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公开(公告)号：US20240327812A1
公开(公告)日：2024-10-03
申请号：US18632018
申请日：2024-04-10
CPC分类号： C12N9/22 , C12N9/1007 , C12N9/78 , C12N15/111 , C12N15/86 , C07K2319/80 , C12N2750/14143 , C12Y201/01037 , C12Y305/04002
摘要： The present disclosure provides compositions of CRISPR associated (Cas) effector proteins fused to partner proteins. Compositions typically comprise a guide nucleic acid. Also disclosed are the methods and systems for detecting and modifying target nucleic acids using the same. The cells, progenies thereof, and populations thereof produced by the compositions, methods, or systems provided herein are also described.
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2.发明公开公开(公告)号：US20240254462A1
公开(公告)日：2024-08-01
申请号：US18405286
申请日：2024-01-05
发明人： Laura Anh Nguyen , Jeremiah D. Farelli , Adam Walter Scheidegger , Abigail Elizabeth Witt , Justin Chen , James Scott Sullivan
CPC分类号： C12N9/22 , A61K9/5123 , C12N9/1007 , C12N15/113 , C12N15/86 , A61K38/00 , C07K2319/81 , C12N2310/20 , C12Y305/01098
摘要： The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of a secreted frizzled related protein 1 (SFRP1) gene by targeting an SFRP1 expression control region and methods of use thereof for treating an SFRP1 associated disorder, e.g., hair loss.
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公开(公告)号：US12050597B2
公开(公告)日：2024-07-30
申请号：US18078876
申请日：2022-12-09
申请人： Splunk Inc.
IPC分类号： G06F16/00 , A61K39/245 , C12N7/00 , C12N9/10 , C12N9/12 , C12N9/16 , G06F3/0482 , G06F16/242 , G06F16/245 , G06F16/25 , A61K39/00
CPC分类号： G06F16/2428 , A61K39/245 , C12N7/00 , C12N9/1007 , C12N9/1241 , C12N9/16 , C12Y201/01056 , C12Y207/0705 , C12Y301/03033 , G06F3/0482 , G06F16/245 , G06F16/252 , A61K2039/53 , C07K2319/21 , C12N2710/16134
摘要： An improved data intake and query system that can perform and display ingest-time and search-time field extraction, redaction, copy, and/or categorization is described herein. As described herein, ingest-time field extraction, redaction, copy, and/or categorization may refer to field or field value extraction, redaction, copy, and/or categorization that is performed by a log observer system of the data intake and query system on raw machine data as the raw machine data is ingested or received from a publisher. As described herein, search-time field extraction, redaction, copy, and/or categorization may refer to field or field value extraction, redaction, copy, and/or categorization that is performed by the log observer system and/or other components of the improved data intake and query system on historical raw machine data that has already been ingested and indexed by the improved data intake and query system.
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公开(公告)号：US20240216388A1
公开(公告)日：2024-07-04
申请号：US18609709
申请日：2024-03-19
申请人： INSTITUT CURIE , INSERM
IPC分类号： A61K31/546 , A61K38/00 , A61K39/00 , A61K45/06 , A61P35/02 , C07K16/28 , C12N9/10 , C12N15/113 , G01N33/50
CPC分类号： A61K31/546 , A61P35/02 , C07K16/2818 , C07K16/2827 , C12N15/113 , G01N33/5008 , A61K38/00 , A61K2039/505 , A61K45/06 , C07K2317/73 , C07K2317/76 , C12N9/1007 , C12N2310/12 , C12N2310/14 , C12N2310/531
摘要： The present invention relates to an inhibitor of H3K9 histone methyl transferase SUV39H1 for use in combination with at least one immune checkpoint modulator in the treatment of cancer.
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公开(公告)号：US20240191284A1
公开(公告)日：2024-06-13
申请号：US18588956
申请日：2024-02-27
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12N9/10 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/53
CPC分类号： C12Q1/6827 , C12N9/1007 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/5308 , C12N2501/70 , C12N2501/71 , C12N2501/724 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US11987834B2
公开(公告)日：2024-05-21
申请号：US16433657
申请日：2019-06-06
CPC分类号： C12Q1/48 , C07K14/4708 , C12N9/1007 , C12N9/1014 , C12N9/107 , C12N9/1096 , C12Q1/527 , C12Y201/01005 , G01N33/53
摘要： The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts.
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公开(公告)号：US11981937B2
公开(公告)日：2024-05-14
申请号：US16810658
申请日：2020-03-05
申请人： Willem Vermaas
发明人： Willem Vermaas
CPC分类号： C12N9/1007 , C12P7/62 , C12Y201/01015
摘要： The disclosure relates to the production of methyl laurate by genetically engineered photosynthetic microorganisms. In particular, provided herein are methods and compositions for producing methyl laurate from carbon dioxide and water in genetically engineered cyanobacteria and other photosynthetic microorganisms.
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公开(公告)号：US20240124850A1
公开(公告)日：2024-04-18
申请号：US18277033
申请日：2022-03-03
CPC分类号： C12N7/00 , C07K14/005 , C12N5/0018 , C12N5/0682 , C12N5/0686 , C12N9/0016 , C12N9/1007 , C12N9/93 , C12N15/52 , C12N2500/32 , C12N2501/999 , C12N2750/14122 , C12N2750/14151 , C12Y114/16001 , C12Y201/01045 , C12Y603/01002
摘要： Disclosed herein are cells and cell lines that are selected for retention of at least two exogenous nucleic acid constructs using a single selective pressure. Also disclosed herein are compositions and methods for generating recombinant cells and cell lines using a single selective pressure.
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公开(公告)号：US20240124537A1
公开(公告)日：2024-04-18
申请号：US18516722
申请日：2023-11-21
发明人： Jason FERNANDES , Sean HIGGINS , Sarah DENNY , Ross WHITE , Emeric Jean Marius CHARLES , Addison WRIGHT , Benjamin DEMAREE , Manuel MOHR , Wenyuan ZHOU , Benjamin OAKES
IPC分类号： C07K14/47 , C12N9/10 , C12N15/113
CPC分类号： C07K14/4703 , C12N9/1007 , C12N15/113 , C07K2319/09 , C07K2319/81 , C12N2310/20 , C12N2310/531
摘要： Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.
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公开(公告)号：US20240116992A1
公开(公告)日：2024-04-11
申请号：US18263833
申请日：2022-02-02
发明人： David W. Howell , Sarah E. Bondos , Rebecca M. Booth , Christi Parham , Dat P. Truong , Rebecca E. Skouby
IPC分类号： C07K14/435 , C12N9/02 , C12N9/10 , C12N9/84 , C12N9/88 , C12N9/90 , C12N9/92 , C12N11/02 , C12P17/18 , C12P37/00
CPC分类号： C07K14/43581 , C12N9/0004 , C12N9/0071 , C12N9/1007 , C12N9/1029 , C12N9/84 , C12N9/88 , C12N9/90 , C12N9/92 , C12N11/02 , C12P17/182 , C12P37/00 , C12Y114/16004 , C12Y114/20001 , C12Y121/03001 , C12Y201/01004 , C12Y203/01164 , C12Y203/01175 , C12Y203/01194 , C12Y305/01011 , C12Y401/01028 , C12Y501/01017 , C12Y503/01018 , C07K2319/735
摘要： Provided herein are compositions and methods for stabilizing enzymes. Also provided are systems, compositions and methods for using the stabilized enzymes to produce a desired compound.
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