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公开(公告)号:US06991909B2
公开(公告)日:2006-01-31
申请号:US10375693
申请日:2003-02-25
申请人: Harvey Florman , Melissa Jungnickel , Keith Sutton
发明人: Harvey Florman , Melissa Jungnickel , Keith Sutton
IPC分类号: G01N33/53 , G01N33/537
CPC分类号: C07K14/47 , A61K38/00 , Y10T436/105831
摘要: A novel protein, enkurin, that is preferentially expressed in sperm has been discovered. Enkurin binds to TRPCs including TRPC2-S, a protein encoded by TRPC2 that is not predicted to be a calcium channel subunit. The invention includes methods of identifying compounds that affect enkurin expression or activity, and are useful, e.g., for contraception and treatment of infertility.
摘要翻译: 已经发现了优先在精子中表达的新蛋白质enkurin。 Enkurin结合TRPC,包括TRPC2-S,由TRPC2编码的蛋白质,其不被预测为钙通道亚基。 本发明包括鉴定影响enkurin表达或活性的化合物的方法,并且可用于例如避孕和治疗不育症。