公开(公告)号：US09498609B2

公开(公告)日：2016-11-22

申请号：US12893477

申请日：2010-09-29

申请人： Frank Tagliaferri ,  Alan Smith ,  David Enscore ,  Gaurav Tolia ,  Mirek Baudys

发明人： Frank Tagliaferri ,  Alan Smith ,  David Enscore ,  Gaurav Tolia ,  Mirek Baudys

IPC分类号： A61M37/00 ,  A61K9/70 ,  A61K31/4468 ,  A61K31/485 ,  A61K47/12 ,  A61K47/18 ,  A61K47/38

CPC分类号： A61M37/00 ,  A61K9/7053 ,  A61K31/4468 ,  A61K31/485 ,  A61K47/12 ,  A61K47/183 ,  A61K47/38 ,  A61P5/50 ,  A61P23/02

摘要： Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.

摘要翻译： 公开了一种用于通过穿过受试者的生物膜的至少一个形成的途径将渗透组合物递送至受试者的贴剂，系统和方法。 所述贴剂包含基质，至少一个亲水性渗透物，其设置在所述基质内，其中所述渗透剂的至少一部分可以溶解在从所述受试者接收的生物水分中，以及至少一种渗透性增强剂。 还公开了用于通过穿过受试者的皮肤层的至少一个形成的途径将渗透组合物递送至受试者的系统和方法。

公开(公告)号：US20190117947A1

公开(公告)日：2019-04-25

申请号：US15632329

申请日：2017-06-24

申请人： Frank Tagliaferri ,  Alan Smith ,  David Enscore ,  Gaurav Tolia ,  Mirek Baudys

发明人： Frank Tagliaferri ,  Alan Smith ,  David Enscore ,  Gaurav Tolia ,  Mirek Baudys

IPC分类号： A61M37/00 ,  A61K47/38 ,  A61K47/18 ,  A61K47/12 ,  A61P5/50 ,  A61K31/4468 ,  A61K9/70 ,  A61P23/02 ,  A61K31/485

摘要： Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.

公开(公告)号：US20140052051A1

公开(公告)日：2014-02-20

申请号：US14064868

申请日：2013-10-28

申请人： FRANK TAGLIAFERRI ,  ALAN SMITH ,  DAVID ENSCORE ,  GAURAV TOLIA ,  MIREK BAUDYS

发明人： FRANK TAGLIAFERRI ,  ALAN SMITH ,  DAVID ENSCORE ,  GAURAV TOLIA ,  MIREK BAUDYS

IPC分类号： A61M37/00

CPC分类号： A61M37/00 ,  A61K9/7053 ,  A61K31/4468 ,  A61K31/485 ,  A61K47/12 ,  A61K47/183 ,  A61K47/38 ,  A61P5/50 ,  A61P23/02

摘要： Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.

摘要翻译： 公开了一种用于通过穿过受试者的生物膜的至少一个形成的途径将渗透组合物递送至受试者的贴剂，系统和方法。 所述贴剂包含基质，至少一个亲水性渗透物，其设置在所述基质内，其中所述渗透剂的至少一部分可以溶解在从所述受试者接收的生物水分中，以及至少一种渗透性增强剂。 还公开了用于通过穿过受试者的皮肤层的至少一个形成的途径将渗透组合物递送至受试者的系统和方法。

公开(公告)号：US20110190688A1

公开(公告)日：2011-08-04

申请号：US12893477

申请日：2010-09-29

申请人： Frank Tagliaferri ,  Alan Smith ,  David Enscore ,  Gaurav Tolia ,  Mirek Baudys

发明人： Frank Tagliaferri ,  Alan Smith ,  David Enscore ,  Gaurav Tolia ,  Mirek Baudys

IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K38/22 ,  A61K31/485 ,  A61K38/28 ,  A61K31/4468

CPC分类号： A61M37/00 ,  A61K9/7053 ,  A61K31/4468 ,  A61K31/485 ,  A61K47/12 ,  A61K47/183 ,  A61K47/38 ,  A61P5/50 ,  A61P23/02

摘要： Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.

摘要翻译： 公开了一种用于通过穿过受试者的生物膜的至少一个形成的途径将渗透组合物递送至受试者的贴剂，系统和方法。 所述贴剂包含基质，至少一个亲水性渗透物，其设置在所述基质内，其中所述渗透剂的至少一部分可以溶解在从所述受试者接收的生物水分中，以及至少一种渗透性增强剂。 还公开了用于通过穿过受试者的皮肤层的至少一个形成的途径将渗透组合物递送至受试者的系统和方法。