公开(公告)号：US11884532B2

公开(公告)日：2024-01-30

申请号：US17703715

申请日：2022-03-24

Applicant: Michael R. Braden

Inventor： Michael R. Braden

IPC: B67D3/00 ,  B65D81/20 ,  B67D99/00 ,  B65D1/02 ,  A61L2/18

CPC classification number: B67D3/0061 ,  B65D1/0223 ,  B65D81/2038 ,  B67D3/0093 ,  B67D99/00 ,  A61L2/186 ,  B67D3/0077

Abstract: A gravity flow liquid disinfectant dispensing reservoir comprised of a tapered base and a neck portion that extends centrally from the reservoir. An aperture located on the bottom of the reservoir facilitates the dispensing of liquid (i.e., disinfectant) from the reservoir into a holding tank. In another embodiment, a closed system for dispensing a liquid disinfectant into a tank containing liquid (effluent) and controlled via vacuum. The gravity flow device introduces disinfectant to the tank as the water level rises, giving the ultimate amount of contact time for treatment of effluent. Utilizing gravity and vacuum controlled dispensing of disinfectant dispenses disinfectant continuously and automatically in real time and provides for maximum contact time for minimal pathogen survival.

公开(公告)号：US20190276302A1

公开(公告)日：2019-09-12

申请号：US16299111

申请日：2019-03-11

Applicant: Michael R. Braden

Inventor： Michael R. Braden

IPC: B67D3/00 ,  B67D99/00 ,  B65D81/20

Abstract: A gravity flow liquid disinfectant dispensing reservoir comprised of a tapered base and a neck portion that extends centrally from the reservoir. An aperture located on the bottom of the reservoir facilitates the dispensing of liquid (i.e., disinfectant) from the reservoir into a holding tank. In another embodiment, a closed system for dispensing a liquid disinfectant into a tank containing liquid (effluent) and controlled via vacuum. The gravity flow device introduces disinfectant to the tank as the water level rises, giving the ultimate amount of contact time for treatment of effluent. Utilizing gravity and vacuum controlled dispensing of disinfectant dispenses disinfectant continuously in real time and provides for maximum contact time for minimal pathogen survival.

公开(公告)号：US07887784B2

公开(公告)日：2011-02-15

申请号：US12077898

申请日：2008-03-21

Applicant: John M. Gerdes ,  David B. Bolstad ,  Michael R. Braden ,  August W. Barany

Inventor： John M. Gerdes ,  David B. Bolstad ,  Michael R. Braden ,  August W. Barany

IPC: A61K51/04 ,  A61K31/497 ,  C07D401/04

CPC classification number: C07D401/04

Abstract: Racemic mixtures and enantiomerically pure forms of novel 1-[(2′-substituted)-piperazin-1′-yl]-isoquinolines are norepinephrine (NE) transporter (NET) inhibitor compounds. Compounds of the invention are considered therapeutic agents for central nervous system (CNS) diseases and disorders, without limitation, including neurodegeneration, anxiety, depression, attention deficit disorders, drug dependency, and post traumatic stress disorder. Examples of the chemical syntheses of the compounds of the invention are provided. The isoquinoline compounds of the invention competitively bind at NET at nanomolar concentrations. The isoquinoline agents of the invention bind selectively to NET over other competitive transporter targets and receptor binding sites, including those of serotonin and dopamine, amongst others. The chemical syntheses of the invention are suitable for labeling with radionuclide atoms. Radiolabeled forms of the novel 1-[(2′-substituted)-piperazin-1′-yl]-isoquinoline compounds are positron emission tomography and single photon emission tomography imaging tracers. Methods of in vivo imaging with the tracers within various subjects and tissues therein, including regions of the brain, are provided. Imaging methods with the tracers in combination other NET inhibitor agents are provided. The imaging methods within subjects allow quantitative detection of NET, determinations of NET distributions, and measures of tracer interactions at NET in the presence or absence of non-radioactive NET agents. The tracer imaging methods are suitable to locate, diagnose, identify, evaluate, detect or quantitate NET, or abnormalities of NET, or NE abnormalities; that are associated with various CNS diseases and disorders.

Abstract translation: 新颖的1 - [（2'-取代的） - 哌嗪-1'-基] - 异喹啉的外消旋混合物和对映体纯形式是去甲肾上腺素（NE）转运蛋白（NET）抑制剂化合物。 本发明的化合物被认为是中枢神经系统（CNS）疾病和病症的治疗剂，但不限于，包括神经变性，焦虑，抑郁，注意力缺陷障碍，药物依赖性和创伤后应激障碍。 提供了本发明化合物的化学合成的实例。 本发明的异喹啉化合物在NET下以纳摩尔浓度竞争结合。 本发明的异喹啉试剂与其它竞争性转运靶标和受体结合位点选择性结合，包括血清素和多巴胺等。 本发明的化学合成适用于用放射性核素原子标记。 新型1 - [（2'-取代） - 哌嗪-1'-基] - 异喹啉化合物的放射性标记形式为正电子发射断层扫描和单光子发射断层成像示踪剂。 提供了使用包括脑区域在内的各种受试者和组织内的示踪剂进行体内成像的方法。 提供与其他NET抑制剂组合的示踪剂的成像方法。 受试者中的成像方法允许NET的定量检测，NET分布的确定，以及在存在或不存在非放射性NET剂的情况下NET的示踪剂相互作用的测量。 示踪成像方法适用于定位，诊断，识别，评估，检测或定量NET，或NET异常或NE异常; 这与各种CNS疾病和疾病有关。

公开(公告)号：US20090184035A1

公开(公告)日：2009-07-23

申请号：US12413257

申请日：2009-03-27

Applicant: Michael R. Braden

Inventor： Michael R. Braden

IPC: C02F1/76

CPC classification number: C02F1/686 ,  C02F1/76

Abstract: A chlorinator for wastewater treatment systems having a clarifier tank connected by a fluid line to a pump tank, which includes a reservoir of disinfectant fluid and a dosage container communicating with the reservoir, and a siphon communicating with the fluid line and dosage contain to dispense a determined quantity of disinfectant to the pump tank after flow through the fluid line has dropped below the flow rate of a drain in the siphon. The dosage container is vented to atmosphere to prevent vacuum lock in operation and communicates with the reservoir at a flow rate substantially smaller than it communicates with the siphon. Flow through the fluid line induces priming of a siphon for subsequent distribution of the quantity of disinfectant fluid into the pump tank after flow through the fluid line has dropped below the flow rate of a drain in the siphon, at which time disinfectant is drawn from the dosage container. As the dosage container outgoing flow rate far exceeds the dosage container incoming flow rate, once the disinfectant level drops below the point of communication between the dosage container and the pump tank, no further disinfectant is drawn into the pump tank. A near-uniform volume of disinfectant fluid is thereby supplied.

Abstract translation: 一种用于废水处理系统的氯化器，其具有通过流体管线连接到泵罐的澄清池，所述净化罐包括消毒剂流体的储存器和与所述储存器连通的剂量容器，以及与所述流体管线连通的虹吸管和所述剂量包含以分配 通过流体管线流入泵罐后，确定的消毒剂量已经降低到虹吸管内排水口的流量。 将剂量容器排放到大气中以防止真空锁定在操作中并且以与其与虹吸管连通的流速基本上小的流速与储存器连通。 通过流体管线的流动引起虹吸管的引发，用于在通过流体管线的流动已经降低到虹吸管中的排水管的流速之前，随后将消耗剂流体量分配到泵罐中，此时将消毒剂从 剂量容器 由于剂量容器的流出速度远远超过剂量容器进入流量，一旦消毒剂水平下降到剂量容器和泵罐之间的连通点以下，则不会再将另外的消毒剂吸入泵罐。 由此提供近乎均匀的消毒液体积。

公开(公告)号：US20080267870A1

公开(公告)日：2008-10-30

申请号：US12077898

申请日：2008-03-21

Applicant: John M. Gerdes ,  David B. Bolstad ,  Michael R. Braden ,  August W. Barany

Inventor： John M. Gerdes ,  David B. Bolstad ,  Michael R. Braden ,  August W. Barany

IPC: C07D401/04 ,  A61K31/496 ,  A61P25/00 ,  A61K51/04 ,  G01T1/161

CPC classification number: C07D401/04

Abstract: Racemic mixtures and enantiomerically pure forms of novel 1-[(2′-substituted)-piperazin-1′-yl]-isoquinolines are norepinephrine (NE) transporter (NET) inhibitor compounds. Compounds of the invention are considered therapeutic agents for central nervous system (CNS) diseases and disorders, without limitation, including neurodegeneration, anxiety, depression, attention deficit disorders, drug dependency, and post traumatic stress disorder. Examples of the chemical syntheses of the compounds of the invention are provided. The isoquinoline compounds of the invention competitively bind at NET at nanomolar concentrations. The isoquinoline agents of the invention bind selectively to NET over other competitive transporter targets and receptor binding sites, including those of serotonin and dopamine, amongst others. The chemical syntheses of the invention are suitable for labeling with radionuclide atoms. Radiolabeled forms of the novel 1-[(2′-substituted)-piperazin-1′-yl]-isoquinoline compounds are positron emission tomography and single photon emission tomography imaging tracers. Methods of in vivo imaging with the tracers within various subjects and tissues therein, including regions of the brain, are provided. Imaging methods with the tracers in combination other NET inhibitor agents are provided. The imaging methods within subjects allow quantitative detection of NET, determinations of NET distributions, and measures of tracer interactions at NET in the presence or absence of non-radioactive NET agents. The tracer imaging methods are suitable to locate, diagnose, identify, evaluate, detect or quantitate NET, or abnormalities of NET, or NE abnormalities; that are associated with various CNS diseases and disorders.

Abstract translation: 新颖的1 - [（2'-取代的） - 哌嗪-1'-基] - 异喹啉的外消旋混合物和对映体纯形式是去甲肾上腺素（NE）转运蛋白（NET）抑制剂化合物。 本发明的化合物被认为是中枢神经系统（CNS）疾病和病症的治疗剂，但不限于，包括神经变性，焦虑，抑郁，注意力缺陷障碍，药物依赖性和创伤后应激障碍。 提供了本发明化合物的化学合成的实例。 本发明的异喹啉化合物在NET下以纳摩尔浓度竞争结合。 本发明的异喹啉试剂与其它竞争性转运靶标和受体结合位点选择性结合，包括血清素和多巴胺等。 本发明的化学合成适用于用放射性核素原子标记。 新型1 - [（2'-取代） - 哌嗪-1'-基] - 异喹啉化合物的放射性标记形式为正电子发射断层扫描和单光子发射断层成像示踪剂。 提供了使用包括脑区域在内的各种受试者和组织内的示踪剂进行体内成像的方法。 提供与其他NET抑制剂组合的示踪剂的成像方法。 受试者中的成像方法允许NET的定量检测，NET分布的确定，以及在存在或不存在非放射性NET剂的情况下NET的示踪剂相互作用的测量。 示踪成像方法适用于定位，诊断，识别，评估，检测或定量NET，或NET异常或NE异常; 这与各种CNS疾病和疾病有关。

公开(公告)号：US07651607B2

公开(公告)日：2010-01-26

申请号：US11684356

申请日：2007-03-09

Applicant: Michael R. Braden

Inventor： Michael R. Braden

IPC: C02F1/76 ,  G01F11/28

CPC classification number: C02F1/686 ,  C02F1/76

Abstract: A chlorinator for wastewater treatment systems having a circulation pump, circulation tank, and return flow line, which includes a reservoir of disinfectant fluid and a dosage container communicating with the reservoir and the circulation tank to dispense a determined quantity of disinfectant during operation of the circulation pump. The dosage container is vented to atmosphere to prevent vacuum lock in operation and communicates with the reservoir at a flow rate substantially smaller than it communicates with the circulation tank. Operation of the circulation pump causes flow through the return line, inducing distribution of the quantity of disinfectant fluid into the circulation tank. As the dosage container outgoing flow rate far exceeds the dosage container incoming flow rate, once the disinfectant level drops below the point of communication between the dosage container and the circulation tank, no her disinfectant is drawn into the circulation tank. A near-uniform volume of disinfectant fluid is thereby supplied per pump cycle.

Abstract translation: 具有循环泵，循环罐和回流管线的废水处理系统的氯化器，其包括消毒液储存器和与储存器和循环罐连通的剂量容器，以在循环操作期间分配确定量的消毒剂 泵。 将剂量容器排放到大气中以防止真空锁定在操作中并且以与流体槽连通的流速大的流量与储存器连通。 循环泵的运行导致通过返回管路的流动，导致消毒剂流体分配到循环罐中。 由于剂量容器的流出速度远远超过剂量容器进入流量，一旦消毒剂水平下降到剂量容器和循环罐之间的连通点以下，则没有将其消毒剂吸入循环罐。 因此每个泵循环提供近均匀体积的消毒液。

公开(公告)号：US20240337461A1

公开(公告)日：2024-10-10

申请号：US18131973

申请日：2023-04-07

Applicant: Michael R. Braden

Inventor： Michael R. Braden

IPC: F41B5/14 ,  D07B5/00

CPC classification number: F41B5/1411 ,  D07B5/00 ,  D07B2201/1048 ,  D07B2201/1068 ,  D07B2201/2024 ,  D07B2501/20 ,  F41B5/105

Abstract: A string such as a bowstring or cable used in archery bows and crossbows include multiple strands. The multiple strands are not bound to each other but remain parallel and positioned side-by-side. The desired number of strands are laid up to a determined length and grouped together to create a bundle. The bundles can have different properties such as strength and stability depending on the direction the strands and bundles are twisted.

公开(公告)号：US20160251242A1

公开(公告)日：2016-09-01

申请号：US15050083

申请日：2016-02-22

Applicant: Michael R. Braden

Inventor： Michael R. Braden

IPC: C02F1/68 ,  C02F1/50

CPC classification number: C02F1/686 ,  C02F1/50 ,  C02F1/76 ,  C02F2303/04 ,  G05D11/008

Abstract: A system for delivering disinfectant or other chemicals to effluent or water within a containment vessel, such as a wastewater storage tank. The invention includes a mounting bracket or housing; a rotor rotationally connected to the mounting bracket; a shaft connecting the rotor to the mounting bracket; a pump connected to the shaft, the pump having a casing and a rotor assembly; a container; and an tube having a first end within the container and a second end outside the container, a portion of the tube positioned within the pump and in contact with the rotor assembly.

Abstract translation: 将消毒剂或其他化学物质运送到泄放容器（如废水储罐）内的污水或水中的系统。 本发明包括安装支架或壳体; 旋转地连接到所述安装支架的转子; 将转子连接到安装支架的轴; 连接到所述轴的泵，所述泵具有壳体和转子组件; 一个容器 以及管，其具有在容器内的第一端和在容器外部的第二端，管的一部分位于泵内并与转子组件接触。

公开(公告)号：US20090134084A1

公开(公告)日：2009-05-28

申请号：US12364636

申请日：2009-02-03

Applicant: Michael R. Braden

Inventor： Michael R. Braden

IPC: C02F1/76

CPC classification number: C02F1/686 ,  C02F1/76

Abstract: A chlorinator for wastewater treatment systems having a circulation pump, circulation tank, and return flow line, which includes a reservoir of disinfectant fluid and a dosage container communicating with the reservoir, and a siphon communicating with the return flow line and dosage contain to dispense a determined quantity of disinfectant to the circulation tank after operation of the circulation pump. The dosage container is vented to atmosphere to prevent vacuum lock in operation and communicates with the reservoir at a flow rate substantially smaller than it communicates with the siphon. Operation of the circulation pump causes flow through the return line, inducing priming of a siphon for subsequent distribution of the quantity of disinfectant fluid into the circulation tank after operation of the circulation pump ceases, at which time disinfectant is drawn from the dosage container. As the dosage container outgoing flow rate far exceeds the dosage container incoming flow rate, once the disinfectant level drops below the point of communication between the dosage container and the circulation tank, no further disinfectant is drawn into the circulation tank. A near-uniform volume of disinfectant fluid is thereby supplied after each pump cycle.

Abstract translation: 一种具有循环泵，循环罐和回流管线的废水处理系统的氯化器，其包括消毒液的储存器和与储存器连通的剂量容器，以及与回流管线连通的虹吸管和剂量包含以分配 在循环泵运行后确定循环水箱的消毒剂量。 将剂量容器排放到大气中以防止真空锁定在操作中并且以与其与虹吸管连通的流速基本上小的流速与储存器连通。 循环泵的操作导致通过返回管路的流动，引起虹吸引发，以便在循环泵的操作停止之后将消毒剂流体量分配到循环罐中，此时从剂量容器中抽取消毒剂。 由于剂量容器的流出速度远远超过剂量容器进入流量，一旦消毒剂水平降低到剂量容器和循环罐之间的连通点以下，则不会再将进一步的消毒剂吸入循环罐。 因此在每个泵循环之后提供近乎均匀体积的消毒液。

公开(公告)号：US10011507B2

公开(公告)日：2018-07-03

申请号：US15050083

申请日：2016-02-22

Applicant: Michael R. Braden

Inventor： Michael R. Braden

IPC: C02F1/68 ,  C02F1/76 ,  G05D11/00 ,  C02F1/50

CPC classification number: C02F1/686 ,  C02F1/50 ,  C02F1/76 ,  C02F2303/04 ,  G05D11/008

Abstract: A system for delivering disinfectant or other chemicals to effluent or water within a containment vessel, such as a wastewater storage tank. The invention includes a mounting bracket or housing; a rotor rotationally connected to the mounting bracket; a shaft connecting the rotor to the mounting bracket; a pump connected to the shaft, the pump having a casing and a rotor assembly; a container; and an tube having a first end within the container and a second end outside the container, a portion of the tube positioned within the pump and in contact with the rotor assembly.