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公开(公告)号：US08853453B2
公开(公告)日：2014-10-07
申请号：US13574833
申请日：2011-01-31
Applicant: Hari Mohan Sriram , Mukesh Kumar Madhra , Mukesh Kumar Sharma
Inventor： Hari Mohan Sriram , Mukesh Kumar Madhra , Mukesh Kumar Sharma
IPC: C07C231/14 , C07C227/18 , C07C231/12 , C07C231/02 , C07C227/16
CPC classification number: C07C231/14 , C07C227/16 , C07C227/18 , C07C231/02 , C07C231/12 , C07C229/22 , C07C237/06 , C07C237/22
Abstract: The present invention relates to processes for reducing impurities in lacosamide during the preparation of lacosamide. The invention provides processes for minimizing or removing impurities such as (2R)-2-(acetylamino)-3-(benzylamino)-3-oxopropyl acetate of Formula II or (2R)-2-propanoylamino-N-benzyl-3-methoxypropionamide of Formula III in lacosamide.
Abstract translation: 本发明涉及在制备lacosamide期间减少lacosamide中的杂质的方法。 本发明提供了最小化或除去杂质的方法，例如式II的（2R）-2-（乙酰氨基）-3-（苄基氨基）-3-氧代丙酸乙酯或（2R）-2-丙酰基氨基-N-苄基-3-甲氧基丙酰胺 的拉莫糖胺。
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2.发明授权公开(公告)号：US08093426B2
公开(公告)日：2012-01-10
申请号：US12327124
申请日：2008-12-03
Applicant: Mukesh Kumar Madhra , Pankaj Kumar Singh , Chandra Has Khanduri
Inventor： Mukesh Kumar Madhra , Pankaj Kumar Singh , Chandra Has Khanduri
IPC: C07C233/65
CPC classification number: C07C229/22 , C07B2200/07 , C07C231/14 , C07C237/06 , C07C237/22
Abstract: The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. Wherein R1 is —OH or —OMe; R2 is —OH or —NH—CH2—C6H5.
Abstract translation: 本发明涉及新化合物及其用于制备lacosamide的用途。 本发明还考虑了使用通式II，式IIa或式IIb的新化合物作为中间体来制备lacosamide的方法。 其中R1是-OH或-OMe; R2是-OH或-NH-CH2-C6H5。
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公开(公告)号：US20120004452A1
公开(公告)日：2012-01-05
申请号：US13154807
申请日：2011-06-07
Applicant: Mukesh Kumar MADHRA , Pankaj Kumar Singh , Chandra Has Khanduri
Inventor： Mukesh Kumar MADHRA , Pankaj Kumar Singh , Chandra Has Khanduri
IPC: C07C229/36 , C07C237/20
CPC classification number: C07C229/22 , C07B2200/07 , C07C231/14 , C07C237/06 , C07C237/22
Abstract: The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. Wherein R1 is —OH or —OMe; R2 is —OH or —NH—CH2—C6H5.
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公开(公告)号：US20090143472A1
公开(公告)日：2009-06-04
申请号：US12327124
申请日：2008-12-03
Applicant: Mukesh Kumar Madhra , Pankaj Kumar Singh , Chandra Has Khanduri
Inventor： Mukesh Kumar Madhra , Pankaj Kumar Singh , Chandra Has Khanduri
IPC: A61K31/165 , C07C237/04 , C07C237/14
CPC classification number: C07C229/22 , C07B2200/07 , C07C231/14 , C07C237/06 , C07C237/22
Abstract: The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. Wherein R1 is —OH or —OMe; R2 is —OH or —NH—CH2—C6H5.
Abstract translation: 本发明涉及新化合物及其用于制备lacosamide的用途。 本发明还考虑了使用通式II，式IIa或式IIb的新化合物作为中间体来制备lacosamide的方法。 其中R1是-OH或-OMe; R2是-OH或-NH-CH2-C6H5。
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Patent Agency Ranking
公开(公告)号：US20120004462A1
公开(公告)日：2012-01-05
申请号：US13154769
申请日：2011-06-07
Applicant: Mukesh Kumar MADHRA , Pankaj Kumar Singh , Chandra Has Khanduri
Inventor： Mukesh Kumar MADHRA , Pankaj Kumar Singh , Chandra Has Khanduri
IPC: C07C237/20
CPC classification number: C07C229/22 , C07B2200/07 , C07C231/14 , C07C237/06 , C07C237/22
Abstract: The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. Wherein R1 is —OH or —OMe; R2 is —OH or —NH—CH2—C6H5.
Abstract translation: 本发明涉及新化合物及其用于制备lacosamide的用途。 本发明还考虑了使用通式II，式IIa或式IIb的新化合物作为中间体来制备lacosamide的方法。 其中R1是-OH或-OMe; R2是-OH或-NH-CH2-C6H5。
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公开(公告)号：US20110071287A1
公开(公告)日：2011-03-24
申请号：US12990578
申请日：2009-05-01
Applicant: Mukesh Kumar Madhra , Pankaj Kumar Singh , Mukesh Sharma , Chandra Has Khanduri
Inventor： Mukesh Kumar Madhra , Pankaj Kumar Singh , Mukesh Sharma , Chandra Has Khanduri
IPC: C07D265/24
CPC classification number: C07D265/18
Abstract: The present invention relates to a process for the preparation of Efavirenz (Formula I), wherein triphosgene is used as a cyclizing agent.
Abstract translation: 本发明涉及制备依法韦仑（式I）的方法，其中使用三光气作为环化剂。
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公开(公告)号：US20130204042A1
公开(公告)日：2013-08-08
申请号：US13574833
申请日：2011-01-31
Applicant: Hari Mohan Sriram , Mukesh Kumar Madhra , Mukesh Kumar Sharma
Inventor： Hari Mohan Sriram , Mukesh Kumar Madhra , Mukesh Kumar Sharma
IPC: C07C231/14
CPC classification number: C07C231/14 , C07C227/16 , C07C227/18 , C07C231/02 , C07C231/12 , C07C229/22 , C07C237/06 , C07C237/22
Abstract: The present invention relates to processes for reducing impurities in lacosamide during the preparation of lacosamide. The invention provides processes for minimizing or removing impurities such as (2R)-2-(acetylamino)-3-(benzylamino)-3-oxopropyl acetate of Formula II or (2R)-2-propanoylamino-N-benzyl-3-methoxypropionamide of Formula III in lacosamide.
Abstract translation: 本发明涉及在制备lacosamide期间减少lacosamide中的杂质的方法。 本发明提供了最小化或除去杂质的方法，例如式II的（2R）-2-（乙酰氨基）-3-（苄基氨基）-3-氧代丙酸乙酯或（2R）-2-丙酰基氨基-N-苄基-3-甲氧基丙酰胺 的拉莫糖胺。
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公开(公告)号：US20130085304A1
公开(公告)日：2013-04-04
申请号：US13510981
申请日：2010-11-19
Applicant: Mukesh Kumar Madhra , Hari Mohan Sriram , Mukesh Kumar Sharma , Satish Chandra Jha
Inventor： Mukesh Kumar Madhra , Hari Mohan Sriram , Mukesh Kumar Sharma , Satish Chandra Jha
IPC: C07C231/00
CPC classification number: C07C231/00 , C07C231/22 , C07C237/22
Abstract: The present invention relates to processes for the preparation of crystalline polymorphic forms of lacosamide (Formula I), including processes for inter-conversion among such polymorphic forms.
Abstract translation: 本发明涉及制备拉科酰胺结晶多晶型物（式I）的方法，包括这些多晶型物之间的相互转化方法。
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9.发明授权公开(公告)号：US08378142B2
公开(公告)日：2013-02-19
申请号：US13154769
申请日：2011-06-07
Applicant: Mukesh Kumar Madhra , Pankaj Kumar Singh , Chandra Has Khanduri
Inventor： Mukesh Kumar Madhra , Pankaj Kumar Singh , Chandra Has Khanduri
IPC: C07C233/05
CPC classification number: C07C229/22 , C07B2200/07 , C07C231/14 , C07C237/06 , C07C237/22
Abstract: The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. Wherein R1 is —OH or —OMe; R2 is —OH or —NH—CH2—C6H5.
Abstract translation: 本发明涉及新化合物及其用于制备lacosamide的用途。 本发明还考虑了使用通式II，式IIa或式IIb的新化合物作为中间体来制备lacosamide的方法。 其中R1是-OH或-OMe; R2是-OH或-NH-CH2-C6H5。
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