公开(公告)号：US20090035314A1

公开(公告)日：2009-02-05

申请号：US11665195

申请日：2005-10-12

申请人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung

发明人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung

IPC分类号： A61K39/395 ,  A61K38/02 ,  A61K38/16 ,  C12Q1/02 ,  A61P29/00 ,  A61K31/7052

CPC分类号： A61K38/17 ,  A61K2039/505 ,  C07K16/18 ,  Y02A50/40

摘要： The present invention relates to a method and pharmaceutical composition for preventing or treating inflammatory diseases. More particularly, the present invention relates to a method for inhibiting lymphocyte adhesion to an endothelial cell, or a method for treating an inflammatory disease, which comprises administering to a subject in need thereof an inhibitor against lymphocyte adhesion to a FEX-2 polypeptide. A pharmaceutical composition comprising the inhibitor against lymphocyte adhesion to a FEX-2 polypeptide, and the use of the inhibitor against lymphocyte adhesion to a FEX-2 polypeptide are also disclosed. Further, a method for screening a medicament for inhibiting lymphocyte adhesion to a FEX-2 polypeptide or a medicament for treating an inflammatory disease, which comprises a step of selecting an inhibitor against lymphocyte adhesion to a FEX-2 polypeptide, is disclosed.

摘要翻译： 本发明涉及一种预防或治疗炎性疾病的方法和药物组合物。 更具体地说，本发明涉及抑制淋巴细胞对内皮细胞粘附的方法或治疗炎症性疾病的方法，其包括向有需要的受试者施用抑制淋巴细胞粘附于FEX-2多肽的抑制剂。 还公开了包含抗FEX-2多肽的淋巴细胞粘附抑制剂的药物组合物，以及使用该抗体对淋巴细胞粘附于FEX-2多肽的用途。 此外，公开了一种筛选用于抑制对FEX-2多肽的淋巴细胞粘附的药物或用于治疗炎性疾病的药物的方法，其包括选择抗FEX-2多肽的淋巴细胞粘附抑制剂的步骤。

公开(公告)号：US20090028871A1

公开(公告)日：2009-01-29

申请号：US11665190

申请日：2005-10-12

申请人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung ,  Ha-Jeong Kim

发明人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung ,  Ha-Jeong Kim

IPC分类号： A61K39/395 ,  A61K31/661 ,  G01N33/53 ,  A61P37/06

CPC分类号： A61K31/685 ,  Y02A50/40

摘要： The present invention relates to novel use of a ligand specific to a FEX-2 polypeptide. More specifically, the present invention relates to methods for modulating the secretion of an inflammation-associated cytokine and for treating or preventing an inflammatory disease using the FEX-2-specific ligand. The ligand specific to the FEX-2 polypeptide can bind to FEX-2 expressed on the surface of phagocytes so that it can stimulate the secretion of anti-inflammatory cytokine and inhibit the secretion of inflammatory cytokine, so as to treat or prevent inflammatory diseases.

摘要翻译： 本发明涉及FEX-2多肽特异性配体的新用途。 更具体地，本发明涉及用于调节炎症相关细胞因子的分泌以及使用FEX-2特异性配体治疗或预防炎性疾病的方法。 对FEX-2多肽特异性的配体可以结合在吞噬细胞表面上表达的FEX-2，从而可以刺激抗炎细胞因子的分泌并抑制炎性细胞因子的分泌，从而治疗或预防炎性疾病。