公开(公告)号：US5514811A

公开(公告)日：1996-05-07

申请号：US195474

申请日：1994-02-14

申请人： Takayuki Murai ,  Tokuichi Saeki ,  Suzuko Satou ,  Shozo Miura ,  Tomoko Takashige ,  Naoki Kano

发明人： Takayuki Murai ,  Tokuichi Saeki ,  Suzuko Satou ,  Shozo Miura ,  Tomoko Takashige ,  Naoki Kano

IPC分类号： C07D233/68

CPC分类号： C07D233/68

摘要： A process for preparing, on an industrial scale, 4-halo-5-(hydroxymethyl) imidazole compounds that are useful as intermediates for medicines. A 4-chloro-5-(hydroxymethyl) imidazole compound, a 4-bromo-5-(hydroxymethyl) imidazole compound or a like compound is synthesized by reacting a 4,5-bis(hydroxymethyl) imidazole compound with a halogenating agent such as an N-chlorosuccinimide, an N-bromosuccinimide, a chlorinated isocyanuric acid compound or the like compound.

摘要翻译： 以工业规模制备可用作药物中间体的4-卤代-5-（羟甲基）咪唑化合物的方法。 4-氯-5-（羟甲基）咪唑化合物，4-溴-5-（羟甲基）咪唑化合物等通过使4,5-双（羟甲基）咪唑化合物与卤化剂如 N-氯代琥珀酰亚胺，N-溴代琥珀酰亚胺，氯化异氰脲酸化合物等。