公开(公告)号：US06489454B1

公开(公告)日：2002-12-03

申请号：US09096731

申请日：1998-06-11

申请人： Qiong Liu ,  Michael O. Hengartner ,  Thierry Andre Oliver Eddy Bogaert ,  Wim Maria Rene Van Criekinge

发明人： Qiong Liu ,  Michael O. Hengartner ,  Thierry Andre Oliver Eddy Bogaert ,  Wim Maria Rene Van Criekinge

IPC分类号： C07H2102

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  C07K14/43545 ,  C07K14/4702

摘要： The invention relates to a signal transduction pathway which promotes phagocytosis of apoptotic cells and in particular relates to a protein known as CED-6 in the nematode worm C. elegans, human equivalents of CED-6 protein and nucleic acids encoding them. The invention also relates to use of the proteins and encoding nucleic acids in assay methods for detecting compounds which enhance or inhibit the signal transduction pathway and use of the proteins, nucleic acids and identified enhancer or inhibitor compounds in methods of treatment of human or animal disease.

摘要翻译： 本发明涉及促进凋亡细胞吞噬作用的信号转导途径，特别涉及线虫蠕虫线虫中称为CED-6的蛋白质，CED-6蛋白质的人等价物和编码它们的核酸。 本发明还涉及蛋白质和编码核酸在测定方法中的用途，用于检测增强或抑制信号转导途径的化合物，以及在治疗人或动物疾病的方法中使用蛋白质，核酸和鉴定的增强子或抑制剂化合物 。