公开(公告)号：US07083778B2

公开(公告)日：2006-08-01

申请号：US10385473

申请日：2003-03-12

申请人： Michel Schneider ,  Feng Yan ,  Nadine Garcel, legal representative ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Pascal Grenier, deceased

IPC分类号： A18B8/00

CPC分类号： A61K49/223

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.