公开(公告)号：US09751894B2

公开(公告)日：2017-09-05

申请号：US15369181

申请日：2016-12-05

申请人： NAEJA-RGM PHARMACEUTICALS INC.

发明人： Samarendra Nath Maiti ,  Dai Quoc Nguyen ,  Andhe V. N. Reddy ,  Judy Yip ,  Chan Minh Ha ,  Rong Ling ,  Rudong Shan ,  Madhava Reddy Madala

IPC分类号： C07D501/46 ,  C07D501/56 ,  A61K31/546 ,  C07D501/04

CPC分类号： C07D501/56 ,  A61K31/546 ,  C07D501/04

摘要： Cephem compounds, pharmaceutically acceptable salts thereof, and methods of using same, wherein the compound has a bicyclic nitrogen-containing aromatic heterocyclic ring as the quaternary ammoniomethyl group at the 3-position and one or both of a terminal amidine residue (substituted or unsubstituted) attached to an aryl or a 5- or 6-membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain, or a terminal guanidine residue attached to an aryl or a 5- or 6-membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain.

公开(公告)号：US20170166587A1

公开(公告)日：2017-06-15

申请号：US15369181

申请日：2016-12-05

申请人： NAEJA-RGM PHARMACEUTICALS INC.

发明人： Samarendra Nath MAITI ,  Dai Quoc NGUYEN ,  Andhe V.N. REDDY ,  Judy YIP ,  Chan Minh HA ,  Rong LING ,  Rudong SHAN ,  Madhava Reddy MADALA

IPC分类号： C07D501/56 ,  C07D501/04 ,  A61K31/546

CPC分类号： C07D501/56 ,  A61K31/546 ,  C07D501/04

摘要： Cephem compounds, pharmaceutically acceptable salts thereof, and methods of using same, wherein the compound has a bicyclic nitrogen-containing aromatic heterocyclic ring as the quaternary ammoniomethyl group at the 3-position and one or both of a terminal amidine residue (substituted or unsubstituted) attached to an aryl or a 5- or 6-membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain, or a terminal guanidine residue attached to an aryl or a 5- or 6-membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain.