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1.发明申请公开(公告)号：US20130137710A1
公开(公告)日：2013-05-30
申请号：US13699487
申请日：2010-05-25
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
摘要翻译： 本发明涉及以下给出的某些式（I）环己基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为抗脂肪团活性物质。 本发明还涉及包含这样的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品，其优选适用于预防（预防）和化妆品处理（抗击）人体中的脂肪团，相应的方法和新的化合物 式（I）其中A表示其中X，Y和Z彼此独立地表示氢，C 1 -C 4 - 烷基或C 2 -C 4 - 烯基，其中任选地，基团X，Y和Z中的两个彼此共价键合 双环体系的形成在这样的双环体系中，基团X，Y和Z中的两个一起优选形成具有1至4个碳原子的基团，优选地具有1至3个碳原子的烃基，B表示NR1R2，其中 R1表示氢或具有1至14个碳原子的有机基团，R2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选使得 B是3至8元环。
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公开(公告)号：US20110034486A1
公开(公告)日：2011-02-10
申请号：US12849600
申请日：2010-08-03
申请人： Imke Meyer , Oskar Koch , Nadine Hillebrand , Martina Herrmann , Holger Joppe
发明人： Imke Meyer , Oskar Koch , Nadine Hillebrand , Martina Herrmann , Holger Joppe
IPC分类号： A61K31/522 , C07D493/04 , A61K31/352 , A61K8/49 , A61P17/00 , A61Q19/06
摘要： The invention relates to a cosmetic, dermatological or pharmaceutical preparation, containing one, two or more compounds of formula (I) and/or a pharmaceutically acceptable salt of a compound of this type, (i) for use in a method for preventing, treating or reducing cellulite, and/or (ii) in an adequate quantity to reduce the lipid quantity contained in subcutaneous fat tissue, and/or to inhibit the differentiation of preadipocytes, and/or to inhibit the lipogenesis in adipocytes, wherein the radicals R1 to R8, independently of one another, signify hydrogen, hydroxy or C1-C4-alkoxy, and/or two adjacent radicals together form a methylenedioxy group.
摘要翻译： 本发明涉及含有一种，两种或更多种式（I）化合物和/或这种化合物的药学上可接受的盐的化妆品，皮肤病学或药物制剂，（i）用于预防，治疗的方法 或（ii）足够的量以减少皮下脂肪组织中含有的脂质量和/或抑制前脂肪细胞的分化和/或抑制脂肪细胞中的脂肪生成，其中R1至 R8彼此独立地表示氢，羟基或C1-C4-烷氧基，和/或两个相邻的基团一起形成亚甲二氧基。
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公开(公告)号：US08633203B2
公开(公告)日：2014-01-21
申请号：US12849600
申请日：2010-08-03
申请人： Imke Meyer , Oskar Koch , Nadine Hillebrand , Martina Herrmann , Holger Joppe
发明人： Imke Meyer , Oskar Koch , Nadine Hillebrand , Martina Herrmann , Holger Joppe
IPC分类号： A61K31/522 , A61K31/35 , C07D311/78 , C07D311/94
摘要： The invention relates to a cosmetic, dermatological or pharmaceutical preparation, containing one, two or more compounds of formula (I) and/or a pharmaceutically acceptable salt of a compound of this type, (i) for use in a method for preventing, treating or reducing cellulite, and/or (ii) in an adequate quantity to reduce the lipid quantity contained in subcutaneous fat tissue, and/or to inhibit the differentiation of preadipocytes, and/or to inhibit the lipogenesis in adipocytes, wherein the radicals R1 to R8, independently of one another, signify hydrogen, hydroxy or C1-C4-alkoxy, and/or two adjacent radicals together form a methylenedioxy group.
摘要翻译： 本发明涉及含有一种，两种或更多种式（I）化合物和/或这种化合物的药学上可接受的盐的化妆品，皮肤病学或药物制剂，（i）用于预防，治疗的方法 或（ii）足够的量以减少皮下脂肪组织中含有的脂质量和/或抑制前脂肪细胞的分化和/或抑制脂肪细胞中的脂肪生成，其中R1至 R8彼此独立地表示氢，羟基或C1-C4-烷氧基，和/或两个相邻的基团一起形成亚甲二氧基。
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公开(公告)号：US09012497B2
公开(公告)日：2015-04-21
申请号：US13699487
申请日：2010-05-25
摘要： The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
摘要翻译： 本发明涉及以下给出的某些式（I）环己基氨基甲酸酯化合物的化妆品，皮肤病学或治疗用途，优选作为抗脂肪团活性物质。 本发明还涉及包含这样的式（I）化合物的组合物和化妆品，皮肤病学或治疗产品，其优选适用于预防（预防）和化妆品处理（抗击）人体中的脂肪团，相应的方法和新的化合物 式（I）其中A表示其中X，Y和Z彼此独立地表示氢，C 1 -C 4 - 烷基或C 2 -C 4 - 烯基，其中任选地，基团X，Y和Z中的两个彼此共价键合 双环体系的形成在这样的双环体系中，基团X，Y和Z中的两个一起优选形成具有1至4个碳原子的基团，优选地具有1至3个碳原子的烃基，B表示NR1R2，其中 R1表示氢或具有1至14个碳原子的有机基团，R2表示具有1至14个碳原子的有机基团，并且其中任选地R 1和R 2彼此共价键合，优选使得 B是3至8元环。
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