公开(公告)号：US20220022946A1

公开(公告)日：2022-01-27

申请号：US17492654

申请日：2021-10-03

申请人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Mohammad Ali Khayamian ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi ,  Reyhaneh Mahdavi ,  Narges Yousefpour ,  Hossein Ataee ,  Sajad Mehrvarz

发明人： Mohammad Abdolahad ,  Zohreh Sadat Miripour ,  Mohammad Ali Khayamian ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi ,  Reyhaneh Mahdavi ,  Narges Yousefpour ,  Hossein Ataee ,  Sajad Mehrvarz

IPC分类号： A61B18/14 ,  A61B18/12

摘要： A system for destroying a cancerous tumor. The system includes an electrical probe, an impedance analyzer device configured to be connected to the electrical probe, a DC voltage generator configured to be connected to the electrical probe, and a processing unit connected to the impedance analyzer device and the DC voltage generator. The electrical probe includes a first electrode including a first electrically conductive needle, a second electrode including a second electrically conductive needle with a nanoporous surface placed inside the first electrode, a first electrically insulating layer placed around the first electrode except a first distal end portion of the first electrode, and a second electrically insulating layer placed between the first electrode and the second electrode. The processing unit configured to perform destroying the cancerous tumor by executing processor-readable instructions utilizing the impedance analyzer device and the DC voltage generator.

公开(公告)号：US20220015660A1

公开(公告)日：2022-01-20

申请号：US17492252

申请日：2021-10-01

申请人： Mohammad Abdolahad ,  Reihane Mahdavi ,  Sajad Mehrvarz ,  Narges Yousefpour ,  Hossein Ataee ,  Mohammad Saeed Nikshoar ,  Naser Namdar Habashi ,  Hadi Ghafari

发明人： Mohammad Abdolahad ,  Reihane Mahdavi ,  Sajad Mehrvarz ,  Narges Yousefpour ,  Hossein Ataee ,  Mohammad Saeed Nikshoar ,  Naser Namdar Habashi ,  Hadi Ghafari

IPC分类号： A61B5/053 ,  A61B5/25 ,  A61B5/00

摘要： A method for identifying cancerous status of margins of a tumor. The method includes putting at least two electrodes of a bioimpedance sensor in contact with a target region of surface of a freshly dissected tumor tissue, measuring two impedimetric criteria associated with the target region, and detecting cancerous status of the target region based on the two measured impedimetric criteria. The two measured impedimetric criteria includes an electrical impedance magnitude of the target region at a frequency of 1 kHz (Z1 kHz) and an impedance phase slope (IPS) of the target region in a frequency range of 100 kHz to 500 kHz.

公开(公告)号：US20220022947A1

公开(公告)日：2022-01-27

申请号：US17492659

申请日：2021-10-03

申请人： Mohammad Abdolahad ,  Reyhaneh Mahdavi ,  Mohammad Ali Khayamian ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi ,  Zohreh Sadat Miripour ,  Narges Yousefpour ,  Hossein Ataee ,  Sajad Mehrvarz

发明人： Mohammad Abdolahad ,  Reyhaneh Mahdavi ,  Mohammad Ali Khayamian ,  Parisa Aghaee ,  Hadi Ghafari ,  Naser Namdar Habashi ,  Fereshteh Abbasvandi ,  Zohreh Sadat Miripour ,  Narges Yousefpour ,  Hossein Ataee ,  Sajad Mehrvarz

IPC分类号： A61B18/14

摘要： A method for destroying a cancerous tumor. The method includes putting two electrodes of an electrical probe in contact with a portion of the cancerous tumor, plotting an impedance phase diagram by measuring a set of electrical impedance phase values from the portion of the cancerous tumor at end of a respective set of pre-determined time steps, destroying cancer cells of the portion of the cancerous tumor within each time step of the respective set of pre-determined time steps by electrolyzing peripheral medium surrounding the cancer cells of the portion of the cancerous tumor by applying a direct current (DC) voltage between the two electrodes, and stopping destroying of the cancer cells responsive to a complete destruction of the portion of the cancerous tumor, where the complete destruction includes obtaining a positive slope of the impedance phase diagram (IPS).

公开(公告)号：US20220022771A1

公开(公告)日：2022-01-27

申请号：US17492651

申请日：2021-10-03

申请人： Mohammad Abdolahad ,  Reihane Mahdavi ,  Sajad Mehrvarz ,  Narges Yousefpour ,  Hossein Ataee ,  Saeed Abdolhosseini ,  Naser Namdar Habashi ,  Farzaneh Hajighasemi ,  Hadi Ghafari

发明人： Mohammad Abdolahad ,  Reihane Mahdavi ,  Sajad Mehrvarz ,  Narges Yousefpour ,  Hossein Ataee ,  Saeed Abdolhosseini ,  Naser Namdar Habashi ,  Farzaneh Hajighasemi ,  Hadi Ghafari

IPC分类号： A61B5/06 ,  A61B5/00 ,  A61B5/25 ,  G01N33/574

摘要： A method for real-time and in-vivo detecting cancerous status of a suspected mass to in a living body. The method includes putting two electrodes of an electrical probe in contact with the suspected mass, recording an electrical impedance spectroscopy (EIS) from the suspected mass utilizing an impedance analyzer device connected to the electrical probe by plotting an impedance phase diagram respective to a swept range of frequencies while applying an alternating current (AC) voltage between the two electrodes, calculating an impedance phase slope (IPS) of the plotted impedance phase diagram in a frequency range between 100 kHz and 500 kHz, and detecting cancerous status of the suspected mass based on the calculated IPS. Detecting cancerous status of the suspected mass based on the calculated IPS includes detecting the suspected mass is a cancerous mass or a precancerous mass if the calculated IPS is less than a reference IPS.