公开(公告)号：US06495348B1

公开(公告)日：2002-12-17

申请号：US09266965

申请日：1999-03-12

Applicant: David H. Sherman ,  Yingqing Mao ,  Mustafa Varoglu ,  Min He ,  Paul Sheldon

Inventor： David H. Sherman ,  Yingqing Mao ,  Mustafa Varoglu ,  Min He ,  Paul Sheldon

IPC: C12P1962

CPC classification number: C12N9/93 ,  C07K14/36 ,  C12N9/0004 ,  C12N9/10 ,  C12N9/1007 ,  C12N9/12 ,  C12N9/14 ,  C12N9/88 ,  C12N15/52 ,  C12P17/182 ,  C12Q1/6827

Abstract: The invention provides a biosynthetic gene cluster for mitomycin, for example, a mitomycin biosynthetic cluster from organisms such as Streptomyces, for instance, S. lavendulae, as well as methods of using gene(s) within the cluster to alter antibiotic biosynthesis and to prepare a polyketide synthase.

Abstract translation: 本发明提供丝裂霉素的生物合成基因簇，例如来自诸如链霉菌（Streptomyces）等生物体的丝裂霉素生物合成簇，例如链霉菌，以及使用簇内的基因来改变抗生素生物合成并制备 聚酮化合物合酶。