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    Oral Film Containing Opiate Enteric-Release Beads
    1.
    发明申请
    Oral Film Containing Opiate Enteric-Release Beads 有权
    口腔胶囊含鸦片肠球菌释放珠

    公开(公告)号：US20130273162A1

    公开(公告)日：2013-10-17

    申请号：US13445716

    申请日：2012-04-12

    申请人： Michael Hsin Chwen LI

    发明人： Michael Hsin Chwen LI

    IPC分类号： A61K9/00 ,  A61P19/02 ,  A61P25/30 ,  A61P25/06 ,  A61P25/00 ,  A61P15/00 ,  A61K31/485 ,  A61P19/04

    CPC分类号： A61K9/006 ,  A61K9/0056 ,  A61K9/1635 ,  A61K9/1652 ,  A61K31/485 ,  A61K45/06 ,  A61K47/32 ,  A61K47/38 ,  A61K2300/00

    摘要： A control release and abuse-resistant opiate drug delivery oral wafer or edible oral film dosage to treat pain and substance abuse is provided. The drug delivery oral wafer or edible oral film dosage includes a controlled release layer containing enteric-release beads dispersed in a polymer matrix. The enteric-release beads are formed from a therapeutic amount of an opioid agonist and/or pharmaceutically acceptable salt thereof and a sub-therapuetic amount of opioid antagonist and/or pharmaceutically acceptable salt thereof coated or encapsulated in an enteric-release polymer. The controlled release polymer matrix dissolves or disintegrates following administration or consumption of the oral wafer or edible oral film, releasing the enteric-release beads to be swallowed, with subsequent absorption of the active ingredients within the patient's intestines.

    摘要翻译： 提供了控制释放和滥用鸦片药物递送口服片或可食用的口服膜用于治疗疼痛和药物滥用。 药物递送口服片剂或可食用口服膜剂量包括含有分散在聚合物基质中的肠溶释放珠粒的控释层。 肠溶释放珠由治疗量的阿片样物质激动剂和/或其药学上可接受的盐和亚治疗量的阿片样物质拮抗剂和/或其药学上可接受的盐包被或包封在肠溶释放聚合物中形成。 控释聚合物基质在口服晶片或可食用口腔膜的施用或消耗后溶解或分解，释放要吞咽的肠溶释放珠粒，随后在患者肠内吸收活性成分。

    Oral film containing opiate enteric-release beads
    3.
    发明授权
    Oral film containing opiate enteric-release beads 有权

    公开(公告)号：US09687445B2

    公开(公告)日：2017-06-27

    申请号：US13445716

    申请日：2012-04-12

    申请人： Michael Hsin Chwen Li

    发明人： Michael Hsin Chwen Li

    IPC分类号： A61K9/00 ,  A61K47/38 ,  A61K47/32 ,  A61K31/485 ,  A61K45/06 ,  A61K9/16

    CPC分类号： A61K9/006 ,  A61K9/0056 ,  A61K9/1635 ,  A61K9/1652 ,  A61K31/485 ,  A61K45/06 ,  A61K47/32 ,  A61K47/38 ,  A61K2300/00

    摘要： A control release and abuse-resistant opiate drug delivery oral wafer or edible oral film dosage to treat pain and substance abuse is provided. The drug delivery oral wafer or edible oral film dosage includes a controlled release layer containing enteric-release beads dispersed in a polymer matrix. The enteric-release beads are formed from a therapeutic amount of an opioid agonist and/or pharmaceutically acceptable salt thereof and a sub-therapeutic amount of opioid antagonist and/or pharmaceutically acceptable salt thereof coated or encapsulated in an enteric-release polymer. The controlled release polymer matrix dissolves or disintegrates following administration or consumption of the oral wafer or edible oral film, releasing the enteric-release beads to be swallowed, with subsequent absorption of the active ingredients within the patient's intestines.

    Edible Oral Strip or Wafer Dosage Form Containing Ion Exchange Resin for Taste Masking
    5.
    发明申请
    Edible Oral Strip or Wafer Dosage Form Containing Ion Exchange Resin for Taste Masking 有权
    含有用于口味掩蔽的离子交换树脂的食用口服或晶片剂量形式

    公开(公告)号：US20140155483A1

    公开(公告)日：2014-06-05

    申请号：US14123490

    申请日：2012-05-30

    申请人： Michael Hsin Chwen Li ,  Markus Krumme

    发明人： Michael Hsin Chwen Li ,  Markus Krumme

    IPC分类号： A61K9/00 ,  A61K31/192 ,  B29C41/00 ,  A23L1/22

    CPC分类号： A61K36/47 ,  A23L27/88 ,  A23V2002/00 ,  A61K9/006 ,  A61K31/192 ,  A61K47/10 ,  A61K47/186 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/46 ,  B29B7/88 ,  B29B13/00 ,  B29B2013/005 ,  B29C39/02 ,  B29C39/36 ,  B29C39/38 ,  B29C41/003 ,  B29C69/001 ,  B29K2105/0035 ,  B29L2007/007

    摘要： An edible oral film strip dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.

    摘要翻译： 提供了含有不可食用的酸性活性药物成分，特别是酮洛芬，和作为主要掩味剂的离子交换树脂以及任选的碱性试剂，并进一步任选地含有一种或多种次级掩味剂的可食用的口服膜片剂型。 可食用的口服膜带剂量基质由至少一种水溶性或可混溶的聚合物形成。 任选的次要掩味成分包括一种或多种调味剂，甜味剂，冷却感觉剂和味觉受体阻断剂。 本发明的剂量最小化或完全掩盖与许多酸性活性药物成分相关的苦味，烧灼感和咽喉刺激。 公开了制备本发明可食用口服膜片剂型的方法，以及它们的给药方法。