METHODS AND KITS FOR DIAGNOSING NEURODEGENERATIVE DISEASE
    2.
    发明申请
    METHODS AND KITS FOR DIAGNOSING NEURODEGENERATIVE DISEASE 审中-公开
    用于诊断神经营养不良疾病的方法和工具

    公开(公告)号:US20110159527A1

    公开(公告)日:2011-06-30

    申请号:US12996604

    申请日:2009-06-15

    IPC分类号: G01N33/53 G01N33/68 C12Q1/02

    摘要: Methods and diagnostic kits for determining whether a subject may develop a or for diagnosing a neurodegenerative disease. The method includes quantitating the amount of alpha-synuclein and total protein in a cerebrospinal fluid (CSF) sample obtained from the subject and calculating a ratio of alpha-synuclein to total protein content; comparing the ratio of alpha-synuclein to total protein content in the CSF sample with the alpha-synuclein to total protein content ratio in CSF samples obtained from healthy neurodegenerative disease-free subjects; and (c) determining from the comparison whether the subject has a likelihood to develop neurodegenerative disease or making a diagnosis of neurodegenerative disease in a subject. A difference in the ratio of alpha-synuclein to total protein content indicates that the subject has a likelihood to develop a neurodegenerative disease or has developed a neurodegenerative disease.

    摘要翻译: 用于确定受试者是否可能开发或用于诊断神经变性疾病的方法和诊断试剂盒。 该方法包括定量从受试者获得的脑脊液(CSF)样品中α-突触核蛋白和总蛋白的量,并计算α-突触核蛋白与总蛋白含量的比例; 将来自健康神经退行性疾病的受试者的脑脊液样品中的α-突触核蛋白与α-共核蛋白的总蛋白含量与CSF样品中的总蛋白含量的比值与总蛋白含量比进行比较; 和(c)从比较中确定受试者是否可能发生神经变性疾病或对受试者进行神经变性疾病的诊断。 α-突触核蛋白与总蛋白质含量的比值之间的差异表明该受试者具有发展神经变性疾病或已经发展成神经变性疾病的可能性。