公开(公告)号：US06379664B1

公开(公告)日：2002-04-30

申请号：US09162564

申请日：1998-09-29

申请人： Marjorie F. Lou ,  Nalini Raghavachari ,  Fengyu Qiao

发明人： Marjorie F. Lou ,  Nalini Raghavachari ,  Fengyu Qiao

IPC分类号： A61K3845

CPC分类号： C12N9/13 ,  A61K38/45

摘要： Thioltransferase and derivatives thereof are provided. Methods of treating or preventing cataract formation comprising administering thioltransferase or a derivative thereof are also provided. Thioltransferase or derivatives thereof are also useful for treating or preventing diseases resulting from or associated with oxidative stress. Human lens thioltransferase and a DNA sequence encoding the same are also provided.

摘要翻译： 提供硫醇转移酶及其衍生物。 还提供了治疗或预防白内障形成的方法，包括给予硫羟转移酶或其衍生物。 硫醇转移酶或其衍生物也可用于治疗或预防由氧化应激引起或与氧化应激相关的疾病。 还提供人晶状体硫醇转移酶和编码其的DNA序列。

公开(公告)号：US20100297215A1

公开(公告)日：2010-11-25

申请号：US12463789

申请日：2009-05-11

申请人： William E. Fahl ,  Nalini Raghavachari ,  Ming Zhu ,  John A. Kink

发明人： William E. Fahl ,  Nalini Raghavachari ,  Ming Zhu ,  John A. Kink

IPC分类号： A61K9/127 ,  A61P35/00 ,  C12Q1/68 ,  A61K31/428 ,  A61K31/352 ,  A61K31/275 ,  A61K31/497 ,  A61K31/05 ,  A61K31/085

CPC分类号： A61K31/497 ,  A61K9/127 ,  A61K9/1272 ,  A61K35/36

摘要： Compositions, pharmaceutical preparations and methods are disclosed for protecting non-neoplastic cells from damage caused by cancer chemotherapeutic agents or radiation therapy, during the course of cancer therapy or bone marrow transplant. These are based on the use of chemoprotective inducing agents that induce or increase production of cellular detoxification enzymes in target cell populations. The compositions and methods are useful to reduce or prevent hair loss, gastrointestinal distress and lesions of the skin and oral mucosa that commonly occur in patients undergoing cancer therapy. Also disclosed is a novel assay system for identifying new chemoprotective inducing agents.

摘要翻译： 公开了用于在癌症治疗或骨髓移植过程中保护非肿瘤细胞免受由癌症化学治疗剂或放射治疗引起的损伤的组合物，药物制剂和方法。 这些是基于在靶细胞群体中诱导或增加细胞解毒酶的产生的化学保护诱导剂的用途。 组合物和方法可用于减少或预防通常在经历癌症治疗的患者中发生的脱发，胃肠道窘迫和皮肤和口腔粘膜的损伤。 还公开了用于鉴定新的化学保护诱导剂的新型测定系统。

公开(公告)号：US07364849B2

公开(公告)日：2008-04-29

申请号：US10729619

申请日：2003-12-05

申请人： Yijia Bao ,  Guangshan Li ,  Nalini Raghavachari ,  Mingqian He ,  Xinying Xie ,  Yuming Xie

发明人： Yijia Bao ,  Guangshan Li ,  Nalini Raghavachari ,  Mingqian He ,  Xinying Xie ,  Yuming Xie

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： G01N33/54393

摘要： A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.

摘要翻译： 公开了一种处理基板以固定生物分子的方法和通过该方法制备的基板。 该方法包括使至少一部分底物与还原剂如氢化物接触。 用合适的还原剂进行处理基本上消除了底物上的自发荧光。

公开(公告)号：US08461136B2

公开(公告)日：2013-06-11

申请号：US12463789

申请日：2009-05-11

申请人： William E. Fahl ,  Nalini Raghavachari ,  Ming Zhu ,  John A. Kink

发明人： William E. Fahl ,  Nalini Raghavachari ,  Ming Zhu ,  John A. Kink

IPC分类号： A01N57/00 ,  A61K31/67

CPC分类号： A61K31/497 ,  A61K9/127 ,  A61K9/1272 ,  A61K35/36

摘要： Compositions, pharmaceutical preparations and methods are disclosed for protecting non-neoplastic cells from damage caused by cancer chemotherapeutic agents or radiation therapy, during the course of cancer therapy or bone marrow transplant. These are based on the use of chemoprotective inducing agents that induce or increase production of cellular detoxification enzymes in target cell populations. The compositions and methods are useful to reduce or prevent hair loss, gastrointestinal distress and lesions of the skin and oral mucosa that commonly occur in patients undergoing cancer therapy. Also disclosed is a novel assay system for identifying new chemoprotective inducing agents.

公开(公告)号：US07531562B2

公开(公告)日：2009-05-12

申请号：US10881028

申请日：2004-06-30

申请人： William E. Fahl ,  Nalini Raghavachari ,  Ming Zhu ,  John A. Kink

发明人： William E. Fahl ,  Nalini Raghavachari ,  Ming Zhu ,  John A. Kink

IPC分类号： A61K31/425

CPC分类号： A61K31/497 ,  A61K9/127 ,  A61K9/1272 ,  A61K35/36

摘要： Compositions, pharmaceutical preparations and methods are disclosed for protecting non-neoplastic cells from damage caused by cancer chemotherapeutic agents or radiation therapy, during the course of cancer therapy or bone marrow transplant. These are based on the use of chemoprotective inducing agents that induce or increase production of cellular detoxification enzymes in target cell populations. The compositions and methods are useful to reduce or prevent hair loss, gastrointestinal distress and lesions of the skin and oral mucosa that commonly occur in patients undergoing cancer therapy. Also disclosed is a novel assay system for identifying new chemoprotective inducing agents.

摘要翻译： 公开了用于在癌症治疗或骨髓移植过程中保护非肿瘤细胞免受由癌症化学治疗剂或放射治疗引起的损伤的组合物，药物制剂和方法。 这些是基于在靶细胞群体中诱导或增加细胞解毒酶的产生的化学保护诱导剂的用途。 组合物和方法可用于减少或预防通常在经历癌症治疗的患者中发生的脱发，胃肠道窘迫和皮肤和口腔粘膜损伤。 还公开了用于鉴定新的化学保护诱导剂的新型测定系统。

公开(公告)号：US07141374B2

公开(公告)日：2006-11-28

申请号：US10729618

申请日：2003-12-05

申请人： Yijia Bao ,  Guangshan Li ,  Nalini Raghavachari ,  Mingqian He ,  Xinying Xie ,  Yuming Xie

发明人： Yijia Bao ,  Guangshan Li ,  Nalini Raghavachari ,  Mingqian He ,  Xinying Xie ,  Yuming Xie

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/54393

摘要： A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.

公开(公告)号：US06787312B2

公开(公告)日：2004-09-07

申请号：US09925808

申请日：2001-08-09

申请人： Yijia Bao ,  Guangshan Li ,  Nalini Raghavachari ,  Mingqian He ,  Xinying Xie ,  Yuming Xie

发明人： Yijia Bao ,  Guangshan Li ,  Nalini Raghavachari ,  Mingqian He ,  Xinying Xie ,  Yuming Xie

IPC分类号： C12Q168

CPC分类号： G01N33/54393

摘要： A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.

摘要翻译： 公开了一种处理基板以固定生物分子的方法和通过该方法制备的基板。 该方法包括使至少一部分底物与还原剂如氢化物接触。 用合适的还原剂进行处理基本上消除了底物上的自发荧光。

公开(公告)号：US20050043224A1

公开(公告)日：2005-02-24

申请号：US10881028

申请日：2004-06-30

申请人： William Fahl ,  Nalini Raghavachari ,  Ming Zhu ,  John Kink

发明人： William Fahl ,  Nalini Raghavachari ,  Ming Zhu ,  John Kink

IPC分类号： G01N33/483 ,  A61K9/08 ,  A61K9/107 ,  A61K9/127 ,  A61K9/66 ,  A61K31/015 ,  A61K31/05 ,  A61K31/085 ,  A61K31/21 ,  A61K31/352 ,  A61K31/428 ,  A61K31/497 ,  A61K45/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/34 ,  A61P35/00 ,  A61P39/00 ,  G01N21/77 ,  G01N21/78 ,  G01N33/15 ,  G01N33/50 ,  A61K38/17 ,  A61K31/7076 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7072 ,  A61K31/4745

CPC分类号： A61K31/497 ,  A61K9/127 ,  A61K9/1272 ,  A61K35/36

摘要： Compositions, pharmaceutical preparations and methods are disclosed for protecting non-neoplastic cells from damage caused by cancer chemotherapeutic agents or radiation therapy, during the course of cancer therapy or bone marrow transplant. These are based on the use of chemoprotective inducing agents that induce or increase production of cellular detoxification enzymes in target cell populations. The compositions and methods are useful to reduce or prevent hair loss, gastrointestinal distress and lesions of the skin and oral mucosa that commonly occur in patients undergoing cancer therapy. Also disclosed is a novel assay system for identifying new chemoprotective inducing agents.

摘要翻译： 公开了用于在癌症治疗或骨髓移植过程中保护非肿瘤细胞免受由癌症化学治疗剂或放射治疗引起的损伤的组合物，药物制剂和方法。 这些是基于在靶细胞群体中诱导或增加细胞解毒酶的产生的化学保护诱导剂的用途。 组合物和方法可用于减少或预防通常在经历癌症治疗的患者中发生的脱发，胃肠道窘迫和皮肤和口腔粘膜的损伤。 还公开了用于鉴定新的化学保护诱导剂的新型测定系统。