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公开(公告)号:US08642537B2
公开(公告)日:2014-02-04
申请号:US12677639
申请日:2008-09-10
CPC分类号: C07K14/001 , A61K31/713 , A61K38/00 , A61K38/16 , A61K45/06 , C07K14/4702
摘要: The present invention provides non-naturally occurring polypeptides that specifically bind hepatitis B virus (HBV) DNA; and polynucleotides encoding the polypeptides. The present invention further provides methods of detecting HBV DNA; methods of detecting a covalently closed circular DNA (cccDNA) form of HBV; and methods for treating HBV infection.
摘要翻译: 本发明提供了特异性结合乙型肝炎病毒(HBV)DNA的非天然存在的多肽; 和编码多肽的多核苷酸。 本发明还提供检测HBV DNA的方法; 检测HBV共价闭合环状DNA(cccDNA)形式的方法; 以及治疗HBV感染的方法。
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公开(公告)号:USD497481S1
公开(公告)日:2004-10-26
申请号:US29195180
申请日:2003-12-08
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公开(公告)号:USD497482S1
公开(公告)日:2004-10-26
申请号:US29200230
申请日:2004-02-24
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公开(公告)号:USD491370S1
公开(公告)日:2004-06-15
申请号:US29191476
申请日:2003-10-08
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公开(公告)号:US20110015122A1
公开(公告)日:2011-01-20
申请号:US12677639
申请日:2008-09-10
CPC分类号: C07K14/001 , A61K31/713 , A61K38/00 , A61K38/16 , A61K45/06 , C07K14/4702
摘要: The present invention provides non-naturally occurring polypeptides that specifically bind hepatitis B virus (HBV) DNA; and polynucleotides encoding the polypeptides. The present invention further provides methods of detecting HBV DNA; methods of detecting a covalently closed circular DNA (cccDNA) form of HBV; and methods for treating HBV infection.
摘要翻译: 本发明提供了特异性结合乙型肝炎病毒(HBV)DNA的非天然存在的多肽; 和编码多肽的多核苷酸。 本发明还提供检测HBV DNA的方法; 检测HBV共价闭合环状DNA(cccDNA)形式的方法; 以及治疗HBV感染的方法。
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公开(公告)号:USD569626S1
公开(公告)日:2008-05-27
申请号:US29247636
申请日:2006-06-29
申请人: Michael A. Joyce , Lois Joyce , Janice Baehler
设计人: Michael A. Joyce , Lois Joyce , Janice Baehler
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公开(公告)号:USD569625S1
公开(公告)日:2008-05-27
申请号:US29215377
申请日:2004-10-18
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公开(公告)号:USD569624S1
公开(公告)日:2008-05-27
申请号:US29209941
申请日:2004-07-22
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公开(公告)号:US5222653A
公开(公告)日:1993-06-29
申请号:US842593
申请日:1992-02-28
申请人: Michael A. Joyce , William Thompson
发明人: Michael A. Joyce , William Thompson
摘要: In conventional track-can manufacture they are formed from symmetrical halves made (for example, by drop hammering) split along the longitudinal axis of the finished component. The conventional welding process required to complete the track-cans is then complicated due to the arcuate configuration of these components.According to the present invention track-cans are manufactured from a plurality of substantially tubular sections, for example a cap-end (39), a body portion (43) and a flange end (40). The components are made by deep drawing from a blank cut of suitable material. The components are welded together at their interface regions to form the track-can. The tubular construction of the components enables the process of peripheral welding which in turn is comparatively simple, and particularly amenable to robotic welding. The prior art welding process was considerably more complicated due to the arcuate configuration of track-cans.
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