公开(公告)号：US20090035314A1

公开(公告)日：2009-02-05

申请号：US11665195

申请日：2005-10-12

申请人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung

发明人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung

IPC分类号： A61K39/395 ,  A61K38/02 ,  A61K38/16 ,  C12Q1/02 ,  A61P29/00 ,  A61K31/7052

CPC分类号： A61K38/17 ,  A61K2039/505 ,  C07K16/18 ,  Y02A50/40

摘要： The present invention relates to a method and pharmaceutical composition for preventing or treating inflammatory diseases. More particularly, the present invention relates to a method for inhibiting lymphocyte adhesion to an endothelial cell, or a method for treating an inflammatory disease, which comprises administering to a subject in need thereof an inhibitor against lymphocyte adhesion to a FEX-2 polypeptide. A pharmaceutical composition comprising the inhibitor against lymphocyte adhesion to a FEX-2 polypeptide, and the use of the inhibitor against lymphocyte adhesion to a FEX-2 polypeptide are also disclosed. Further, a method for screening a medicament for inhibiting lymphocyte adhesion to a FEX-2 polypeptide or a medicament for treating an inflammatory disease, which comprises a step of selecting an inhibitor against lymphocyte adhesion to a FEX-2 polypeptide, is disclosed.

摘要翻译： 本发明涉及一种预防或治疗炎性疾病的方法和药物组合物。 更具体地说，本发明涉及抑制淋巴细胞对内皮细胞粘附的方法或治疗炎症性疾病的方法，其包括向有需要的受试者施用抑制淋巴细胞粘附于FEX-2多肽的抑制剂。 还公开了包含抗FEX-2多肽的淋巴细胞粘附抑制剂的药物组合物，以及使用该抗体对淋巴细胞粘附于FEX-2多肽的用途。 此外，公开了一种筛选用于抑制对FEX-2多肽的淋巴细胞粘附的药物或用于治疗炎性疾病的药物的方法，其包括选择抗FEX-2多肽的淋巴细胞粘附抑制剂的步骤。

公开(公告)号：US20090028871A1

公开(公告)日：2009-01-29

申请号：US11665190

申请日：2005-10-12

申请人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung ,  Ha-Jeong Kim

发明人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung ,  Ha-Jeong Kim

IPC分类号： A61K39/395 ,  A61K31/661 ,  G01N33/53 ,  A61P37/06

CPC分类号： A61K31/685 ,  Y02A50/40

摘要： The present invention relates to novel use of a ligand specific to a FEX-2 polypeptide. More specifically, the present invention relates to methods for modulating the secretion of an inflammation-associated cytokine and for treating or preventing an inflammatory disease using the FEX-2-specific ligand. The ligand specific to the FEX-2 polypeptide can bind to FEX-2 expressed on the surface of phagocytes so that it can stimulate the secretion of anti-inflammatory cytokine and inhibit the secretion of inflammatory cytokine, so as to treat or prevent inflammatory diseases.

摘要翻译： 本发明涉及FEX-2多肽特异性配体的新用途。 更具体地，本发明涉及用于调节炎症相关细胞因子的分泌以及使用FEX-2特异性配体治疗或预防炎性疾病的方法。 对FEX-2多肽特异性的配体可以结合在吞噬细胞表面上表达的FEX-2，从而可以刺激抗炎细胞因子的分泌并抑制炎性细胞因子的分泌，从而治疗或预防炎性疾病。

公开(公告)号：US20090068189A1

公开(公告)日：2009-03-12

申请号：US11791043

申请日：2005-11-18

申请人： Eun-Hee Bae ,  In-San Kim ,  Dong-Sin Lee ,  Hee-Jeong Yun

发明人： Eun-Hee Bae ,  In-San Kim ,  Dong-Sin Lee ,  Hee-Jeong Yun

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/06 ,  A61K35/12 ,  A61P31/00 ,  G01N33/566 ,  G01N33/53 ,  C40B30/04

CPC分类号： C07K16/18 ,  C07K2317/76

摘要： The present invention relates to a monoclonal antibody to human βig-h3 and the use thereof. More particularly, it relates to a monoclonal antibody to the human βig-h3 protein, wherein the epitope of the monoclonal antibody is the H1 region of the fourth fas-1 domain of the human βig-h3 protein. The monoclonal antibody can specifically recognize the human βig-h3 protein in tissue, and so will be useful in diagnosing a disease associated with the increase or decrease of the βig-h3 protein. In addition, the monoclonal antibody has the effect of inhibiting the cell adhesion activity of the βig-h3 protein.

摘要翻译： 本发明涉及对人β-h3的单克隆抗体及其用途。 更具体地说，本发明涉及对人β-h3蛋白的单克隆抗体，其中单克隆抗体的表位是人β-h3蛋白的第四个fas-1结构域的H1区。 单克隆抗体可以特异性识别组织中的人βIG-h3蛋白，因此可用于诊断与βig-h3蛋白的增加或减少相关的疾病。 此外，单克隆抗体具有抑制β-h3蛋白的细胞粘附活性的作用。

公开(公告)号：US07396682B2

公开(公告)日：2008-07-08

申请号：US10276479

申请日：2000-12-08

申请人： In-San Kim ,  Jung-Eun Kim

发明人： In-San Kim ,  Jung-Eun Kim

IPC分类号： C12N5/00 ,  C07K2/00 ,  C07K14/00 ,  C07K17/02 ,  C07H21/04

CPC分类号： C07K14/78 ,  A61K38/00

摘要： The present invention relates to a method for cell adhesion and wound healing with internal domains of βig-h3. Particularly, the present invention relates to the method of using recombinant proteins comprising one or more of 2nd or 4th internal domain of βig-h3 for cell adhesion and wound healing, wherein the 2nd or 4th internal domain of βig-h3 has aspartic acid and isoleucine essential for interaction with integrin which represent a high homology in base sequence of βig-h3 internal domains. The recombinant proteins comprising one or more 2nd or 4th internal domain of βig-h3 are effective for cell adhesion and wound healing by itself and can be used for developing cell culture medium and wound healing agent.

摘要翻译： 本发明涉及一种细胞粘附和伤口愈合方法，内部结构域为β-h3。 特别地，本发明涉及使用包含βig-h3的第二和/或第四/第四内部结构域中的一个或多个的重组蛋白的方法用于细胞粘附和伤口愈合， 其中βig-h3的第二个或第四个或第四个内部结构域具有与整合素相互作用所必需的天冬氨酸和异亮氨酸，其表示βig-h3内部碱基序列的高度同源性 域名 包含β1-h3的一个或多个第二和/或第四/第四内部结构域的重组蛋白自身有效用于细胞粘附和伤口愈合，并且可用于开发细胞培养物 培养和伤口愈合剂。

公开(公告)号：US07250400B2

公开(公告)日：2007-07-31

申请号：US11307490

申请日：2006-02-09

申请人： In-San Kim ,  Jung-Eun Kim

发明人： In-San Kim ,  Jung-Eun Kim

IPC分类号： A61K38/00 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12P21/06 ,  C07K1/00

CPC分类号： A61K38/08 ,  C07K7/06 ,  C07K14/4718 ,  C07K14/78

摘要： The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL (SEQ ID NO:2) and EPDIM (SEQ ID NO:3) and derivatives thereof which promote the cell attachment activity through interaction with α3β1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing βig-h3, wound healing, tissue regeneration and metastasis inhibition.

摘要翻译： 本发明涉及具有细胞附着，扩散和分离活性的肽及其衍生物。 特别地，本发明涉及通过与作为功能性细胞受体的α3β1整联蛋白相互作用而促进细胞附着活性的肽NKDIL（SEQ ID NO：2）和EPDIM（SEQ ID NO：3）及其衍生物，包括天冬氨酸和 异亮氨酸对细胞附着和分离活性至关重要。 本发明的肽及其衍生物可用于开发通过含有β-h3的各种细胞外基质蛋白，伤口愈合，组织再生和转移抑制介导的细胞附着活性的研究。

公开(公告)号：US07745410B2

公开(公告)日：2010-06-29

申请号：US11979624

申请日：2007-11-06

申请人： Erkki Ruoslahti ,  Byung-Heon Lee ,  In-San Kim

发明人： Erkki Ruoslahti ,  Byung-Heon Lee ,  In-San Kim

IPC分类号： A61K38/08 ,  A61K39/395

CPC分类号： A61K38/08

摘要： The present invention relates to a bladder tumor-targeting peptide and use thereof. More particularly, the present invention relates to a bladder tumor-targeting peptide having an amino acid sequence represented by SEQ ID NO: 7 and use thereof. The peptide according to the present invention is capable of specific binding to bladder tumor cells in vivo and in vitro. The peptide according to the present invention or an antibody thereof is useful for a marker for the diagnosis of bladder tumors, and for a drug carrier targeting bladder tumor.

摘要翻译： 本发明涉及膀胱肿瘤靶向肽及其用途。 更具体地，本发明涉及具有由SEQ ID NO：7表示的氨基酸序列的膀胱肿瘤靶向肽及其用途。 根据本发明的肽在体内和体外能够特异性结合膀胱肿瘤细胞。 根据本发明的肽或其抗体可用于膀胱肿瘤的诊断标记物和靶向膀胱肿瘤的药物载体。

公开(公告)号：US20080015150A1

公开(公告)日：2008-01-17

申请号：US11777245

申请日：2007-07-12

申请人： In-San Kim ,  Jung-Eun Kim

发明人： In-San Kim ,  Jung-Eun Kim

IPC分类号： A61K38/00

CPC分类号： A61K38/08 ,  C07K7/06 ,  C07K14/4718 ,  C07K14/78

摘要： The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL and EPDIM and derivatives thereof which promote the cell attachment activity through interaction with α 3β 1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing β ig-h3, wound healing, tissue regeneration and metastasis inhibition.

摘要翻译： 本发明涉及具有细胞附着，扩散和分离活性的肽及其衍生物。 特别地，本发明涉及通过与作为功能性细胞受体的α3β1整联蛋白相互作用而促进细胞附着活性的肽NKDIL和EPDIM及其衍生物，并且包括对于细胞附着和分离活性至关重要的天冬氨酸和异亮氨酸。 本发明的肽及其衍生物可用于开发通过含有βig-h3的各种细胞外基质蛋白，伤口愈合，组织再生和转移抑制介导的细胞附着活性的研究。

公开(公告)号：US20050164197A1

公开(公告)日：2005-07-28

申请号：US10511719

申请日：2002-10-22

申请人： In-San Kim ,  Jong-Sub Bae

发明人： In-San Kim ,  Jong-Sub Bae

IPC分类号： G01N33/53 ,  C07K14/705 ,  C12N15/09 ,  G01N33/566 ,  G01N33/68 ,  G01N37/00 ,  C12Q1/68

CPC分类号： G01N33/6887 ,  G01N2333/78

摘要： The present invention relates to the method for measuring the amount of βig-h3 protein and diagnostic kit using the same. Particularly, it relates to the method for measuring the amount of βig-h3 protein in the body fluids by specific binding reaction between βig-h3 protein or recombinant proteins of fas-1 domain in the βig-h3 protein (including their fragments or their derivatives) and their ligands and relates to diagnostic kit for the renal diseases, hepatic diseases, rheumatoid arthritis or cardiovascular diseases comprising βig-h3 protein or recombinant proteins of fas-1 domain in the βig-h3 protein (including their fragments or their derivatives) and their ligands. The method and kit of the present invention can be effectively used as sensitive diagnostic method for the extent of damage or progress of the renal diseases, hepatic diseases, rheumatoid arthritis or cardiovascular diseases.

摘要翻译： 本发明涉及测量βGG-3蛋白的量的方法及使用其的诊断试剂盒。 特别涉及通过beta-h3蛋白或β-h3蛋白（包括其片段或衍生物）中fas-1结构域的重组蛋白之间的特异性结合反应来测量体液中β-h3蛋白的量的方法 ）及其配体，涉及包含betaig-h3蛋白或β-h3蛋白（包括其片段或其衍生物）中fas-1结构域的重组蛋白的肾脏疾病，肝脏疾病，类风湿性关节炎或心血管疾病的诊断试剂盒，以及 它们的配体。 本发明的方法和试剂盒可以有效地用作肾脏疾病，肝脏疾病，类风湿性关节炎或心血管疾病的损伤或进展程度的敏感诊断方法。

公开(公告)号：US08133971B2

公开(公告)日：2012-03-13

申请号：US12391857

申请日：2009-02-24

申请人： Byung-Heon Lee ,  In-San Kim ,  Thapa Narendra

发明人： Byung-Heon Lee ,  In-San Kim ,  Thapa Narendra

IPC分类号： C07K5/10

CPC分类号： G01N33/57492 ,  A61K47/64 ,  A61K49/0043 ,  C07K7/06 ,  G01N33/92 ,  G01N2405/04 ,  G01N2510/00 ,  Y02A50/58

摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.

摘要翻译： 本发明涉及与磷脂酰丝氨酸特异性结合的多肽及其用途，更具体地说涉及具有指定为序列号1并特异性结合磷脂酰丝氨酸的氨基酸序列的多肽，含有多肽作为活性成分的磷脂酰丝氨酸检测组合物， 通过使用多肽检测磷脂酰丝氨酸的方法，包含多肽作为活性成分的凋亡细胞检测，含有多肽作为活性成分的药物递送组合物，用于治疗和预防肿瘤性疾病的组合物，以及用于可视化的组合物 肿瘤区。 具有指定为序列号1的氨基酸序列的多肽与磷脂酰丝氨酸具体结合。 因此，本发明的多肽可用于检测磷脂酰丝氨酸，此外还检测在细胞和肿瘤细胞表面上表达磷脂酰丝氨酸的凋亡细胞，并且还可用于凋亡细胞或肿瘤细胞的可视化。

公开(公告)号：US07374776B2

公开(公告)日：2008-05-20

申请号：US10528749

申请日：2002-09-30

申请人： In-San Kim ,  Byung Chae Cho

发明人： In-San Kim ,  Byung Chae Cho

IPC分类号： A61F2/00 ,  A61K33/42 ,  A61K33/00 ,  A61K33/10 ,  A61K33/06 ,  A61K47/00 ,  A01N59/26 ,  A01N59/24 ,  A01N59/06 ,  A01N25/00

CPC分类号： A61K33/06 ,  A61K33/10 ,  A61L27/446 ,  A61L2430/02 ,  A61K2300/00

摘要： The present invention relates to a composition for bone-filling, more particularly, to a bone-filling composition for stimulating bone-formation and bone consolidation comprising calcium sulfate and viscous biopolymers. The composition of the present invention can easily be administered into the missing part of injured bone. Since the composition of the present invention does not diffuse to surrounding organs, it can effectively be used for bone-filling material suitable for body.

摘要翻译： 本发明涉及一种用于骨填充的组合物，更具体地涉及一种用于刺激骨形成和骨固定的骨填充组合物，其包含硫酸钙和粘性生物聚合物。 本发明的组合物可以容易地施用于受损骨的缺损部分。 由于本发明的组合物不会扩散到周围的器官，所以可以有效地用于适合身体的骨填充材料。