公开(公告)号：US5021584A

公开(公告)日：1991-06-04

申请号：US403460

申请日：1989-09-06

申请人： Natsuo Sawa ,  Takeshi Masuda ,  Shozo Miura ,  Naoki Kano ,  Kazuo Kamagata ,  Masayuki Ito

发明人： Natsuo Sawa ,  Takeshi Masuda ,  Shozo Miura ,  Naoki Kano ,  Kazuo Kamagata ,  Masayuki Ito

IPC分类号： C07D233/54 ,  C07D233/58 ,  C07D521/00

CPC分类号： C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Disclosed is a process for the preparation of a 1-benzylimidazole compound represented by the following general formula: ##STR1## wherein R.sub.2 represents a lower alkyl group or phenyl group, and R.sub.4 represents a hydrogen atom or a methyl group,which comprises heating and to react a 1-unsubstituted imidazole compound represented by the following general formula: ##STR2## wherein R.sub.2 and R.sub.4 are as defined above, with benzyl alcohol in the presence of a carboxylic acid, a carboxylic anhydride, a benzyl ester thereof or a lower alkyl ester thereof, and neutralizing the reaction product with an alkali.

公开(公告)号：US4432959A

公开(公告)日：1984-02-21

申请号：US404867

申请日：1982-08-03

申请人： Tadao Shimamura ,  Naoki Kano

发明人： Tadao Shimamura ,  Naoki Kano

IPC分类号： C07D251/32 ,  C01C3/00

CPC分类号： C07D251/32

摘要： A process for producing sodium cyanurate in the powdery form is disclosed. In this method, iso cyanuric acid is reacted with sodium carbonate or sodium hydrogencarbonate or a mixture of sodium carbonate and sodium hydrogencarbonate by mixing the raw materials in powdery form and in the presence of water in a range, in which hydrates can be formed from the raw materials at room temperature, while holding the system at a temperature at which free water can be produced.

摘要翻译： 公开了一种生产粉末状氰尿酸钠的方法。 在该方法中，将异氰脲酸与碳酸钠或碳酸氢钠或碳酸钠和碳酸氢钠的混合物与粉末状的原料和水的存在下，在一定范围内混合，其中水合物可由 原料在室温下，同时将系统保持在可以产生游离水的温度。

公开(公告)号：US5514811A

公开(公告)日：1996-05-07

申请号：US195474

申请日：1994-02-14

申请人： Takayuki Murai ,  Tokuichi Saeki ,  Suzuko Satou ,  Shozo Miura ,  Tomoko Takashige ,  Naoki Kano

发明人： Takayuki Murai ,  Tokuichi Saeki ,  Suzuko Satou ,  Shozo Miura ,  Tomoko Takashige ,  Naoki Kano

IPC分类号： C07D233/68

CPC分类号： C07D233/68

摘要： A process for preparing, on an industrial scale, 4-halo-5-(hydroxymethyl) imidazole compounds that are useful as intermediates for medicines. A 4-chloro-5-(hydroxymethyl) imidazole compound, a 4-bromo-5-(hydroxymethyl) imidazole compound or a like compound is synthesized by reacting a 4,5-bis(hydroxymethyl) imidazole compound with a halogenating agent such as an N-chlorosuccinimide, an N-bromosuccinimide, a chlorinated isocyanuric acid compound or the like compound.

摘要翻译： 以工业规模制备可用作药物中间体的4-卤代-5-（羟甲基）咪唑化合物的方法。 4-氯-5-（羟甲基）咪唑化合物，4-溴-5-（羟甲基）咪唑化合物等通过使4,5-双（羟甲基）咪唑化合物与卤化剂如 N-氯代琥珀酰亚胺，N-溴代琥珀酰亚胺，氯化异氰脲酸化合物等。