公开(公告)号：US06444640B1

公开(公告)日：2002-09-03

申请号：US09409336

申请日：1999-09-30

申请人： Motoo Nagane ,  Webster Cavenee ,  Su Huang

发明人： Motoo Nagane ,  Webster Cavenee ,  Su Huang

IPC分类号： A61K3800

CPC分类号： A61K38/177 ,  A61K31/17 ,  A61K31/282 ,  A61K2300/00

摘要： The invention relates to compositions which include both a DR5 binding ligand, such as TRAIL, and a DNA damaging agent. In combination, these two materials have unexpected efficacy in treating conditions involving rapid cellular turnover, such as cancer, where an increase in apoptosis is desired. The compositions are particularly effective in treating neoplasias and diseases involving proliferative lesions, such as glioma.

摘要翻译： 本发明涉及包含DR5结合配体如TRAIL和DNA损伤剂的组合物。 综合起来，这两种材料在治疗涉及快速细胞周转的病症方面具有出人意料的疗效，如需要增加细胞凋亡的癌症。 组合物在治疗肿瘤和涉及增殖性病变的疾病如胶质瘤中特别有效。