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139 条记录 (耗时 0.028 秒)

    Permeant delivery system and methods for use thereof
    4.
    发明申请
    Permeant delivery system and methods for use thereof 审中-公开
    渗透输送系统及其使用方法

    公开(公告)号：US20070031495A1

    公开(公告)日：2007-02-08

    申请号：US11455899

    申请日：2006-06-19

    申请人： Jonathan Eppstein ,  David Enscore ,  Frank Tagliaferri ,  Gaurav Tolia ,  Shulun Chang ,  Alan Smith ,  Yogi Patel ,  Stuart McRae

    发明人： Jonathan Eppstein ,  David Enscore ,  Frank Tagliaferri ,  Gaurav Tolia ,  Shulun Chang ,  Alan Smith ,  Yogi Patel ,  Stuart McRae

    IPC分类号： A61K9/24

    CPC分类号： A61K9/7053 ,  A61K9/0009

    摘要： Disclosed is a device for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface; and ii)an undissolved hydrophilic per meant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic per meant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject.

    摘要翻译： 公开了一种用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的装置。 所述装置包括递送贮存器，其包括：i）具有底表面并且在其中限定所述基质中的多个导管的不可生物降解的基质，所述多个导管的至少一部分与所述底表面连通; 和ii）未溶解的亲水剂，其中每个意图在其中设置多个基质管道的至少一部分，其中，当基质的底表面位于流体连通中时，每个意图的亲水剂可以与来自受试者的皮下流体接触 与至少一个形成的途径。 还公开了用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的系统和方法。

    Intranasal spray device containing pharmaceutical composition
    5.
    发明授权
    Intranasal spray device containing pharmaceutical composition 有权
    含有药物组合物的鼻内喷雾装置

    公开(公告)号：US09078814B2

    公开(公告)日：2015-07-14

    申请号：US13541325

    申请日：2012-07-03

    申请人： Peter James Watts ,  Jonathan David Castile ,  William Columbus Ian Lafferty ,  Alan Smith

    发明人： Peter James Watts ,  Jonathan David Castile ,  William Columbus Ian Lafferty ,  Alan Smith

    IPC分类号： A61F13/00 ,  A61K31/445 ,  A01N43/40 ,  A01N43/16 ,  A61K31/35 ,  A61K9/00 ,  A61K31/4468

    CPC分类号： A61K31/4468 ,  A61K9/0043 ,  A61K47/26 ,  A61K47/36 ,  A61M11/00 ,  A61M15/08

    摘要： An intrasnal spray device contains a composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.

    摘要翻译： 包含用于将芬太尼或其药学上可接受的盐鼻内递送给动物的组合物包括芬太尼或其药学上可接受的盐的水溶液和选自以下的药学上可接受的添加剂：（i）果胶和（ii） 泊洛沙姆和壳聚糖或其盐或衍生物; 条件是当组合物包含果胶时，其基本上不含二价金属离子; 并且与以相同剂量鼻内施用的芬太尼的简单水溶液相比，提供了芬太尼（C max）的峰值血浆浓度，其为使用芬太尼简单的水溶液，其在鼻内给药时的10至80％ 芬太尼剂量相同。 还公开了通过鼻内施用组合物治疗或治疗疼痛的方法。

    Method of intranasal administration of granisetron
    8.
    发明授权
    Method of intranasal administration of granisetron 有权
    格拉司琼鼻内给药方法

    公开(公告)号：US07947257B2

    公开(公告)日：2011-05-24

    申请号：US11004556

    申请日：2004-12-03

    申请人： Peter James Watts ,  Alan Smith ,  Jonathan Castile

    发明人： Peter James Watts ,  Alan Smith ,  Jonathan Castile

    IPC分类号： A61K9/08 ,  A61K9/12

    CPC分类号： A61K9/0043 ,  A61K31/435

    摘要： Compositions are provided for the intranasal administration of granisetron or a pharmaceutically acceptable salt thereof. Preferred compositions are in the form of an aqueous solution. Optionally, the compositions comprise chitosan, a salt or derivative thereof or a salt of a derivative of chitosan. The compositions can be used for the treatment or prevention of nausea and/or vomiting.

    摘要翻译： 提供了用于格拉司琼或其药学上可接受的盐的鼻内给药的组合物。 优选的组合物是水溶液的形式。 任选地，组合物包含壳聚糖，其盐或衍生物或壳聚糖衍生物的盐。 该组合物可用于治疗或预防恶心和/或呕吐。

    System and method for continuous analyte monitoring
    9.
    发明授权
    System and method for continuous analyte monitoring 有权
    用于连续分析物监测的系统和方法

    公开(公告)号：US07384396B2

    公开(公告)日：2008-06-10

    申请号：US10435221

    申请日：2003-05-08

    申请人： Mark A. Samuels ,  Jonathan A. Eppstein ,  Michael R. Hatch ,  Alan Smith ,  Mark Faupel

    发明人： Mark A. Samuels ,  Jonathan A. Eppstein ,  Michael R. Hatch ,  Alan Smith ,  Mark Faupel

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14514 ,  A61B5/00 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/150862 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15134 ,  A61B5/155 ,  A61B5/157 ,  A61B10/0045 ,  A61B2010/008

    摘要： A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system includes a tissue interface device suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit coupled to the tissue interface device. The tissue interface device includes a sensor positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor generates a sensor signal representative thereof. The monitor and control unit electrically or optically reads the sensor to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.

    摘要翻译： 一种用于从生物体提取生物流体并连续监测其特征的系统和方法。 该系统包括适于定位在生物体的生物膜的表面上或周围的组织界面装置以及耦合到组织界面装置的监测和控制单元。 组织接口装置包括定位在流体的流动路径中的传感器，用于在生物流体从形成在生物膜中的一个或多个人造开口流出时持续感测生物流体的特性。 传感器产生代表其的传感器信号。 监视器和控制单元以电或光学方式读取传感器，以连续的方式获得生物流体特性的浓度，例如特定分析物的浓度。

    Gas discharge lamp power supply
    10.
    发明申请
    Gas discharge lamp power supply 失效
    气体放电灯电源

    公开(公告)号：US20060214592A1

    公开(公告)日：2006-09-28

    申请号：US11091350

    申请日：2005-03-28

    申请人： William Hopkins ,  Anthony Banks ,  Alan Smith ,  Louis Pickvet ,  Robert Towe ,  Charles Schlemm

    发明人： William Hopkins ,  Anthony Banks ,  Alan Smith ,  Louis Pickvet ,  Robert Towe ,  Charles Schlemm

    IPC分类号： H01J13/46

    CPC分类号： H05B41/00

    摘要： A gas discharge lamp power supply having a base, a pair of opposed side walls extending from the base, and opposed first and second end walls extending from the base between the opposed side walls. The first end wall has a sloped wall extending angularly between the side walls, and two input terminals are mounted on the sloped wall. In another embodiment, the power supply has a control with a nonvolatile memory for storing an error code in response to a detected fault condition, thereby permitting the error code to be displayed upon power being removed from and then, subsequently reapplied.

    摘要翻译： 一种气体放电灯电源，具有基座，从基座延伸的一对相对的侧壁，以及在相对的侧壁之间从基部延伸的相对的第一和第二端壁。 第一端壁具有在侧壁之间成角度延伸的倾斜壁，并且两个输入端子安装在倾斜壁上。 在另一个实施例中，电源具有用于响应于检测到的故障状况而存储错误代码的非易失性存储器的控制，从而允许在从被重新施加电力并随后被重新应用的电力时显示错误代码。