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    Cephem derivative having catechol group
    1.
    发明授权
    Cephem derivative having catechol group 有权
    具有儿茶酚基团的头孢衍生物

    公开(公告)号：US09290515B2

    公开(公告)日：2016-03-22

    申请号：US14349227

    申请日：2012-10-03

    申请人： SHIONOGI & CO., LTD.

    发明人： Kenji Yamawaki ,  Masayuki Sano ,  Jun Sato

    IPC分类号： C07D501/56 ,  C07D501/46

    CPC分类号： C07D501/56 ,  C07D501/46

    摘要： A compound represented by formula (I) or a pharmaceutically acceptable salt thereof wherein A represents a group represented by one of formulae (i)-(iii); B represents a group represented by formula (v) or (vi); and E represents a substituted or unsubstituted heterocyclic group having a cationic nitrogen atom.

    摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐，其中A表示由式（i） - （iii）之一表示的基团; B表示由式（v）或（vi）表示的基团; E表示具有阳离子氮原子的取代或未取代的杂环基。

    Cephem derivative
    2.
    发明授权
    Cephem derivative 有权
    Cephem衍生物

    公开(公告)号：US09085589B2

    公开(公告)日：2015-07-21

    申请号：US13642959

    申请日：2011-04-27

    申请人： Hiroki Kusano ,  Kenji Yamawaki

    发明人： Hiroki Kusano ,  Kenji Yamawaki

    IPC分类号： A61K31/546 ,  C07D501/56 ,  C07D501/42 ,  C07D501/44 ,  C07D501/46 ,  C07D519/00 ,  C07D519/06 ,  C07D501/54

    CPC分类号： C07D501/56 ,  C07D501/42 ,  C07D501/44 ,  C07D501/46 ,  C07D501/54 ,  C07D519/00 ,  C07D519/06

    摘要： Provided is a cephem compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and a pharmaceutical composition comprising the same. The cephem compound has the formula (I): where W and U are as defined in the specification; R1 is as defined in the specification; R2A and R2B are as defined in the specification, provided that R2A and R2B are not taken together to form an optionally substituted oxime group when R1 is aminothiazole or aminothiadiazole optionally protected at the amino group; ring A is a benzene ring or a 6-membered aromatic heterocyclic group having 1-3 nitrogen atoms; R3 is a hydrogen atom, —OCH3 or —NH—CH(═O); k is an integer from 0 to 2; R4 is as defined in the specification; and D and E are as defined in accordance with a) or b) described in the specification.

    摘要翻译： 本发明提供一种具有广谱抗菌谱的头孢烯化合物，特别是对产生β-内酰胺酶的革兰氏阴性细菌表现出有效的抗微生物活性，以及​​包含其的药物组合物。 头孢烯化合物具有式（I）：其中W和U如说明书中所定义; R1如规范中所定义; R2A和R2B如说明书中所定义，条件是当R 1为氨基噻唑或氨基噻二唑任选在该氨基保护时，R2A和R2B不一起形成任选取代的肟基; 环A是苯环或具有1-3个氮原子的6元芳族杂环基; R3是氢原子，-OCH3或-NH-CH（= O）; k是0至2的整数; R4如规范中所定义; 和D和E如在说明书中描述的a）或b）所定义。

    CEPHALOSPORIN COMPOUND
    3.
    发明申请
    CEPHALOSPORIN COMPOUND 审中-公开
    CEPHALOSPORIN化合物

    公开(公告)号：US20150025053A1

    公开(公告)日：2015-01-22

    申请号：US14333966

    申请日：2014-07-17

    申请人： Cubist Pharmaceuticals, Inc.

    发明人： Yong He ,  Yu Gui Gu ,  Ning Yin

    IPC分类号： C07D501/60 ,  C07D501/04

    CPC分类号： C07D501/60 ,  C07D501/04 ,  C07D501/56

    摘要： The cephalosporin compound of formula (I) is disclosed, which exhibits antibiotic activity against Gram-negative (e.g., Pseudomonas aeruginosa) and Gram-positive (e.g., methicillin-resistant Staphylococcus aureus) bacteria. Methods of manufacturing the compound of formula (I), and uses of the compound in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.

    摘要翻译： 公开了式（I）的头孢菌素化合物，其表现出抗革兰氏阴性（例如铜绿假单胞菌）和革兰氏阳性（例如耐甲氧西林金黄色葡萄球菌）细菌的抗生素活性。 还公开了制备式（I）化合物的方法，以及该化合物在制备药物组合物和抗菌应用中的用途。

    NOVEL CEPHEM DERIVATIVE
    5.
    发明申请
    NOVEL CEPHEM DERIVATIVE 有权
    新CEPHEM DERIVATIVE

    公开(公告)号：US20130096299A1

    公开(公告)日：2013-04-18

    申请号：US13642959

    申请日：2011-04-27

    申请人： Hiroki Kusano ,  Kenji Yamawaki

    发明人： Hiroki Kusano ,  Kenji Yamawaki

    IPC分类号： C07D501/56 ,  C07D519/06 ,  C07D501/54

    CPC分类号： C07D501/56 ,  C07D501/42 ,  C07D501/44 ,  C07D501/46 ,  C07D501/54 ,  C07D519/00 ,  C07D519/06

    摘要： Provided is a cephem compound which has a wide antimicrobial spectrum, and in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical composition comprising the same.A Compound of the formula (I): wherein W and U are as defined in the specification; R1 is as defined in the specification; R2A and R2B are as defined in the specification, provided that R2A and R2B are not taken together to form an optionally substituted oxime group when R1 is aminothiazole or aminothiadiazole optionally protected at the amino group; ring A is a benzene ring or a 6-membered aromatic heterocyclic group having 1-3 nitrogen atoms; R3 is a hydrogen atom, —OCH3 or —NH—CH(═O); k is an integer from 0 to 2; R4 is as defined in the specification; and D and E are as defined in accordance with a) or b) described in the specification.

    摘要翻译： 提供了具有广谱抗菌谱的头孢烯化合物，并且特别表现出对产生β-内酰胺酶的革兰氏阴性细菌具有强力的抗微生物活性，以及​​包含其的药物组合物。 式（I）的化合物：其中W和U如说明书中所定义; R1如规范中所定义; R2A和R2B如说明书中所定义，条件是当R 1为氨基噻唑或氨基噻二唑任选在该氨基保护时，R2A和R2B不一起形成任选取代的肟基; 环A是苯环或具有1-3个氮原子的6元芳族杂环基; R3是氢原子，-OCH3或-NH-CH（= O）; k是0至2的整数; R4如规范中所定义; 和D和E如在说明书中描述的a）或b）所定义。

    Broad spectrum cephem compounds
    6.
    发明授权
    Broad spectrum cephem compounds 失效
    广谱头孢烯化合物

    公开(公告)号：US07384928B2

    公开(公告)日：2008-06-10

    申请号：US10507502

    申请日：2003-03-18

    申请人： Yasuhiro Nishitani ,  Yoshinori Yamano

    发明人： Yasuhiro Nishitani ,  Yoshinori Yamano

    IPC分类号： C07D501/46 ,  A61K31/546 ,  A61P31/04 ,  C07D277/593

    CPC分类号： C07D501/56 ,  A61K31/546 ,  C07D501/00

    摘要： A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.

    摘要翻译： 下式的化合物：其中T是S，SO或O; X是卤素，CN，任选被低级烷基，低级烷基，低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基（其中取代基是 任选取代的单低级烷基，任选取代的低级亚烷基或任选取代的低级亚烷基）; Z +是任选取代的阳离子和含N原子的杂环基），酯，氨基保护的化合物 其中氨基与7-位的噻唑环或其药学上可接受的盐或溶剂化物的键合。