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公开(公告)号：US08877265B2
公开(公告)日：2014-11-04
申请号：US12840122
申请日：2010-07-20
申请人： Miyuki Tanaka , Muneo Yamada
发明人： Miyuki Tanaka , Muneo Yamada
IPC分类号： A61K36/886 , A61K31/575 , A23L1/30 , A61K31/58
CPC分类号： A61K31/58 , A23L33/105 , A23V2002/00 , A61K31/575 , A61K36/886 , A23V2250/2102 , A23V2200/326
摘要： The present invention provides: an Aloe vera extract that can be safely ingested, can be used as a material of food for preventing lifestyle diseases, contains an extremely low level of an anthraquinone (anthraquinone-based compound), and can be added to foods; and a method of producing the Aloe vera extract. A supercritical fluid extraction method can produce an Aloe vera extract containing a mixture that consists of a cyclolanostane compound and a lophenol compound in an amount of 1.0% by mass or more and having the following properties (1) and/or (2): (1) the mass mixing ratio of the cyclolanostane compound and lophenol compound is as follows: cyclolanostane compound:lophenol compound=6.3:2.7 to 5.1:4.9; and/or (2) the content of an anthraquinone-based compound is 0.001% by mass or less.
摘要翻译： 本发明提供：可以安全摄取的芦荟提取物，可以用作防止生活方式疾病的食品的材料，含有极低水平的蒽醌（蒽醌类化合物），可以添加到食品中; 以及生产芦荟提取物的方法。 超临界流体萃取法可以生产含有1.0质量％以上的环烷基苯化合物和苯酚化合物的混合物的芦荟提取物，具有以下性质（1）和/或（2）：（ 1）环氨基苯烷化合物和苯酚化合物的质量混合比如下：环丁烷化合物：苯酚化合物= 6.3:2.7〜5.1:4.9; 和/或（2）基于蒽醌的化合物的含量为0.001质量％以下。
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2.发明申请METHOD FOR PROMOTING SECRETION OF GLUCAGON-LIKE PEPTIDE-1 BY ADMINISTERING K-CASEIN 有权通过施用K-CASEIN促进葡萄球菌肽-1分泌的方法公开(公告)号：US20120108508A1
公开(公告)日：2012-05-03
申请号：US13313724
申请日：2011-12-07
申请人： Yousuke ITOH , Kouji NOMAGUCHI , Muneo YAMADA
发明人： Yousuke ITOH , Kouji NOMAGUCHI , Muneo YAMADA
CPC分类号： A61K38/012 , A23J1/202 , A23L2/52 , A23L33/19 , A23V2002/00 , A61K38/17 , A61K38/26 , A23V2200/328 , A23V2250/54246
摘要： The invention relates to a GLP-1 secretagogue and an inhibitor of postprandial rise in blood glucose, containing κ-casein as an active ingredient, and a food or drink for promoting GLP-1 secretion and an inhibitory food or drink of postprandial rise in blood glucose, containing a milk-derived casein protein wherein κ-casein accounts for 60% by mass or more of the milk-derived casein.
摘要翻译： 本发明涉及GLP-1促分泌素和餐后血糖升高抑制剂，其含有酪蛋白作为活性成分，以及用于促进GLP-1分泌的食物或饮料和餐后升高的抑制性食物或饮料 含有乳衍生酪蛋白的血糖，其中，酪蛋白占乳源酪蛋白的60质量％以上。
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3.发明授权公开(公告)号：US08114837B2
公开(公告)日：2012-02-14
申请号：US12704723
申请日：2010-02-12
申请人： Yousuke Itoh , Kouji Nomaguchi , Muneo Yamada
发明人： Yousuke Itoh , Kouji Nomaguchi , Muneo Yamada
CPC分类号： A61K38/012 , A23J1/202 , A23L2/52 , A23L33/19 , A23V2002/00 , A61K38/17 , A61K38/26 , A23V2200/328 , A23V2250/54246
摘要： The invention relates to a GLP-1 secretagogue and an inhibitor of postprandial rise in blood glucose, containing κ-casein as an active ingredient, and a food or drink for promoting GLP-1 secretion and an inhibitory food or drink of postprandial rise in blood glucose, containing a milk-derived casein protein wherein κ-casein accounts for 60% by mass or more of the milk-derived casein.
摘要翻译： 本发明涉及GLP-1促分泌素和餐后血糖升高抑制剂，其含有酪蛋白作为活性成分，以及用于促进GLP-1分泌的食物或饮料和餐后升高的抑制性食物或饮料 含有乳衍生酪蛋白的血糖，其中，酪蛋白占乳源酪蛋白的60质量％以上。
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4.发明申请ALOE VERA EXTRACT, METHOD OF PRODUCING ALOE VERA EXTRACT, AND HYPERGLYCEMIA IMPROVING AGENT 有权ALOE VERA提取物，生产ALEE VERA提取物的方法和高效液相色谱法改进剂公开(公告)号：US20110104314A1
公开(公告)日：2011-05-05
申请号：US12840122
申请日：2010-07-20
申请人： Miyuki Tanaka , Muneo Yamada
发明人： Miyuki Tanaka , Muneo Yamada
IPC分类号： A61K36/886 , A61P3/10
CPC分类号： A61K31/58 , A23L33/105 , A23V2002/00 , A61K31/575 , A61K36/886 , A23V2250/2102 , A23V2200/326
摘要： The present invention provides: an Aloe vera extract that can be safely ingested, can be used as a material of food for preventing lifestyle diseases, contains an extremely low level of an anthraquinone (anthraquinone-based compound), and can be added to foods; and a method of producing the Aloe vera extract. A supercritical fluid extraction method can produce an Aloe vera extract containing a mixture that consists of a cyclolanostane compound and a lophenol compound in an amount of 1.0% by mass or more and having the following properties (1) and/or (2): (1) the mass mixing ratio of the cyclolanostane compound and lophenol compound is as follows: cyclolanostane compound:lophenol compound=6.3:2.7 to 5.1:4.9; and/or (2) the content of an anthraquinone-based compound is 0.001% by mass or less.
摘要翻译： 本发明提供：可以安全摄取的芦荟提取物，可以用作防止生活方式疾病的食品的材料，含有极低水平的蒽醌（蒽醌类化合物），可以添加到食品中; 以及生产芦荟提取物的方法。 超临界流体萃取法可以生产含有1.0质量％以上的环烷基苯化合物和苯酚化合物的混合物的芦荟提取物，具有以下性质（1）和/或（2）：（ 1）环氨基苯烷化合物和苯酚化合物的质量混合比如下：环丁烷化合物：苯酚化合物= 6.3:2.7〜5.1:4.9; 和/或（2）基于蒽醌的化合物的含量为0.001质量％以下。
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公开(公告)号：US07674784B2
公开(公告)日：2010-03-09
申请号：US10572404
申请日：2005-03-30
申请人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
发明人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
CPC分类号： C07J53/00 , A23L2/52 , A23L33/105 , A61K31/575 , A61K36/886 , A61K36/899
摘要： A compound having a cyclolanostane skeleton such as 9,19-cyclolanostan-3-ol and 24-methylene-9,19-cyclolanostan-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.
摘要翻译： 作为用于改善高血糖症的药物或食品或饮料的活性成分，可以使用具有环内酯骨架的化合物，例如9,19-环诺烷三醇-3-醇和24-亚甲基-9,19-环唑烷-3-醇。
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公开(公告)号：US20080125379A1
公开(公告)日：2008-05-29
申请号：US11576676
申请日：2006-02-28
申请人： Miyuki Tanaka , Eriko Misawa , Noriko Habara , Muneo Yamada
发明人： Miyuki Tanaka , Eriko Misawa , Noriko Habara , Muneo Yamada
IPC分类号： A61K31/704
CPC分类号： A61K36/896 , A23L2/52 , A23L33/11 , A61K31/704
摘要： 3-O-β-D-Glucopyranosyl-4-methyl-ergost-7-en-3-ol or a composition containing 0.001 to 10% by dry mass of the aforementioned compound, which is an extract of a plant of the family Liliaceae or a fraction thereof containing the compound, is used as an active ingredient of a drug for improving pancreatic functions.
摘要翻译： 3-O-β-D-吡喃葡萄糖基-4-甲基麦角-7-烯-3-醇或含有0.001〜10％干质量的上述化合物的组合物，其为百合科植物的提取物 或其含有该化合物的部分用作改善胰腺功能的药物的活性成分。
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公开(公告)号：US20070032463A1
公开(公告)日：2007-02-08
申请号：US10572099
申请日：2005-03-30
申请人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
发明人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
IPC分类号： A61K31/56
CPC分类号： A61K36/886 , A23L33/11 , A61K31/575 , C07J9/00
摘要： A compound having a hyperglycemia improving effect and a hemoglobin Alc lowering action such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.
摘要翻译： 具有高血糖症改善作用和血红蛋白降低作用的化合物，例如4-甲基胆甾-7-烯-3-醇，4-甲基麦角甾-7-烯-3-醇和4-甲基蓖麻醇-7-烯-3-醇 用作药物或食物或饮料的活性成分，用于改善高血糖症。
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公开(公告)号：US08338403B2
公开(公告)日：2012-12-25
申请号：US12791670
申请日：2010-06-01
申请人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
发明人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
CPC分类号： A61K36/886 , A23L33/11 , A61K31/575 , C07J9/00
摘要： A compound having a hyperglycemia improving effect and a hemoglobin A1c lowering action such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.
摘要翻译： 具有高血糖症改善作用和血红蛋白A1c降低作用的化合物，例如4-甲基胆固醇-7-烯-3-醇，4-甲基麦角-7-烯-3-醇和4-甲基西泮-7-烯-3-醇 用作药物或食物或饮料的活性成分，用于改善高血糖症。
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9.发明申请GLUCAGON-LIKE PEPTIDE-1 SECRETAGOGUE, GLUCAGON-LIKE PEPTIDE-1 SECRETAGOGUE FOOD OR DRINK, INHIBITOR OF POSTPRANDIAL RISE IN BLOOD GLUCOSE, AND INHIBITORY FOOD OR DRINK OF POSTPRANDIAL RISE IN BLOOD GLUCOSE 审中-公开GLUCAGON-LIKE PEPTIDE-1 SECRETAGOGUE，GLUCAGON-like PIPTIDE-1 SECRETAGOGUE FOOD OR DRINK，INHIBITOR POS POSRRANDIAL RISE IN BLOOD GLUCOSE，AND INIBIBIORY FOOD OR DRINK OF POSTPRANDIAL RISE IN BLOOD GLUCOSE公开(公告)号：US20090131316A1
公开(公告)日：2009-05-21
申请号：US12088276
申请日：2006-09-29
申请人： Yousuke Itoh , Kouji Nomaguchi , Muneo Yamada
发明人： Yousuke Itoh , Kouji Nomaguchi , Muneo Yamada
CPC分类号： A61K38/012 , A23J1/202 , A23L2/52 , A23L33/19 , A23V2002/00 , A61K38/17 , A61K38/26 , A23V2200/328 , A23V2250/54246
摘要： The invention relates to a GLP-1 secretagogue and an inhibitor of postprandial rise in blood glucose, containing κ-casein as an active ingredient, and a food or drink for promoting GLP-1 secretion and an inhibitory food or drink of postprandial rise in blood glucose, containing a milk-derived casein protein wherein κ-casein accounts for 60% by mass or more of the milk-derived casein.
摘要翻译： 本发明涉及一种GLP-1促分泌素和含有κ-酪蛋白作为活性成分的餐后血糖升高抑制剂，以及用于促进GLP-1分泌的食品或饮料以及餐后血液升高的抑制食品或饮料 葡萄糖，其含有乳原酪蛋白，其中，κ-酪蛋白占乳源性酪蛋白的60质量％以上。
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10.发明授权Glycoside having 4-methylergost-7-en-3-ol skeleton and hyperglycemia improving agent 有权具有4-甲基麦角甾-7-烯-3-醇骨架的糖苷和高血糖症改善剂公开(公告)号：US07534770B2
公开(公告)日：2009-05-19
申请号：US10564464
申请日：2005-03-30
申请人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
发明人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
IPC分类号： A01N45/00 , C07G3/00 , A61K36/886
CPC分类号： C07J17/005 , A23L33/105 , A61K36/886 , A61K36/896
摘要： 3-O-β-D-Glucopyranosyl-4-methylergost-7-en-3-ol or a composition containing 0.001% by mass or more of the aforementioned compound, which is an extract of a plant of the family Liliaceae containing the compound or a fraction thereof, is used as an active ingredient of a hyperglycemia improving agent.
摘要翻译： 3-O-β-D-吡喃葡萄糖基-4-甲基麦角-7-烯-3-醇或含有0.001质量％以上上述化合物的组合物，其为含有化合物的百合科植物的提取物 或其一部分用作高血糖改善剂的活性成分。
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