公开(公告)号：US07052917B1

公开(公告)日：2006-05-30

申请号：US10048230

申请日：2000-07-28

申请人： Noriyuki Ohnishi ,  Mikiko Yoshida ,  Kazunori Kataoka ,  Katsuhiko Ueno

发明人： Noriyuki Ohnishi ,  Mikiko Yoshida ,  Kazunori Kataoka ,  Katsuhiko Ueno

IPC分类号： G01N33/545 ,  C07K17/08

CPC分类号： C07D495/04 ,  C08F20/38 ,  C08F246/00

摘要： The present invention is to prepare a novel polymerizable biotin derivative represented by formula (I) shown below and make it possible to synthesize or design a polyfunctional or multifunctional polymer using the derivative. In formula (I), R2 represents a hydrogen atom or an alkyl group, R3 and R4 each independently represents a hydrogen atom, an alkyl group or an aryl group, T represents an oxygen atom or ═NH, W represents a single bond, a carbonyl group, a thiocarbonyl group or a C1-5 alkylene group, U represents a single bond or —NH—, X represents a single bond, a C1-8 hydrocarbon bond, an oxygen atom or —NH—, Y represents a single bond, a carbonyl group, a thiocarbonyl group, —NH—, a 1,2-dioxyethylene group or a 1,2-diaminoethylene group, Z represents a single bond, a carbonyl group, a thiocarbonyl group, a C1-5 alkylene group, an oxygen atom or —NH—, and V represents a single bond or a C1-5 alkylene group.

摘要翻译： 本发明是为了制备由下述式（I）表示的新型可聚合生物素衍生物，并且可以使用该衍生物合成或设计多官能或多官能聚合物。 在式（I）中，R 2表示氢原子或烷基，R 3和R 4各自独立地表示氢原子， 烷基或芳基，T表示氧原子或-NH，W表示单键，羰基，硫代羰基或C 1-5亚烷基，U表示单 键或-NH-，X表示单键，C 1-8烃键，氧原子或-NH-，Y表示单键，羰基，硫代羰基， NH-，1,2-二氧乙烯基或1,2-二氨基亚乙基，Z表示单键，羰基，硫代羰基，C 1-5 - 亚烷基，氧 原子或-NH-，V表示单键或C 1-5 - 亚烷基。