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1.发明申请3-CARBOXYPROPYL-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS 有权3-羧基丙氨酸氨基丁酸衍生物及相关化合物作为阿片受体拮抗剂公开(公告)号：US20140329845A1
公开(公告)日：2014-11-06
申请号：US14196186
申请日：2014-03-04
申请人： Sean G. Trapp , Michael R. Leadbetter , Daniel D. Long , Pierre-Jean Colson , Miroslav Rapta , Ying Yu
发明人： Sean G. Trapp , Michael R. Leadbetter , Daniel D. Long , Pierre-Jean Colson , Miroslav Rapta , Ying Yu
IPC分类号： C07C237/48 , A61K45/06 , A61K31/197
CPC分类号： C07C237/48 , A61K9/0075 , A61K9/2054 , A61K9/4858 , A61K31/197 , A61K31/485 , A61K45/06 , A61K47/02 , A61K47/12 , C07B2200/07 , C07C215/64 , C07C229/28 , C07C229/34 , C07C2601/14 , C07C2602/10 , Y10T436/173845
摘要： The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供式（I）的3-羧基丙基 - 氨基四氢化茚化合物：其中R1，R2，R3，R4，R5和R6在本说明书中定义，或其药学上可接受的盐，其为μ阿片受体 。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与阿片样物质受体活性相关的病症的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US08497287B2
公开(公告)日：2013-07-30
申请号：US13653652
申请日：2012-10-17
CPC分类号： C07C237/48 , A61K9/0019 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K9/4866 , A61K47/12 , A61K47/14 , A61K47/26 , C07C229/28 , C07C229/34 , C07C237/06 , C07C237/14 , C07C237/20 , C07C2601/14 , C07C2602/10 , C07D295/185
摘要： The invention provides aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, n, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供式（I）的氨基四氢化萘化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，n和m在本说明书中定义，或其药学上可接受的盐， 阿片受体。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与阿片样物质受体活性相关的病症的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US08314128B2
公开(公告)日：2012-11-20
申请号：US13330369
申请日：2011-12-19
CPC分类号： C07C237/48 , A61K9/0019 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K9/4866 , A61K47/12 , A61K47/14 , A61K47/26 , C07C229/28 , C07C229/34 , C07C237/06 , C07C237/14 , C07C237/20 , C07C2601/14 , C07C2602/10 , C07D295/185
摘要： The invention provides aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, n, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供式（I）的氨基四氢化萘化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，n和m在本说明书中定义，或其药学上可接受的盐， 阿片受体。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与阿片样物质受体活性相关的病症的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20120283195A1
公开(公告)日：2012-11-08
申请号：US13328284
申请日：2011-12-16
CPC分类号： C07K9/008 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/02 , A61K9/19 , A61K9/2018 , A61K9/4858 , A61K38/14 , A61K47/06 , A61K47/12 , A61K47/26 , A61K47/40 , A61K47/6951 , B82Y5/00
摘要： Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译： 公开了被一个或多个各自包含一个或多个膦酰基的取代基取代的糖肽; 和含有这些糖肽衍生物的药物组合物。 所公开的糖肽衍生物可用作抗菌剂。
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公开(公告)号：US07700550B2
公开(公告)日：2010-04-20
申请号：US11977429
申请日：2007-10-24
IPC分类号： A61K38/14
CPC分类号： C07K9/008 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/02 , A61K9/19 , A61K9/2018 , A61K9/4858 , A61K38/14 , A61K47/06 , A61K47/12 , A61K47/26 , A61K47/40 , A61K47/6951 , B82Y5/00
摘要： Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译： 公开了被一个或多个各自包含一个或多个膦酰基的取代基取代的糖肽; 和含有这些糖肽衍生物的药物组合物。 所公开的糖肽衍生物可用作抗菌剂。
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公开(公告)号：US07405199B2
公开(公告)日：2008-07-29
申请号：US11233220
申请日：2005-09-22
IPC分类号： A61K38/16
CPC分类号： C07K9/008 , A61K38/00 , Y02A50/473
摘要： This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
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7.发明授权公开(公告)号：US06962970B2
公开(公告)日：2005-11-08
申请号：US10092088
申请日：2002-03-06
申请人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
发明人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
IPC分类号： A61K38/00 , A61K20060101 , A61K38/14 , A61P31/04 , C07K20060101 , C07K7/06 , C07K9/00 , C07K7/50
摘要： Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译： 公开了具有至少一个下式的取代基的糖肽化合物的衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”？> - R < （Z） <？in-line-formula description =“In-line Formulas”end =“tail”？>其中R a
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公开(公告)号：US5226944A
公开(公告)日：1993-07-13
申请号：US959850
申请日：1992-10-13
CPC分类号： A01N57/30 , A01N57/28 , C07F9/4465
摘要： Compounds having the formula ##STR1## in which: R is C.sub.1 -C.sub.8 alkyl; or phenyl optionally substituted by 1 or 2 groups selected from C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, nitro or halo;R.sub.1 is C.sub.1 -C.sub.4 alkyl or phenyl;R.sub.2 is C.sub.1 -C.sub.4 alkyl;R.sub.3 is C.sub.2 -C.sub.4 alkyl or allyl; andX is oxygen, sulfur or NR.sub.4 where R.sub.4 is hydrogen or C.sub.3 -C.sub.4 alkyl;provided that(i) if R.sub.1 is methyl, R is phenyl or substituted phenyl and(ii) if R.sub.3 is isopropyl, X is NR.sub.4, and R.sub.1 is alkyl; and their agriculturally acceptable salts are herbicides.
摘要翻译： 具有式“IMAGE”的化合物，其中：R是C 1 -C 8烷基; 或任选被1或2个选自C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷氧基，硝基或卤素的基团取代的苯基; R1是C1-C4烷基或苯基; R2是C1-C4烷基; R3是C2-C4烷基或烯丙基; X是氧，硫或NR 4，其中R 4是氢或C 3 -C 4烷基; 条件是（i）如果R1是甲基，R是苯基或取代的苯基，和（ii）如果R3是异丙基，则X是NR4，R1是烷基; 其农业上可接受的盐是除草剂。
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公开(公告)号：US08541375B2
公开(公告)日：2013-09-24
申请号：US13328284
申请日：2011-12-16
CPC分类号： C07K9/008 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/02 , A61K9/19 , A61K9/2018 , A61K9/4858 , A61K38/14 , A61K47/06 , A61K47/12 , A61K47/26 , A61K47/40 , A61K47/6951 , B82Y5/00
摘要： Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
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10.发明授权公开(公告)号：US08492399B2
公开(公告)日：2013-07-23
申请号：US13652808
申请日：2012-10-16
IPC分类号： A01N43/42
CPC分类号： C07C237/48 , A61K9/0075 , A61K9/2054 , A61K9/4858 , A61K31/197 , A61K31/485 , A61K45/06 , A61K47/02 , A61K47/12 , C07B2200/07 , C07C215/64 , C07C229/28 , C07C229/34 , C07C2601/14 , C07C2602/10 , Y10T436/173845
摘要： The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
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