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    Method of producing FR901228
    2.
    发明授权
    Method of producing FR901228 有权
    生产FR901228的方法

    公开(公告)号：US07396665B2

    公开(公告)日：2008-07-08

    申请号：US10362359

    申请日：2001-08-22

    申请人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    发明人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    IPC分类号： C12P21/06

    CPC分类号： C12P21/02 ,  C07K5/101

    摘要： Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion

    摘要翻译： 公开了具有结构（I）的脱肽和同系物，其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。 这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及​​用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者 移植后的移植物/组织存活。 还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法

    Method of producing FR901228
    6.
    发明授权
    Method of producing FR901228 有权
    生产FR901228的方法

    公开(公告)号：US07608280B2

    公开(公告)日：2009-10-27

    申请号：US12049746

    申请日：2008-03-17

    申请人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    发明人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    IPC分类号： A61K9/00 ,  A61K38/12 ,  C07K7/64

    CPC分类号： C12P21/02 ,  C07K5/101

    摘要： Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion. Also provided are crystalline forms of FR901228, e.g., type A and type B crystalline forms of FR901228.

    摘要翻译： 公开了具有结构（I）的脱肽和同系物，其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。 这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及​​用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者 移植后的移植物/组织存活。 还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法。 还提供了FR901228的结晶形式，例如FR901228的A型和B型结晶形式。

    Method of producing FR901228
    8.
    发明授权
    Method of producing FR901228 有权
    生产FR901228的方法

    公开(公告)号：US08445634B2

    公开(公告)日：2013-05-21

    申请号：US13473635

    申请日：2012-05-17

    申请人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    发明人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    IPC分类号： A61K9/00

    CPC分类号： C12P21/02 ,  C07K5/101

    摘要： Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

    摘要翻译： 公开了具有结构（I）的脱肽和同系物，其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。 这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及​​用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者 移植后的移植物/组织存活。 还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法。

    METHOD OF PRODUCING FR901228
    9.
    发明申请
    METHOD OF PRODUCING FR901228 有权
    生产FR901228的方法

    公开(公告)号：US20120225829A1

    公开(公告)日：2012-09-06

    申请号：US13473633

    申请日：2012-05-17

    申请人： Satoshi UEDA ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    发明人： Satoshi UEDA ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    IPC分类号： A61K38/07

    CPC分类号： C12P21/02 ,  C07K5/101

    摘要： Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

    摘要翻译： 公开了具有结构（I）的脱肽和同系物，其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。 这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及​​用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者 移植后的移植物/组织存活。 还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法。

    METHOD OF PRODUCING FR901228
    10.
    发明申请
    METHOD OF PRODUCING FR901228 审中-公开
    生产FR901228的方法

    公开(公告)号：US20090264343A1

    公开(公告)日：2009-10-22

    申请号：US12495239

    申请日：2009-06-30

    申请人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    发明人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    IPC分类号： A61K38/16 ,  C07K1/00 ,  A61P35/00

    CPC分类号： C12P21/02 ,  C07K5/101

    摘要： Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

    摘要翻译： 公开了具有结构（I）的脱肽和同系物，其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。 这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及​​用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者 移植后的移植物/组织存活。 还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法。