公开(公告)号：US07232910B2

公开(公告)日：2007-06-19

申请号：US11264440

申请日：2005-10-31

申请人： Brigitte Leigh Ewanicki ,  Erik Jon Flahive ,  Annie Judith Kasparian ,  Mark Bryan Mitchell ,  Michael David Perry ,  Stacy Ann O'Neill-Slawecki ,  Neal William Sach ,  James Edward Saenz ,  Bing Shi ,  Nebojsa Slobodan Stankovic ,  Jayaram Kasturi Srirangam ,  Qingping Tian ,  Shu Yu

发明人： Brigitte Leigh Ewanicki ,  Erik Jon Flahive ,  Annie Judith Kasparian ,  Mark Bryan Mitchell ,  Michael David Perry ,  Stacy Ann O'Neill-Slawecki ,  Neal William Sach ,  James Edward Saenz ,  Bing Shi ,  Nebojsa Slobodan Stankovic ,  Jayaram Kasturi Srirangam ,  Qingping Tian ,  Shu Yu

IPC分类号： C07D401/12

CPC分类号： C07D401/06 ,  C07D231/56

摘要： The present invention relates to methods for preparing indazole compounds of formula I, which are useful as modulators and/or inhibitors of protein kinases. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula I.

摘要翻译： 本发明涉及制备式I的吲唑化合物的方法，其可用作蛋白激酶的调节剂和/或抑制剂。 本发明还涉及可用于制备式I化合物的中间体化合物。

公开(公告)号：US08808363B2

公开(公告)日：2014-08-19

申请号：US13573226

申请日：2012-08-31

申请人： Michael David Perry ,  Robert G. Matheny

发明人： Michael David Perry ,  Robert G. Matheny

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/848 ,  A61F2002/8483 ,  A61F2230/0095 ,  A61L27/3633 ,  A61L31/005

摘要： A vascular prosthesis comprising a tubular shaped expandable ECM member and at least one anchoring mechanism. In one embodiment, the anchoring mechanism comprises proximal and distal single or dual-ring anchors. In one embodiment, the anchoring mechanism comprises a multiple-ring anchor. The anchors preferably comprise a biodegradable metal, such as magnesium. The anchors can also comprise a shape memory alloy, such as nitinol, and a cross-linked ECM material. In some embodiments, the ECM member includes a pharmacological agent.

公开(公告)号：US20140067046A1

公开(公告)日：2014-03-06

申请号：US13573226

申请日：2012-08-31

申请人： Michael David Perry ,  Robert G. Matheny

发明人： Michael David Perry ,  Robert G. Matheny

IPC分类号： A61F2/82

CPC分类号： A61F2/07 ,  A61F2/848 ,  A61F2002/8483 ,  A61F2230/0095 ,  A61L27/3633 ,  A61L31/005

摘要： A vascular prosthesis comprising a tubular shaped expandable ECM member and at least one anchoring mechanism. In one embodiment, the anchoring mechanism comprises proximal and distal single or dual-ring anchors. In one embodiment, the anchoring mechanism comprises a multiple-ring anchor. The anchors preferably comprise a biodegradable metal, such as magnesium. The anchors can also comprise a shape memory alloy, such as nitinol, and a cross-linked ECM material. In some embodiments, the ECM member includes a pharmacological agent.

摘要翻译： 一种血管假体，其包括管状可扩张ECM构件和至少一个锚定机构。 在一个实施例中，锚固机构包括近端和远端单环或双环锚。 在一个实施例中，锚定机构包括多环锚固件。 锚固件优选包括可生物降解的金属，例如镁。 锚固件还可以包括形状记忆合金，例如镍钛诺和交联的ECM材料。 在一些实施方案中，ECM构件包括药理学试剂。

公开(公告)号：US20140239634A1

公开(公告)日：2014-08-28

申请号：US13773798

申请日：2013-02-22

申请人： Florent Michel ,  Raphael Michel ,  Danny Shen ,  Michael David Perry

发明人： Florent Michel ,  Raphael Michel ,  Danny Shen ,  Michael David Perry

IPC分类号： F16L25/10

CPC分类号： H04R1/1016 ,  A61M16/0672 ,  A61M25/04 ,  A61M2025/0226 ,  A61M2210/0618 ,  A61M2210/0662 ,  A61M2210/1042 ,  A61M2210/105 ,  H04R1/10 ,  H04R25/00 ,  H04R25/02

摘要： A securing mechanism comprising a plurality of outwardly projecting members having a plurality of contact points that are configured to contact a surface of an opening when disposed on a space access device that is inserted in the opening, the securing mechanism being configured to apply a pressure to a contact surface within the opening less than approximately 10000 kPa.

摘要翻译： 一种固定机构，包括多个向外突出的构件，其具有多个接触点，所述多个接触点构造成当设置在插入到所述开口中的空间进入装置上时接触开口的表面，所述固定机构构造成施加压力 开口内的接触面小于约10000kPa。

公开(公告)号：US07654082B2

公开(公告)日：2010-02-02

申请号：US11376891

申请日：2006-03-16

申请人： Michael David Perry ,  Duncan Bartlett Gilmore ,  Raymond Lindsay Hope ,  Gary James Campbell ,  Melissa Louise Kruger ,  Carmen Patricia Keating

发明人： Michael David Perry ,  Duncan Bartlett Gilmore ,  Raymond Lindsay Hope ,  Gary James Campbell ,  Melissa Louise Kruger ,  Carmen Patricia Keating

IPC分类号： F16D31/02

CPC分类号： F03B17/066 ,  F05B2240/97 ,  Y02E10/28 ,  Y02E10/38

摘要： An underwater power generation system (10) that has a line member (30) that moves along a defined pathway. A number of foils (40) drive the line member using the flow of a water current. The defined pathway lies in a plane that is substantially perpendicular to the flow of water current. A power take-off (114, 124) is connected to the line to produce power.

摘要翻译： 一种水下发电系统（10），其具有沿着限定的路径移动的线路构件（30）。 许多箔（40）使用水流的流动驱动线路构件。 所定义的通道位于基本上垂直于水流的平面中。 功率输出（114,124）连接到线路以产生电力。