公开(公告)号：US20090286981A1

公开(公告)日：2009-11-19

申请号：US12352182

申请日：2009-01-12

申请人： Uma Maheswer Rao Vasireddy ,  Siva Rama Prasad Vellanki ,  Raja Babu Balusu ,  Naga Durga Rao Bandi ,  Pavan Kumar Jujjavarapu ,  Sambasiva Rao Ginjupalli ,  Rama Krishna Pilli

发明人： Uma Maheswer Rao Vasireddy ,  Siva Rama Prasad Vellanki ,  Raja Babu Balusu ,  Naga Durga Rao Bandi ,  Pavan Kumar Jujjavarapu ,  Sambasiva Rao Ginjupalli ,  Rama Krishna Pilli

IPC分类号： C07F9/6561

CPC分类号： C07D473/34 ,  C07F9/65616

摘要： The present invention relates to novel Tenofovir disoproxil hemifumarate salt, which is prepared by dealkylation of Phosphonate esters by using mineral acids followed by esterification and crystallization to give crystalline Tenofovir disoproxil. The Tenofovir disoproxil is further converted to fumarate salts with improved yield.

摘要翻译： 本发明涉及通过使用无机酸通过膦酸酯脱烷基化，然后进行酯化和结晶以得到结晶替诺福韦酯的方法制备的替诺福韦替比夫昔半富马酸盐。 替诺福韦酯是进一步转化为富马酸盐，产率提高。

公开(公告)号：US08049009B2

公开(公告)日：2011-11-01

申请号：US12352182

申请日：2009-01-12

申请人： Uma Maheswer Rao Vasireddy ,  Siva Rama Prasad Vellanki ,  Raja Babu Balusu ,  Naga Durga Rao Bandi ,  Pavan Kumar Jujjavarapu ,  Sambasiva Rao Ginjupalli ,  Rama Krishna Pilli

发明人： Uma Maheswer Rao Vasireddy ,  Siva Rama Prasad Vellanki ,  Raja Babu Balusu ,  Naga Durga Rao Bandi ,  Pavan Kumar Jujjavarapu ,  Sambasiva Rao Ginjupalli ,  Rama Krishna Pilli

IPC分类号： C07F9/6561

CPC分类号： C07D473/34 ,  C07F9/65616

摘要： The present invention relates to novel Tenofovir disoproxil hemifumarate salt, which is prepared by dealkylation of Phosphonate esters by using mineral acids followed by esterification and crystallization to give crystalline Tenofovir disoproxil. The Tenofovir disoproxil is further converted to fumarate salts with improved yield.

摘要翻译： 本发明涉及通过使用无机酸通过膦酸酯脱烷基化，然后进行酯化和结晶以得到结晶替诺福韦酯的方法制备的替诺福韦替比夫昔半富马酸盐。 替诺福韦酯是进一步转化为富马酸盐，产率提高。