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公开(公告)号:US20070048305A1
公开(公告)日:2007-03-01
申请号:US11366003
申请日:2006-02-28
申请人: C. Davis , Russell Blacher , Jose Corvalan , Alan Culwell , Larry Green , Joanna Hales , Nancy Havrilla , Vladimir Ivanov , John Lipani , Qiang Liu , Richard Weber , Xiao-Dong Yang
发明人: C. Davis , Russell Blacher , Jose Corvalan , Alan Culwell , Larry Green , Joanna Hales , Nancy Havrilla , Vladimir Ivanov , John Lipani , Qiang Liu , Richard Weber , Xiao-Dong Yang
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K16/2803 , A61K2039/505 , C07K14/70596 , C07K16/2896 , C07K2317/21 , C07K2317/34 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要: In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.
摘要翻译: 根据本发明,我们发现在诸如T细胞,B细胞和/或单核细胞的某些细胞上表达的分子CD147可用于治疗各种疾病。 特别地,我们已经证明,结合CD147并导致这种细胞的杀伤,例如通过补体结合的抗体在治疗疾病中是有效的。 这种治疗显示有效的疾病包括但不限于:移植物抗宿主病(GVHD),器官移植排斥疾病(包括但不限于肾移植,眼部移植等),癌症(包括但不限于: 血液(即白血病和淋巴瘤),胰腺等),自身免疫疾病,炎性疾病等。
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公开(公告)号:US20060104974A1
公开(公告)日:2006-05-18
申请号:US09784950
申请日:2001-02-15
申请人: C. Davis , Russell Blacher , Jose Corvalan , Alan Culwell , Larry Green , Joanne Hales , Nancy Havrilla , Vladimir Ivanov , John Lipani , Qiang Liu , Richard Weber , Xiao-Dong Yang
发明人: C. Davis , Russell Blacher , Jose Corvalan , Alan Culwell , Larry Green , Joanne Hales , Nancy Havrilla , Vladimir Ivanov , John Lipani , Qiang Liu , Richard Weber , Xiao-Dong Yang
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K16/2803 , A61K2039/505 , C07K14/70596 , C07K16/2896 , C07K2317/21 , C07K2317/34 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要: In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.
摘要翻译: 根据本发明,我们发现在诸如T细胞,B细胞和/或单核细胞的某些细胞上表达的分子CD147可用于治疗各种疾病。 特别地,我们已经证明,结合CD147并导致这种细胞的杀伤,例如通过补体结合的抗体在治疗疾病中是有效的。 这种治疗显示有效的疾病包括但不限于:移植物抗宿主病(GVHD),器官移植排斥疾病(包括但不限于肾移植,眼部移植等),癌症(包括但不限于: 血液(即白血病和淋巴瘤),胰腺等),自身免疫疾病,炎性疾病等。
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