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公开(公告)号:US20090092635A1
公开(公告)日:2009-04-09
申请号:US12192257
申请日:2008-08-15
申请人: David Kirkwood Clarke , Farooq Nasar , Rong Xu , Shakuntala Devi Megati , Michael Albin Egan , Amara Gbellu Luckay
发明人: David Kirkwood Clarke , Farooq Nasar , Rong Xu , Shakuntala Devi Megati , Michael Albin Egan , Amara Gbellu Luckay
IPC分类号: A61K39/12 , A61K39/165 , A61P37/04 , A61P31/12
CPC分类号: A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , C12N2740/16234 , C12N2760/18734 , C12N2760/18743 , C12N2760/20234 , C12N2760/20243 , Y02A50/412 , Y02A50/466
摘要: The present invention is directed to a method for generating an antigen-specific immune response in a subject in general and in particular to administering a priming dose of an immunogenic composition of a recombinant mumps virus (rMuV) that encodes an antigen followed by administering a boosting dose of recombinant vesicular stomatitis virus (rVSV) encoding an antigen.
摘要翻译: 本发明涉及在一般的受试者中产生抗原特异性免疫应答的方法,特别是给予起始剂量的编码抗原的重组腮腺炎病毒(rMuV)的免疫原性组合物,然后施用加强 剂量的编码抗原的重组水泡性口炎病毒(rVSV)。