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公开(公告)号：US20240358766A1
公开(公告)日：2024-10-31
申请号：US18565007
申请日：2022-05-27
Applicant: Stratatech Corporation
Inventor： Allen R. Comer , Kenneth R. Gratz
CPC classification number: A61K35/36 , A61F2/105 , A61L27/24 , A61L27/3813 , A61L27/60 , A61P17/02 , A61L2430/34
Abstract: The present disclosure is directed to allogeneic cultured keratinocyte products.
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2.发明授权公开(公告)号：US12090176B2
公开(公告)日：2024-09-17
申请号：US17604040
申请日：2019-04-17
Applicant: NEXUS BIO-DRUG DEVELOPMENT LIMITED
Inventor： Shing Hing Lau
Abstract: Disclosed is therapeutic use of an extract from rabbit skin inflamed by vaccinia virus. Particularly, disclosed is use of an extract from rabbit skin inflamed by vaccinia virus in treating hematopoietic system damage or pancytopenia induced by an anti-cancer therapy. Moreover, disclosed is use of an extract from rabbit skin inflamed by vaccinia virus in treating leukopenia induced by an anti-cancer therapy. Further, the extract from rabbit skin inflamed by vaccinia virus can be Lepalvir.
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公开(公告)号：US20240245729A1
公开(公告)日：2024-07-25
申请号：US18565003
申请日：2022-05-27
Applicant: Stratatech Corporation
Inventor： Allen R. Comer , Kenneth R. Gratz
CPC classification number: A61K35/36 , A61K9/0014 , A61K35/33 , A61K38/39 , C12N5/0698 , C12N2500/12 , C12N2500/20 , C12N2500/32 , C12N2500/34 , C12N2500/38 , C12N2533/54
Abstract: The present disclosure encompasses methods for priming an allogeneic cultured keratinocyte composition for topical use.
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公开(公告)号：US12011464B2
公开(公告)日：2024-06-18
申请号：US17276230
申请日：2019-09-19
Applicant: STEMON INC.
Inventor： Yong Seung Lee
CPC classification number: A61K35/36 , A61P17/14 , C12N5/0625 , C12N13/00 , C12N2529/00
Abstract: A method for producing exosomes comprises steps of: providing ultrasound stimulation directly or indirectly to cells; culturing a mixture of the cells and a medium for a predetermined time; and isolating exosomes from the mixture, wherein providing the stimulation directly to the cells comprises applying ultrasound stimulation to the medium containing the cells, and the providing the stimulation indirectly to the cells comprises applying ultrasound stimulation to the medium not containing the cells and then mixing the medium and the cells. This method for producing exosomes makes it possible to obtain exosomes having a hair regeneration effect not only from stem cells and progenitor cells that are difficult to isolate and multiply, but also from somatic cells that may be easily obtained and maintained, in high yield within a short time by ultrasound treatment that is a simple process.
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公开(公告)号：US20240066070A1
公开(公告)日：2024-02-29
申请号：US18272044
申请日：2022-01-11
Applicant: AgeX Therapeutics, Inc.
Inventor： Michael D. West
CPC classification number: A61K35/42 , A61K35/36 , A61L27/38 , A61L27/52 , C12N5/0625 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2510/00
Abstract: Methods are provided for the ex vivo reprogramming of microbiopsies of tissue such as from the skin, wherein the cells from the tissue are reverted to a state capable of extensive expansion in volume and when transplanted in vivo, of promoting scarless tissue regeneration at the site of administration.
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Patent Agency Ranking
公开(公告)号：US20240041939A1
公开(公告)日：2024-02-08
申请号：US18067204
申请日：2022-12-16
Applicant: William Marsh Rice University
Inventor： Omid VEISEH , Amanda NASH , Samira AGHLARA-FOTOVAT
CPC classification number: A61K35/36 , C12N5/0602 , C07K14/5434 , C12N11/08 , A61P35/00
Abstract: The present disclosure relates to implantable constructs (encapsulated cells) designed to deliver therapeutic reagents, such as IL-12 and/or IL-12 and methods of using the same to treat conditions, such as cancer.
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公开(公告)号：US11891593B2
公开(公告)日：2024-02-06
申请号：US17897560
申请日：2022-08-29
Applicant: The General Hospital Corporation
Inventor： Harald C. Ott
IPC: A01N1/00 , C12M3/00 , A01N1/02 , C12M1/00 , C12M1/36 , A61K35/42 , A61K35/36 , A61K35/44 , A61K35/28 , C12M1/12 , C12M1/34
CPC classification number: C12M21/08 , A01N1/0247 , A61K35/28 , A61K35/36 , A61K35/42 , A61K35/44 , C12M25/14 , C12M29/10 , C12M41/40 , C12M41/44 , C12M41/48
Abstract: Presented is an airway organ bioreactor apparatus, and methods of use thereof, as well as bioartificial airway organs produced using the methods, and methods of treating subjects using the bioartificial airway organs. The bioreactor comprises: an organ chamber: an ingres line connecting the organ chamber and a reservoir system and comprising an arterial line, a venous line and a tracheal line; an egress line connecting the chamber and the reservoir system, pumps in ingress and egress lines; a controller to control fluid exchange; a chamber pressure sensor connected to the organ chamber.
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公开(公告)号：US11787850B2
公开(公告)日：2023-10-17
申请号：US17138448
申请日：2020-12-30
Applicant: Anie Philip
Inventor： Anie Philip
IPC: A61K38/10 , A61K38/16 , A61K38/18 , C07K14/495 , A61K38/00 , C07K7/00 , C07K14/705 , A61L17/00 , A61L24/00 , A61K35/36 , C12N15/86 , C12N15/87 , C07K14/71 , A61L31/16 , A01K67/027 , A61L15/44 , A61K38/03 , C07K7/08 , C07K14/00 , A61P1/16 , A61P17/02 , A61P35/00 , A61K9/00 , A61K9/70
CPC classification number: C07K14/70596 , A01K67/0271 , A61K9/006 , A61K9/0019 , A61K9/0048 , A61K9/0073 , A61K9/7038 , A61K35/36 , A61K38/00 , A61K38/03 , A61K38/10 , A61K38/16 , A61K38/1841 , A61L15/44 , A61L17/005 , A61L24/0015 , A61L31/16 , A61P1/16 , A61P17/02 , A61P35/00 , C07K7/00 , C07K7/08 , C07K14/00 , C07K14/495 , C07K14/71 , C12N15/86 , C12N15/87 , A61L2300/432 , Y02A50/30
Abstract: The present invention provides peptidic TGF-β antagonists capable of inhibiting TGF-β signaling and disrupting the biochemical events that promote fibrosis and the epithelial-mesenchymal transition. The peptidic TGF-β antagonist may contain from 11 to 28 amino acid residues (for instance, may consist of from 12 to 16 amino acid residues) and may have the following structure (II):
NH2′ETWIWLDTNMG-Xaa1-Y′COOH (II)
wherein Xaa1 is any amino acid and Y is a peptide having from 0 to 9 amino acids. The peptidic TGF-β antagonists can advantageously be used for the prevention, treatment, and/or alleviation of the symptoms of a condition associated with an increase in TGF-β activity, including fibrosis (such as fibrosis of the skin, liver, lungs, and heart, among others) and cancer (including various carcinomas, such as squamous cell carcinoma, sarcomas, and metastatic cancers).-
公开(公告)号：US20230313136A1
公开(公告)日：2023-10-05
申请号：US18120301
申请日：2023-03-10
Applicant: Children's Medical Center Corporation
Inventor： Markus H. Frank
IPC: C12N5/071 , A61K35/36 , C12N5/0775 , A61P19/04 , A61P19/08
CPC classification number: C12N5/0625 , A61K35/36 , C12N5/0668 , A61P19/04 , A61P19/08
Abstract: The present invention is directed to purified preparations of dermal mesenchymal stem cells that are characterized by the cell surface expression of the ABCB5 P-glycoprotein. The cells may be used for any purpose that mesenchymal stem cells from other course are used. For instance they may be administered to treat an organ transplant recipient to improve allograft survival or as a treatment to patients with autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
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公开(公告)号：US20230287344A1
公开(公告)日：2023-09-14
申请号：US18140279
申请日：2023-04-27
Inventor： Karl Tryggvason , Monica Suryana Tjin , Alvin Wen Choong Chua
CPC classification number: C12N5/0629 , A61K35/36 , C12N5/0068 , C12N5/0698 , C12N2500/02 , C12N2500/90 , C12N2500/98 , C12N2533/52
Abstract: The present disclosure relates to methods for culturing human epidermal keratinocytes. When keratinocytes are cultured on plates coated with a laminin containing an alpha-4 chain or an alpha-5 chain, in a xeno-free, chemically defined cell culture medium, they expand efficiently in vitro. Useful cell culture kits for culturing keratinocytes are also described herein, as are methods of using such cells for treatment of burns or chronic wounds.
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