公开(公告)号：US6146859A

公开(公告)日：2000-11-14

申请号：US384667

申请日：1999-08-27

Applicant: Shui-Tein Chen ,  Min-Jen Tseng ,  Boonyaras Sookkheo

Inventor： Shui-Tein Chen ,  Min-Jen Tseng ,  Boonyaras Sookkheo

IPC: C12P13/22 ,  C12P13/04

CPC classification number: C12P13/22

Abstract: A process for producing L-homophenylalanine comprises the step of reacting 2-oxo-4-phenylbutyric acid with a L-amino acid in the presence of tyrosine aminotransferase in a reaction solution to produce L-homophenylalanine.

Abstract translation: 制备L-高苯丙氨酸的方法包括在反应溶液中在酪氨酸氨基转移酶存在下使2-氧代-4-苯基丁酸与L-氨基酸反应以产生L-高苯丙氨酸的步骤。

公开(公告)号：US20120231016A1

公开(公告)日：2012-09-13

申请号：US13406209

申请日：2012-02-27

Applicant: Min-Jen Tseng ,  Ching-Wu Hsia ,  Ko-Ta Cheng ,  Chun-Mao Lin

Inventor： Min-Jen Tseng ,  Ching-Wu Hsia ,  Ko-Ta Cheng ,  Chun-Mao Lin

IPC: A61K39/395 ,  A61P17/14

CPC classification number: C07K16/18 ,  A61K39/00

Abstract: The present invention discloses a pharmaceutical composition for inhibiting histone H4 and a manufacturing method thereof. The pharmaceutical composition comprises an anti-histone H4 antibody and a pharmaceutically acceptable excipient. The hair loss resulted from medications, including cancer drugs, can be reduced by using the pharmaceutical composition of the present invention, thereby resolving mental depression and promoting prognosis effects for patients.

Abstract translation: 本发明公开了一种抑制组蛋白H4的药物组合物及其制造方法。 药物组合物包含抗组蛋白H4抗体和药学上可接受的赋形剂。 通过使用本发明的药物组合物可以减少包括癌症药物在内的药物引起的脱发，从而解决精神抑郁并促进患者的预后效果。