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    ANTI-KRS MONOCLONAL ANTIBODY AND USE THEREOF
    1.
    发明申请
    ANTI-KRS MONOCLONAL ANTIBODY AND USE THEREOF 有权
    抗-KRS单克隆抗体及其用途

    公开(公告)号：US20160377619A1

    公开(公告)日：2016-12-29

    申请号：US15198337

    申请日：2016-06-30

    申请人： Medicinal Bioconvergence Research Center

    发明人： Sunghoon Kim ,  Yon-Sik Choi ,  Hyunbo Shim ,  Nam Ju Lee ,  Min Hwa Park

    IPC分类号： G01N33/573 ,  G01N33/574 ,  G01N33/564 ,  C07K16/40

    CPC分类号： G01N33/573 ,  C07K16/40 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  G01N33/564 ,  G01N33/57488

    摘要： The present invention relates to an anti-lysyl-tRNA synthetase (KRS) antibody selectively binding to KRS, and a use thereof and, more specifically, to an antibody binding to human KRS or a fragment thereof, a method for producing the same, and a composition containing the same for diagnosing cancer, autoimmune diseases or inflammatory diseases. The antibody or fragment thereof of the present invention specifically binds to human KRS, and enables KRS detection and inhibition due to the absence of cross-linkage reactivity with the other proteins including the same ARS family, and thus the antibody or fragment thereof can be used to detect KRS and diagnose KRS-related diseases, i.e., cancer, autoimmune diseases or inflammatory diseases.

    摘要翻译： 本发明涉及选择性结合KRS的抗赖氨酰tRNA合成酶（KRS）抗体及其用途，更具体地涉及与人KRS或其片段结合的抗体，其制备方法和 包含其用于诊断癌症，自身免疫性疾病或炎性疾病的组合物。 本发明的抗体或其片段特异性结合人KRS，由于与包括相同ARS家族的其它蛋白质不存在交联反应性，因此可以使用KRS检测和抑制，因此可以使用抗体或其片段 检测KRS并诊断KRS相关疾病，即癌症，自身免疫性疾病或炎性疾病。