公开(公告)号：US4371514A

公开(公告)日：1983-02-01

申请号：US166519

申请日：1980-07-07

申请人： Toshiharu Nagatsu ,  Takeshi Kato ,  Tokio Yamaguchi ,  Miki Akino ,  Sadao Matsuura ,  Takashi Sugimoto

发明人： Toshiharu Nagatsu ,  Takeshi Kato ,  Tokio Yamaguchi ,  Miki Akino ,  Sadao Matsuura ,  Takashi Sugimoto

IPC分类号： C07D239/48 ,  C07D475/02 ,  C07D475/04 ,  G01N33/534 ,  G01N33/82 ,  G01N33/56 ,  C07D475/00 ,  G01N33/58

CPC分类号： C07D239/48 ,  C07D475/02 ,  C07D475/04 ,  G01N33/534 ,  G01N33/82

摘要： Pterin derivatives are described having the formula (I) ##STR1## wherein R represents a hydroxyphenyl group, a radioiodinated hydroxyphenyl group, a tyraminocarbonyl group, a radioiodinated tyraminocarbonyl group, a proteinocarbonyl group or a carboxy group; Q represents a straight or branched chain alkylene group having 1 to 6 carbon atoms; and R.sub.6 and R.sub.7 each represents a hydrogen, an alkyl group having from 1 to 6 carbon atoms, a hydroxyalkyl group having from 1 to 6 carbon atoms; and a radioimmunoassay method is described using a radioiodinated 4-hydroxy-2-tyraminopteridine derivative or a radioiodinated 4-hydroxy-2-tyraminocarbonylalkylaminopteridine derivative as the tracer.

摘要翻译： 描述了具有式（I）的蝶呤衍生物：其中R表示羟基苯基，放射性碘化羟基苯基，酪氨酸羰基，放射性碘化的酪氨酸羰基，蛋白质羰基或羧基; Q表示碳原子数1〜6的直链或支链亚烷基。 并且R 6和R 7各自表示氢，具有1至6个碳原子的烷基，具有1至6个碳原子的羟烷基; 并且使用放射性碘化的4-羟基-2-酪氨酸脒衍生物或放射性碘化的4-羟基-2-酪氨酸羰基烷基氨基脒衍生物作为示踪剂来描述放射免疫测定方法。