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    Compounds and methods for the treatment of bacterial dysentery using antibiotics and toxin binding oligosaccharide compositions
    3.
    发明授权
    Compounds and methods for the treatment of bacterial dysentery using antibiotics and toxin binding oligosaccharide compositions 失效
    使用抗生素和毒素结合寡糖组合物治疗细菌性痢疾的化合物和方法

    公开(公告)号：US06224891B1

    公开(公告)日：2001-05-01

    申请号：US09255709

    申请日：1999-02-23

    申请人： David John Rafter ,  Robert Murray Ratcliffe ,  Bradley G. Thompson ,  Glen D. Armstrong

    发明人： David John Rafter ,  Robert Murray Ratcliffe ,  Bradley G. Thompson ,  Glen D. Armstrong

    IPC分类号： A01N2526

    CPC分类号： A61K31/70 ,  A61K45/06 ,  A61K47/52 ,  Y02A50/473 ,  Y02A50/475 ,  A61K2300/00

    摘要： This invention relates to the treatment of diarrhea and related conditions caused by pathogenic E. coli infection. More specifically, this invention is drawn to the unexpected discovery that by administering a composition which binds and removes the shiga like toxins (SLT) produced by pathogenic E. coli whenever an antibiotic is administered, improved treatment is provided. Novel compositions containing both antibiotic and toxin binding composition and methods of treatment which use simultaneous administration toxin binding composition whenever antibiotic is administered are provided. These compositions and methods kill the enteric E. coli organisms which produce the conditions and neutralize the SLT produced by the organisms and/or released from the organisms when they are killed. Thus, these compositions and methods are better able to ameliorate the symptoms of the infection and inhibit progression of this infection into hemolytic uremic syndrome (HUS) than conventional treatment.

    摘要翻译： 本发明涉及由病原性大肠杆菌感染引起的腹泻及相关病症的治疗。 更具体地，本发明涉及意想不到的发现：通过施用结合和除去由致病性大肠杆菌产生的志贺样毒素（SLT）的组合物，每当施用抗生素时，提供改进的治疗。 提供了含抗生素和毒素结合组合物的新型组合物和每当施用抗生素时同时施用毒素结合组合物的治疗方法。 这些组合物和方法杀死产生条件的肠道大肠杆菌生物体，并中和由生物体产生的SLT和/或当它们被杀死时从生物体中释放出来。 因此，这些组合物和方法能够比常规治疗更好地改善感染的症状并抑制这种感染进入溶血性尿毒综合征（HUS）的进展。

    Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals
    6.
    发明授权
    Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals 失效
    合成2-氨基-2-脱氧糖苷和2-氨基-2-脱氧糖苷

    公开(公告)号：US4362720A

    公开(公告)日：1982-12-07

    申请号：US77012

    申请日：1979-09-19

    申请人： Raymond U. Lemieux ,  R. Murray Ratcliffe

    发明人： Raymond U. Lemieux ,  R. Murray Ratcliffe

    IPC分类号： C07H3/06 ,  C07H5/06 ,  C07H13/08 ,  C07H15/04 ,  A61K35/14 ,  C07H13/06

    CPC分类号： C07H13/08 ,  C07H15/04 ,  C07H3/06 ,  C07H5/06 ,  Y10S530/816

    摘要： O-acetylated glycals react with ceric ammonium nitrate in the presence of sodium azide to provide, in good yield, O-acetylated 2-azido-2-deoxy glycosyl nitrates. These nitrates can be used to prepare 2-amino-2-deoxy sugars, such as D-galactosamine and lactosamine. The O-acetylated 2-azido-2-deoxy glycosyl nitrates can alternately be converted to O-acetylated 2-azido-2-deoxy glycosyl halides which are useful in the preparation of O-acetylated 2-azido-2-deoxy glycosides, which in turn can be reduced to 2-amino-2-deoxy glycosides. Of particular interest are the syntheses of 2-amino-2-deoxy glycosides which correspond to the terminal units of the antigenic determinant for the human A blood group. Attachment of these glycosides to a solid support provides immunoabsorbents which efficiently and preferentially absorb anti-A antibodies from blood plasma.

    摘要翻译： O-乙酰化的甘氨酸在叠氮化钠存在下与硝酸铈铵反应，以高产率提供O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐。 这些硝酸盐可用于制备2-氨基-2-脱氧糖，如D-半乳糖胺和乳糖胺。 O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐可以替代地转化成O-乙酰化的2-叠氮基-2-脱氧糖基卤化物，其可用于制备O-乙酰化的2-叠氮基-2-脱氧糖苷，其中 又可以还原成2-氨基-2-脱氧糖苷。 特别感兴趣的是对应于人A血型的抗原决定簇的末端单元的2-氨基-2-脱氧糖苷的合成。 将这些糖苷连接到固体支持物上提供有效和优先地从血浆吸收抗-A抗体的免疫吸收剂。

    Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals
    7.
    发明授权
    Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals 失效
    合成2-氨基-2-脱氧糖苷和2-氨基-2-脱氧糖苷

    公开(公告)号：US4308376A

    公开(公告)日：1981-12-29

    申请号：US77014

    申请日：1979-09-19

    申请人： Raymond U. Lemieux ,  R. Murray Ratcliffe

    发明人： Raymond U. Lemieux ,  R. Murray Ratcliffe

    IPC分类号： C07D309/30 ,  A61K31/7028 ,  A61K31/715 ,  A61K39/00 ,  A61P37/00 ,  C07H3/06 ,  C07H5/02 ,  C07H5/04 ,  C07H5/06 ,  C07H13/06 ,  C07H13/08 ,  C07H15/04 ,  G01N33/53 ,  C07H11/02

    CPC分类号： C07H5/06 ,  C07H13/08 ,  C07H15/04 ,  C07H3/06

    摘要： O-acetylated glycals react with ceric ammonium nitrate in the presence of sodium azide to provide, in good yield, O-acetylated 2-azido-2-deoxy glycosyl nitrates. These nitrates can be used to prepare 2-amino-2-deoxy sugars, such as D-galactosamine and lactosamine. The O-acetylated 2-azido-2-deoxy glycosyl nitrates can alternately be converted to O-acetylated 2-azido-2-deoxy glycosyl halides which are useful in the preparation of O-acetylated 2-azido-2-deoxy glycosides, which in turn can be reduced to 2-amino-2-deoxy glycosides. Of particular interest are the syntheses of 2-amino-2-deoxy glycosides which correspond to the terminal units of the antigenic determinant for the human A blood group. Attachment of these glycosides to a solid support provides immunoabsorbents which efficiently and preferentially absorb anti-A antibodies from blood plasma.

    摘要翻译： O-乙酰化的甘氨酸在叠氮化钠存在下与硝酸铈铵反应，以高产率提供O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐。 这些硝酸盐可用于制备2-氨基-2-脱氧糖，如D-半乳糖胺和乳糖胺。 O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐可以替代地转化成O-乙酰化的2-叠氮基-2-脱氧糖基卤化物，其可用于制备O-乙酰化的2-叠氮基-2-脱氧糖苷，其中 又可以还原成2-氨基-2-脱氧糖苷。 特别感兴趣的是对应于人A血型的抗原决定簇的末端单元的2-氨基-2-脱氧糖苷的合成。 将这些糖苷连接到固体支持物上提供有效和优先地从血浆吸收抗-A抗体的免疫吸收剂。

    Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals
    8.
    发明授权
    Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals 失效
    合成2-氨基-2-脱氧糖苷和2-氨基-2-脱氧糖苷

    公开(公告)号：US4195174A

    公开(公告)日：1980-03-25

    申请号：US894366

    申请日：1978-04-07

    申请人： Raymond U. Lemieux ,  R. Murray Ratcliffe

    发明人： Raymond U. Lemieux ,  R. Murray Ratcliffe

    IPC分类号： C07D309/30 ,  A61K31/7028 ,  A61K31/715 ,  A61K39/00 ,  A61P37/00 ,  C07H3/06 ,  C07H5/02 ,  C07H5/04 ,  C07H5/06 ,  C07H13/06 ,  C07H13/08 ,  C07H15/04 ,  G01N33/53 ,  C07H11/02

    CPC分类号： C07H5/06 ,  C07H13/08 ,  C07H15/04 ,  C07H3/06

    摘要： O-acetylated glycals react with ceric ammonium nitrate in the presence of sodium azide to provide, in good yield, O-acetylated 2-azido-2-deoxy glycosyl nitrates. These nitrates can be used to prepare 2-amino-2-deoxy sugars, such as D-galactosamine and lactosamine. The O-acetylated 2-azido-2-deoxy glycosyl nitrates can alternately be converted to O-acetylated 2-azido-2-deoxy glycosyl halides which are useful in the preparation of O-acetylated 2-azido-2-deoxy glycosides, which in turn can be reduced to 2-amino-2-deoxy glycosides. Of particular interest are the syntheses of 2-amino-2-deoxy glycosides which correspond to the terminal units of the antigenic determinant for the human A blood group. Attachment of these glycosides to a solid support provides immunoabsorbents which efficiently and preferentially absorb anti-A antibodies from blood plasma.

    摘要翻译： O-乙酰化的甘氨酸在叠氮化钠存在下与硝酸铈铵反应，以高产率提供O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐。 这些硝酸盐可用于制备2-氨基-2-脱氧糖，如D-半乳糖胺和乳糖胺。 O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐可以替代地转化成O-乙酰化的2-叠氮基-2-脱氧糖基卤化物，其可用于制备O-乙酰化的2-叠氮基-2-脱氧糖苷，其中 又可以还原成2-氨基-2-脱氧糖苷。 特别感兴趣的是对应于人A血型的抗原决定簇的末端单元的2-氨基-2-脱氧糖苷的合成。 将这些糖苷连接到固体支持物上提供有效和优先地从血浆吸收抗-A抗体的免疫吸收剂。