公开(公告)号：US6143866A

公开(公告)日：2000-11-07

申请号：US375242

申请日：1995-01-19

申请人： Michael T. Brewer ,  Karin K. Hale ,  Michael W. King ,  Tadahiko Kohno ,  Charles Squires ,  Robert C. Thompson ,  Rebecca W. Vanderslice ,  James Vannice

发明人： Michael T. Brewer ,  Karin K. Hale ,  Michael W. King ,  Tadahiko Kohno ,  Charles Squires ,  Robert C. Thompson ,  Rebecca W. Vanderslice ,  James Vannice

IPC分类号： A61K38/00 ,  C07K14/715 ,  C12N15/12 ,  C07K14/705 ,  C12N1/00

CPC分类号： C07K14/7151 ,  A61K38/00 ,  Y10S930/14

摘要： At least two substantially purified tumor necrosis factor (TNF) inhibitors are disclosed which are glycoproteins that are active against TNF. The isolation of 3O kDa and 40 KDa TNF inhibitor from urine is disclosed. The deglycosylated form of the 3O kDa TNF inhibitor and 40 kDa TNF inhibitor are described as being active against TNF. The 40 kDa TNF inhibitor is active against both TNF alpha a TNF beta. The amino acid sequence of the 30 kDa TNF inhibitor and the 40 kDa TNF inhibitor are disclosed. Methods for isolating the TNF inhibitors from human U937 cell medium and producing the proteins by recombinant-DNA methods are also described.

摘要翻译： 公开了至少两种基本上纯化的肿瘤坏死因子（TNF）抑制剂，其是对TNF具有活性的糖蛋白。 公开了从尿液中分离出30kDa和40KDa的TNF抑制剂。 描述了30kDa TNF抑制剂和40kDa TNF抑制剂的脱糖基化形式对TNF具有活性。 40kDa的TNF抑制剂对TNFα和TNFβ均有活性。 公开了30kDa TNF抑制剂和40kDa TNF抑制剂的氨基酸序列。 还描述了通过重组DNA方法从人U937细胞培养基中分离TNF抑制剂并产生蛋白质的方法。

公开(公告)号：US20090207041A1

公开(公告)日：2009-08-20

申请号：US12388995

申请日：2009-02-19

申请人： Ralf Zaeper ,  Michael W. King

发明人： Ralf Zaeper ,  Michael W. King

IPC分类号： G01V3/00

CPC分类号： G01V11/002 ,  E21B47/122

摘要： A method of measuring while drilling includes positioning at least one sensor downhole; and transmitting sensed data while drilling from the at least one sensor to surface without storing the sensed data downhole and system.

摘要翻译： 在钻井时测量的方法包括将至少一个传感器定位在井下; 以及在从所述至少一个传感器到表面的钻孔期间传送感测数据，而不将所述感测数据存储在井下和系统中。