖于浓度来抑制在肺癌细胞中过表达的AIMP2-DX2的蛋白质水平，并且依赖于浓度而不影响癌细胞的存活而不作用于正常细胞，因此 包含本发明化合物或其可药用盐的药物组合物可用于预防和治疗癌症。
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公开(公告)号：US20160195533A1
公开(公告)日：2016-07-07
申请号：US14670390
申请日：2015-03-26
发明人： Byung-Gyu KIM , Ji-Ae Song , Sunghoon Kim
IPC分类号： G01N33/573
CPC分类号： C12Q1/44 , G01N2333/922 , G01N2500/02
摘要： A method for screening an EMT inhibitor including: contacting EPRS, Snail1 protein, and a test agent; and measuring a change in a binding level between the EPRS and the Snail1 protein.
摘要翻译： 一种用于筛选EMT抑制剂的方法，包括：接触EPRS，Snail1蛋白和测试剂; 并测量EPRS和Snail1蛋白之间的结合水平的变化。
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公开(公告)号：US11029504B2
公开(公告)日：2021-06-08
申请号：US15756394
申请日：2016-08-31
发明人： Pil Han Kim , Yeseul Kim , Inwon Park , Sunghoon Kim
摘要： Disclosed are a window apparatus for obtaining a microscopic image of in vivo breast tissue and a method for using the window apparatus to obtain cell-level and molecular-level microscopic images of in vivo breast tissue while maintaining the biological environment of the in vivo breast tissue. In one embodiment, a window apparatus comprises a first chamber having a ring structure with an open window on the center, and a cover glass disposed on the upper part and breast tissue placed on the lower part; a second chamber having an opening window on the center coupled to the first chamber to support the breast tissue; and a chamber holder for fixing the first and second chambers having a tilting mount placing unit with the tilting mount placed to have the cover glass and an object lens of a confocal microscope system stay parallel to each other.
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6.发明申请公开(公告)号：US20180235476A1
公开(公告)日：2018-08-23
申请号：US15756394
申请日：2016-08-31
发明人： Pil Han KIM , Yeseul KIM , Inwon PARK , Sunghoon KIM
CPC分类号： A61B5/0091 , A61B5/00 , A61B90/25 , A61B2503/40 , A61B2562/0233 , G02B21/0028 , G02B21/0032 , G02B21/0076 , G02B21/02 , G02B21/26 , G02B21/34
摘要： Disclosed are a window apparatus for obtaining a microscopic image of in vivo breast tissue and a method for using the window apparatus to obtain cell-level and molecular-level microscopic images of in vivo breast tissue while maintaining the biological environment of the in vivo breast tissue. In one embodiment, a window apparatus comprises a first chamber having a ring structure with an open window on the center, and a cover glass disposed on the upper part and breast tissue placed on the lower part; a second chamber having an opening window on the center coupled to the first chamber to support the breast tissue; and a chamber holder for fixing the first and second chambers having a tilting mount placing unit with the tilting mount placed to have the cover glass and an object lens of a confocal microscope system stay parallel to each other.
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公开(公告)号：US20180221448A1
公开(公告)日：2018-08-09
申请号：US15745217
申请日：2016-07-13
发明人： Sunghoon KIM , Min Chul PARK , Byung Woo HAN , Joon-Sung PARK
IPC分类号： A61K38/19 , C07K14/52 , G01N33/574 , G01N33/58
CPC分类号： A61K38/19 , C07K14/52 , C07K2319/24 , C07K2319/50 , G01N33/50 , G01N33/574 , G01N33/58 , G01N33/6863 , G01N2333/521 , G01N2800/12 , G01N2800/7095
摘要： The present invention relates to a novel polypeptide having chemokine activity and, more specifically, to a polypeptide composed of the amino acid sequence represented by SEQ ID NO: 1 and a use thereof. The polypeptide of the present invention is composed of SEQ ID NO: 1 and exhibits chemokine activity through the binding with CCR3, and thus, the polypeptide has a high utilization effect for various purposes, such as immunoregulation, and diagnosis, treatment, and medicine development for CCR3-mediated diseases or disease symptoms.
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公开(公告)号：US20160377619A1
公开(公告)日：2016-12-29
申请号：US15198337
申请日：2016-06-30
发明人： Sunghoon Kim , Yon-Sik Choi , Hyunbo Shim , Nam Ju Lee , Min Hwa Park
IPC分类号： G01N33/573 , G01N33/574 , G01N33/564 , C07K16/40
CPC分类号： G01N33/573 , C07K16/40 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/564 , G01N33/57488
摘要： The present invention relates to an anti-lysyl-tRNA synthetase (KRS) antibody selectively binding to KRS, and a use thereof and, more specifically, to an antibody binding to human KRS or a fragment thereof, a method for producing the same, and a composition containing the same for diagnosing cancer, autoimmune diseases or inflammatory diseases. The antibody or fragment thereof of the present invention specifically binds to human KRS, and enables KRS detection and inhibition due to the absence of cross-linkage reactivity with the other proteins including the same ARS family, and thus the antibody or fragment thereof can be used to detect KRS and diagnose KRS-related diseases, i.e., cancer, autoimmune diseases or inflammatory diseases.
摘要翻译： 本发明涉及选择性结合KRS的抗赖氨酰tRNA合成酶（KRS）抗体及其用途，更具体地涉及与人KRS或其片段结合的抗体，其制备方法和 包含其用于诊断癌症，自身免疫性疾病或炎性疾病的组合物。 本发明的抗体或其片段特异性结合人KRS，由于与包括相同ARS家族的其它蛋白质不存在交联反应性，因此可以使用KRS检测和抑制，因此可以使用抗体或其片段 检测KRS并诊断KRS相关疾病，即癌症，自身免疫性疾病或炎性疾病。
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公开(公告)号：US09206132B2
公开(公告)日：2015-12-08
申请号：US14518753
申请日：2014-10-20
发明人： Sunghoon Kim , Hee Sook Lee , Young Sun Oh , Dae Gyu Kim
IPC分类号： C07D213/75 , A61K31/435 , C07D215/38
CPC分类号： C07D215/38 , A61K31/435 , C07D213/75
摘要： An aminopyridine derivative of Formula 1 and a method of preventing or treating cancer using the same. Formula 1: In Formula 1: X1 and X2 are each independently selected from the group consisting of carbon and nitrogen; R1 to R5 are each independently selected from the group consisting of a hydrogen, a straight, a branched, or cyclo alkyl of C1-C4, a halogen, and a hydroxyl; and R6 is a hydrogen or an alkyl of C1-C6.
摘要翻译： 式1的氨基吡啶衍生物和使用其的预防或治疗癌症的方法。 式1：在式1中，X 1和X 2各自独立地选自碳和氮; R 1至R 5各自独立地选自C 1 -C 4的氢，直链，支链或环烷基，卤素和羟基; 并且R 6是氢或C 1 -C 6的烷基。
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10.发明授权公开(公告)号：US10258674B2
公开(公告)日：2019-04-16
申请号：US15362196
申请日：2016-11-28
发明人： Sunghoon Kim , Min Chul Park
摘要： The present invention relates to nanoparticles comprising aminoacyl tRNA synthetase and an anticancer composition comprising the same and, specifically, to nanoparticles which comprise glycyl-tRNA synthetase (GRS), leucyl-tRNA synthetase (LRS), and isoleucyl-tRNA synthetase (IRS), and have anticancer or immunostimulating activity; a pharmaceutical composition for preventing or treating cancer, comprising the nanoparticles as an active ingredient; a composition for immunostimulation; and a method for preparing the nanoparticles.
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