公开(公告)号：US5461168A

公开(公告)日：1995-10-24

申请号：US114468

申请日：1993-08-31

Applicant: Mitsugi Shibano ,  Mutsauo Suzuki ,  Shunshi Kojima

Inventor： Mitsugi Shibano ,  Mutsauo Suzuki ,  Shunshi Kojima

IPC: A61K31/695 ,  A61P33/00 ,  A61P33/10 ,  C07D493/22 ,  C07F7/18 ,  C07H19/01 ,  C07D315/00

CPC classification number: C07D493/22 ,  C07H19/01 ,  Y02P20/55

Abstract: An intermediate useful in the synthesis of milbemycin derivatives having an ether bond at the 13-position and which is represented by the general formula (IIId): ##STR1## wherein R represents a methyl group, an ethyl group, an isopropyl group or a sec-butyl group, and R.sup.5 and R.sup.6' each individually represents a hydrogen atom or a protecting group,and related precursors as well as to a process for producing these intermediates.

Abstract translation: （IIId）表示的具有在13位具有醚键的密尔伯霉素衍生物的合成中间体：其中R表示甲基，乙基，异丙基 或仲丁基，R5和R6'各自独立地表示氢原子或保护基，以及相关前体以及制备这些中间体的方法。