公开(公告)号：US09663521B2

公开(公告)日：2017-05-30

申请号：US14364759

申请日：2012-12-17

Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  UNIVERSITY OF KANSAS ,  NORTH-WESTERN UNIVERSITY

Inventor： Kevin Frankowski ,  Samarjit Patnaik ,  Sui Huang ,  Juan Jose Marugan ,  John Norton ,  Frank J. Schoenen ,  Noel Terrence Southall ,  Steven Titus ,  Wei Zheng

IPC: C07D487/04 ,  A61K31/519 ,  A61K31/695 ,  A61K45/06 ,  C07F7/18 ,  A61P35/02 ,  A61P35/04

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/695 ,  A61K45/06 ,  C07F7/1804

Abstract: The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.