公开(公告)号：US20090117593A1

公开(公告)日：2009-05-07

申请号：US11982371

申请日：2007-11-01

申请人： Marina Chuenkova ,  Miercio Pereira Perrin

发明人： Marina Chuenkova ,  Miercio Pereira Perrin

IPC分类号： C07K14/435 ,  C07K1/00 ,  C12N5/06 ,  G01N33/554

CPC分类号： G01N33/74 ,  C07K14/44 ,  G01N2333/71 ,  G01N2500/10

摘要： The invention relates to T. cruzi trans-sialidase (TS) and to the neurotrophic and IL-6 secretion-inducing activities of the protein. TS, neurotrophic variants and/or neurotrophic peptides based upon the sequence of TS can be administered to a mammal to directly or indirectly provide neurotrophic support for neurons. A mammalian neurotrophic factor (e.g., CNTF, LIF) can be co-administered with the TS, neurotrophic variant and/or neurotrophic peptide. TS, IL-6 secretion-inducing variants and/or IL-6 secretion-inducing peptides based upon the sequence of TS can be administered to a mammal to induce the secretion of IL-6. TS, active variants and/or active peptides can be administered to a mammal having an acquired or congenital condition characterized by neuronal degeneration or to a mammal that has experienced trauma to the brain, spinal cord or peripheral nerves. The invention also relates to neurotrophic and IL-6 secretion-inducing variants of TS and to neurotrophic and IL-6 secretion-inducing peptides. The invention also relates to compositions comprising TS, active variants thereof and/or active peptides and a physiologically acceptable carrier.

摘要翻译： 本发明涉及克氏锥虫唾液酸酶（TS）和蛋白质的神经营养和IL-6分泌诱导活性。 可以将基于TS序列的TS，神经营养变体和/或神经营养肽施用于哺乳动物以直接或间接地为神经元提供神经营养支持。 哺乳动物神经营养因子（例如，CNTF，LIF）可以与TS，神经营养变体和/或神经营养肽共同施用。 基于TS序列的TS，IL-6分泌诱导变体和/或IL-6分泌诱导肽可以给予哺乳动物以诱导IL-6的分泌。 TS，活性变体和/或活性肽可以被给予具有以神经元变性为特征的获得性或先天性病症的哺乳动物或经历对脑，脊髓或周围神经的创伤的哺乳动物。 本发明还涉及TS的神经营养和IL-6分泌诱导变体，以及神经营养和IL-6分泌诱导肽。 本发明还涉及包含TS，其活性变体和/或活性肽和生理上可接受的载体的组合物。