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    Ligands for imaging cardiac innervation
    3.
    发明授权
    Ligands for imaging cardiac innervation 有权
    用于成像心脏神经支配的配体

    公开(公告)号：US08491868B2

    公开(公告)日：2013-07-23

    申请号：US12448575

    申请日：2007-12-21

    Applicant: Ajay Purohit ,  Thomas D. Harris ,  Heike S. Radeke ,  Simon P. Robinson ,  Ming Yu ,  David S. Casebier ,  Michael T. Azure

    Inventor： Ajay Purohit ,  Thomas D. Harris ,  Heike S. Radeke ,  Simon P. Robinson ,  Ming Yu ,  David S. Casebier ,  Michael T. Azure

    IPC: A61K51/00 ,  A61K51/04 ,  C07C279/06 ,  A01N47/44

    CPC classification number: A61K51/04 ,  A61K51/0453 ,  A61K51/0459 ,  C07B59/001 ,  C07B2200/05 ,  C07C215/60 ,  C07C217/70 ,  C07C279/06 ,  C07C279/08

    Abstract: Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.

    Abstract translation: 公开了用于心脏神经支配成像的核医学应用（PET成像）中用作成像剂的新型化合物。 这些基于PET的放射性示踪剂可能表现出增加的稳定性，减少NE释放（从而减少副作用），改进的定量数据，和/或对先前的放射性示踪剂对VMAT的高亲和力。 还提供了使用化合物成像心脏神经支配的方法。 在某些情况下，化合物通过在各种位置上衍生化某些化合物而形成：芳基，烷基，酮基，苄基，β-烷基醚，γ-丙基烷基醚和β-丙基烷基醚。 或者或另外，将甲基a加入到胺中，和/或儿茶酚官能团被消除或掩蔽，作为使这些化合物更稳定的方式。

    LIGANDS FOR IMAGING CARDIAC INNERVATION
    10.
    发明申请
    LIGANDS FOR IMAGING CARDIAC INNERVATION 有权
    用于成像心脏感染的配对

    公开(公告)号：US20100221182A1

    公开(公告)日：2010-09-02

    申请号：US12448575

    申请日：2007-12-21

    Applicant: Ajay Purohit ,  Thomas D, Harris ,  Heike S. Radeke ,  Simon P. Robinson ,  Ming Yu ,  David S. Casebier ,  Michael T. Azure

    Inventor： Ajay Purohit ,  Thomas D, Harris ,  Heike S. Radeke ,  Simon P. Robinson ,  Ming Yu ,  David S. Casebier ,  Michael T. Azure

    IPC: A61K51/04 ,  C07D233/88 ,  C07C279/08 ,  C07C215/30 ,  C07D295/14

    CPC classification number: A61K51/04 ,  A61K51/0453 ,  A61K51/0459 ,  C07B59/001 ,  C07B2200/05 ,  C07C215/60 ,  C07C217/70 ,  C07C279/06 ,  C07C279/08

    Abstract: Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.

    Abstract translation: 公开了用于心脏神经支配成像的核医学应用（PET成像）中用作成像剂的新型化合物。 这些基于PET的放射性示踪剂可能表现出增加的稳定性，减少NE释放（从而减少副作用），改进的定量数据，和/或对先前的放射性示踪剂对VMAT的高亲和力。 还提供了使用化合物成像心脏神经支配的方法。 在某些情况下，化合物通过在各种位置上衍生化某些化合物而形成：芳基，烷基，酮基，苄基，β-烷基醚，γ-丙基烷基醚和β-丙基烷基醚。 或者或另外，将甲基a加入到胺中，和/或儿茶酚官能团被消除或掩蔽，作为使这些化合物更稳定的方式。

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