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公开(公告)号：US08309307B2
公开(公告)日：2012-11-13
申请号：US13286975
申请日：2011-11-01
CPC分类号： C12Q1/6841
摘要： The present invention generally relates to spatial and structural genomic analysis compositions, which can be used for the mapping of chromosomes and structural analyses of chromosomal rearrangements, including the entire chromosome, as well as specific portions or regions of interest of the chromosomes. In some embodiments, multiple portions of the genome can be distinguished, for instance, using a first detection entity and a second detection entity different from the first detection entity. The detection entities may be immobilized relative to oligonucleotides, which may be selected to bind to different locations within the chromosome. For instance, the oligonucleotides may be at least substantially complementary to the chromosome, e.g., substantially complementary to a specific location of the chromosome.
摘要翻译： 本发明一般涉及空间和结构基因组分析组合物，其可以用于染色体的定位和染色体重排的结构分析，包括整个染色体以及染色体感兴趣的具体部分或区域。 在一些实施例中，可以区分基因组的多个部分，例如使用不同于第一检测实体的第一检测实体和第二检测实体。 检测实体可以相对于寡核苷酸被固定，寡核苷酸可被选择以结合染色体内的不同位置。 例如，寡核苷酸可以至少基本上与染色体互补，例如与染色体的特定位置基本互补。
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公开(公告)号：US20120053082A1
公开(公告)日：2012-03-01
申请号：US13286975
申请日：2011-11-01
CPC分类号： C12Q1/6841
摘要： The present invention generally relates to spatial and structural genomic analysis compositions, which can be used for the mapping of chromosomes and structural analyses of chromosomal rearrangements, including the entire chromosome, as well as specific portions or regions of interest of the chromosomes. In some embodiments, multiple portions of the genome can be distinguished, for instance, using a first detection entity and a second detection entity different from the first detection entity. The detection entities may be immobilized relative to oligonucleotides, which may be selected to bind to different locations within the chromosome. For instance, the oligonucleotides may be at least substantially complementary to the chromosome, e.g., substantially complementary to a specific location of the chromosome.
摘要翻译： 本发明一般涉及空间和结构基因组分析组合物，其可以用于染色体的定位和染色体重排的结构分析，包括整个染色体以及染色体感兴趣的具体部分或区域。 在一些实施例中，可以区分基因组的多个部分，例如使用不同于第一检测实体的第一检测实体和第二检测实体。 检测实体可以相对于寡核苷酸被固定，寡核苷酸可被选择以结合染色体内的不同位置。 例如，寡核苷酸可以至少基本上与染色体互补，例如与染色体的特定位置基本互补。
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公开(公告)号：US20070238104A1
公开(公告)日：2007-10-11
申请号：US11400475
申请日：2006-04-07
CPC分类号： C12Q1/6816 , C12Q2525/186
摘要： The present invention generally relates to competitive oligonucleotides and, in some embodiments, to competitive oligonucleotides for use in comparative genomic hybridization (CGH) and related techniques. One aspect is generally directed to a blocking composition constructed and arranged to be used in an assay of a nucleic acid. The blocking composition may comprise oligonucleotides comprising sequences selected to hybridize to the nucleic acid used in the assay. Another aspect is generally directed to performing CGH assays and similar techniques on genomic DNA, in the absence of a Cot-1 fraction, such that the genomic DNA does not substantially cross-hybridize. Yet other aspects of the invention are directed to devices or kits for making or using competitive oligonucleotides, methods of promoting such competitive oligonucleotides, or the like.
摘要翻译： 本发明一般涉及竞争性寡核苷酸，在一些实施方案中涉及用于比较基因组杂交（CGH）和相关技术的竞争性寡核苷酸。 一个方面通常涉及构建和排列用于核酸测定中的阻断组合物。 封闭组合物可以包含寡核苷酸，其包含选择用于与测定中使用的核酸杂交的序列。 另一方面通常涉及在不存在Cot-1级分的情况下对基因组DNA进行CGH测定和类似技术，使得基因组DNA基本上不交叉杂交。 本发明的其它方面涉及用于制备或使用竞争性寡核苷酸的装置或试剂盒，促进这种竞争性寡核苷酸的方法等。
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公开(公告)号：US08058055B2
公开(公告)日：2011-11-15
申请号：US11400481
申请日：2006-04-07
CPC分类号： C12Q1/6841
摘要： The present invention generally relates to spatial and structural genomic analysis compositions, which can be used for the mapping of chromosomes and structural analyses of chromosomal rearrangements, including the entire chromosome, as well as specific portions or regions of interest of the chromosomes. In some embodiments, multiple portions of the genome can be distinguished, for instance, using a first detection entity and a second detection entity different from the first detection entity. The detection entities may be immobilized relative to oligonucleotides, which may be selected to bind to different locations within the chromosome. For instance, the oligonucleotides may be at least substantially complementary to the chromosome, e.g., substantially complementary to a specific location of the chromosome.
摘要翻译： 本发明一般涉及空间和结构基因组分析组合物，其可以用于染色体的定位和染色体重排的结构分析，包括整个染色体以及染色体感兴趣的具体部分或区域。 在一些实施例中，可以区分基因组的多个部分，例如使用不同于第一检测实体的第一检测实体和第二检测实体。 检测实体可以相对于寡核苷酸被固定，寡核苷酸可被选择以结合染色体内的不同位置。 例如，寡核苷酸可以至少基本上与染色体互补，例如与染色体的特定位置基本互补。
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公开(公告)号：US20090118137A1
公开(公告)日：2009-05-07
申请号：US12351720
申请日：2009-01-09
IPC分类号： C40B30/04
CPC分类号： C12Q1/6816 , C12Q2525/186
摘要： The present invention generally relates to competitive oligonucleotides and, in some embodiments, to competitive oligonucleotides for use in comparative genomic hybridization (CGH) and related techniques. One aspect is generally directed to a blocking composition constructed and arranged to be used in an assay of a nucleic acid. The blocking composition may comprise oligonucleotides comprising sequences selected to hybridize to the nucleic acid used in the assay. Another aspect is generally directed to performing CGH assays and similar techniques on genomic DNA, in the absence of a Cot-1 fraction, such that the genomic DNA does not substantially cross-hybridize. Yet other aspects of the invention are directed to devices or kits for making or using competitive oligonucleotides, methods of promoting such competitive oligonucleotides, or the like.
摘要翻译： 本发明一般涉及竞争性寡核苷酸，在一些实施方案中涉及用于比较基因组杂交（CGH）和相关技术的竞争性寡核苷酸。 一个方面通常涉及构建和排列用于核酸测定中的阻断组合物。 封闭组合物可以包含寡核苷酸，其包含选择用于与测定中使用的核酸杂交的序列。 另一方面通常涉及在不存在Cot-1级分的情况下对基因组DNA进行CGH测定和类似技术，使得基因组DNA基本上不交叉杂交。 本发明的其它方面涉及用于制备或使用竞争性寡核苷酸的装置或试剂盒，促进这种竞争性寡核苷酸的方法等。
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