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公开(公告)号：US20230121387A1
公开(公告)日：2023-04-20
申请号：US17908075
申请日：2021-03-05
摘要： Provided are methods of treating muscle atrophy by administering a NELL1 polypeptide, or a nucleic acid molecule encoding a NELL1 polypeptide, to a subject in need thereof. Such subjects include pediatric subjects, cancer patients, patients with relatively high circulating levels of interleukin-1 beta (IL-1β), and patients suffering from chronic systemic inflammation, particularly inflammation associated with interleukin-1 beta (IL-1β).
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公开(公告)号：US11667684B2
公开(公告)日：2023-06-06
申请号：US17749779
申请日：2022-05-20
发明人： Cymbeline T. Culiat
CPC分类号： C07K14/4705 , A61K38/1709 , C07K14/47
摘要： Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
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公开(公告)号：US20220281932A1
公开(公告)日：2022-09-08
申请号：US17749779
申请日：2022-05-20
发明人： CYMBELINE T. CULIAT
摘要： Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
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公开(公告)号：US20180057550A1
公开(公告)日：2018-03-01
申请号：US15690093
申请日：2017-08-29
发明人： CYMBELINE T. CULIAT
摘要： Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
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公开(公告)号：US11891424B2
公开(公告)日：2024-02-06
申请号：US17333406
申请日：2021-05-28
发明人： Cymbeline T. Culiat
CPC分类号： C07K14/4705 , A61K38/1709 , C07K14/47
摘要： Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
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公开(公告)号：US20230116082A1
公开(公告)日：2023-04-13
申请号：US17908080
申请日：2021-03-05
摘要： Provided are methods of treating virally-induced tissue damage (e.g., lung tissue damage, heart tissue and/or vasculature damage, skeletal muscle damage) and/or inflammation by administering a NELL1 polypeptide, or a nucleic acid molecule encoding a NELL1 polypeptide, to a subject in need thereof. Methods of regenerating lung tissue in a subject are also provided wherein a NELL1 polypeptide or a nucleic acid molecule encoding the same is administered to a subject with damaged lung tissue
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公开(公告)号：US11034741B2
公开(公告)日：2021-06-15
申请号：US16813376
申请日：2020-03-09
发明人： Cymbeline T. Culiat
摘要： Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
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公开(公告)号：US20240301020A1
公开(公告)日：2024-09-12
申请号：US18391146
申请日：2023-12-20
发明人： CYMBELINE T. CULIAT
CPC分类号： C07K14/4705 , A61K38/1709 , C07K14/47
摘要： Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
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公开(公告)号：US20210355179A1
公开(公告)日：2021-11-18
申请号：US17333406
申请日：2021-05-28
发明人： CYMBELINE T. CULIAT
摘要： Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
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公开(公告)号：US10752663B2
公开(公告)日：2020-08-25
申请号：US15690093
申请日：2017-08-29
发明人： Cymbeline T. Culiat
摘要： Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
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